Preparation and antitumor activity of new mitomycin A analogs

A series of 26 mitomycin A analogues including 23 new ones was prepared by a variety of methods. The most useful methods were alkoxide exchange on mitomycin A and treatment of 7-hydroxymitosane with 3-substituted 1-phenyltriazenes. Many of the new analogues were superior to mitomycin C in the P388 l...

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Veröffentlicht in:	Journal of medicinal chemistry 1987-01, Vol.30 (1), p.168-173
Hauptverfasser:	Sami, Salah M, Iyengar, Bhashyam S, Remers, William A, Bradner, William T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chemistry Drug Evaluation, Preclinical Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Indicators and Reagents Leukemia P388 - drug therapy Magnetic Resonance Spectroscopy Melanoma, Experimental - drug therapy Mice Mitomycins - chemical synthesis Mitomycins - therapeutic use Organic chemistry Preparations and properties Structure-Activity Relationship
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