On Low-Barrier Hydrogen Bonds and Enzyme Catalysis
The contention that low-barrier hydrogen bonds support enzyme catalysis by means of 'resonance stabilization' is disputed. It is suggested that an opposite, destabilization process occurs. Two replies are included.
Gespeichert in:
| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1995-07, Vol.269 (5220), p.102-106 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 106 |
|---|---|
| container_issue | 5220 |
| container_start_page | 102 |
| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 269 |
| creator | Warshel, Arieh Papazyan, Arno Kollman, Peter A. Cleland, W. W. Kreevoy, Maurice M. Frey, Perry A. |
| description | The contention that low-barrier hydrogen bonds support enzyme catalysis by means of 'resonance stabilization' is disputed. It is suggested that an opposite, destabilization process occurs. Two replies are included. |
| doi_str_mv | 10.1126/science.7661987 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_77381045</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A17286252</galeid><jstor_id>2889165</jstor_id><sourcerecordid>A17286252</sourcerecordid><originalsourceid>FETCH-LOGICAL-c557t-7518d057681a2c1f0fed77e822739e41b93d9a94894a3400fa295779e3b6ebc43</originalsourceid><addsrcrecordid>eNqN0s1LIzEYBvAgK251PXtxYU7iwdF8TCbJ0RatQtkedvUa0sw7ZWQmcZMp2v3rN9JBKfRQcgjk-SUQ3gehM4KvCaHlTbQNOAvXoiyJkuIAjQhWPFcUs29ohDErc4kF_46OY3zBOGWKHaGjgY8Qnbts5t_ysQmhgZA9rKvgl-CysXdVzIyrsjv3b91BNjG9adexiT_QYW3aCKfDfoKe7u_-TB7y2Xz6OLmd5ZZz0eeCE1lhLkpJDLWkxjVUQoCkVDAFBVkoVimjCqkKwwqMa0MVF0IBW5SwsAU7QRebd1-D_7uC2OuuiRba1jjwq6iFYJLggid4tYFL04JuXO37YGz6BATTegd1k45viaCypJwmnu_gaVXQNXaXv9zyifTw3i_NKkb9-PvX3nT-vDcdT_elcjrbole7qPVtC0vQaT6T-Ra_2XAbfIwBav0ams6EtSZYf_RLD_3SQ2HSjZ_DUFaLDqpP_5Wfb_KX2PvwGVMpFSk5-w9eAc8r</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>77381045</pqid></control><display><type>article</type><title>On Low-Barrier Hydrogen Bonds and Enzyme Catalysis</title><source>MEDLINE</source><source>JSTOR Archive Collection A-Z Listing</source><source>American Association for the Advancement of Science</source><creator>Warshel, Arieh ; Papazyan, Arno ; Kollman, Peter A. ; Cleland, W. W. ; Kreevoy, Maurice M. ; Frey, Perry A.</creator><creatorcontrib>Warshel, Arieh ; Papazyan, Arno ; Kollman, Peter A. ; Cleland, W. W. ; Kreevoy, Maurice M. ; Frey, Perry A.</creatorcontrib><description>The contention that low-barrier hydrogen bonds support enzyme catalysis by means of 'resonance stabilization' is disputed. It is suggested that an opposite, destabilization process occurs. Two replies are included.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.7661987</identifier><identifier>PMID: 7661987</identifier><language>eng</language><publisher>United States: American Society for the Advancement of Science</publisher><subject>Active sites ; Binding Sites ; Carboxylic acids ; Catalysis ; Chemical Phenomena ; Chemistry, Physical ; Electrostatics ; Enzyme kinetics ; Enzymes ; Enzymes - metabolism ; Free energy ; Hydrogen Bonding ; Hydrogen bonds ; Hydrogen-Ion Concentration ; Molecules ; Protons ; Solvents ; Technical Comments</subject><ispartof>Science (American Association for the Advancement of Science), 1995-07, Vol.269 (5220), p.102-106</ispartof><rights>Copyright 1995 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1995 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1995 American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c557t-7518d057681a2c1f0fed77e822739e41b93d9a94894a3400fa295779e3b6ebc43</citedby><cites>FETCH-LOGICAL-c557t-7518d057681a2c1f0fed77e822739e41b93d9a94894a3400fa295779e3b6ebc43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2889165$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2889165$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,2884,2885,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7661987$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Warshel, Arieh</creatorcontrib><creatorcontrib>Papazyan, Arno</creatorcontrib><creatorcontrib>Kollman, Peter A.</creatorcontrib><creatorcontrib>Cleland, W. W.</creatorcontrib><creatorcontrib>Kreevoy, Maurice M.</creatorcontrib><creatorcontrib>Frey, Perry A.</creatorcontrib><title>On Low-Barrier Hydrogen Bonds and Enzyme Catalysis</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>The contention that low-barrier hydrogen bonds support enzyme catalysis by means of 'resonance stabilization' is disputed. It is suggested that an opposite, destabilization process occurs. Two replies are included.</description><subject>Active sites</subject><subject>Binding Sites</subject><subject>Carboxylic acids</subject><subject>Catalysis</subject><subject>Chemical Phenomena</subject><subject>Chemistry, Physical</subject><subject>Electrostatics</subject><subject>Enzyme kinetics</subject><subject>Enzymes</subject><subject>Enzymes - metabolism</subject><subject>Free energy</subject><subject>Hydrogen Bonding</subject><subject>Hydrogen bonds</subject><subject>Hydrogen-Ion Concentration</subject><subject>Molecules</subject><subject>Protons</subject><subject>Solvents</subject><subject>Technical Comments</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0s1LIzEYBvAgK251PXtxYU7iwdF8TCbJ0RatQtkedvUa0sw7ZWQmcZMp2v3rN9JBKfRQcgjk-SUQ3gehM4KvCaHlTbQNOAvXoiyJkuIAjQhWPFcUs29ohDErc4kF_46OY3zBOGWKHaGjgY8Qnbts5t_ysQmhgZA9rKvgl-CysXdVzIyrsjv3b91BNjG9adexiT_QYW3aCKfDfoKe7u_-TB7y2Xz6OLmd5ZZz0eeCE1lhLkpJDLWkxjVUQoCkVDAFBVkoVimjCqkKwwqMa0MVF0IBW5SwsAU7QRebd1-D_7uC2OuuiRba1jjwq6iFYJLggid4tYFL04JuXO37YGz6BATTegd1k45viaCypJwmnu_gaVXQNXaXv9zyifTw3i_NKkb9-PvX3nT-vDcdT_elcjrbole7qPVtC0vQaT6T-Ra_2XAbfIwBav0ams6EtSZYf_RLD_3SQ2HSjZ_DUFaLDqpP_5Wfb_KX2PvwGVMpFSk5-w9eAc8r</recordid><startdate>19950707</startdate><enddate>19950707</enddate><creator>Warshel, Arieh</creator><creator>Papazyan, Arno</creator><creator>Kollman, Peter A.</creator><creator>Cleland, W. W.</creator><creator>Kreevoy, Maurice M.</creator><creator>Frey, Perry A.</creator><general>American Society for the Advancement of Science</general><general>American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>7X8</scope></search><sort><creationdate>19950707</creationdate><title>On Low-Barrier Hydrogen Bonds and Enzyme Catalysis</title><author>Warshel, Arieh ; Papazyan, Arno ; Kollman, Peter A. ; Cleland, W. W. ; Kreevoy, Maurice M. ; Frey, Perry A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c557t-7518d057681a2c1f0fed77e822739e41b93d9a94894a3400fa295779e3b6ebc43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Active sites</topic><topic>Binding Sites</topic><topic>Carboxylic acids</topic><topic>Catalysis</topic><topic>Chemical Phenomena</topic><topic>Chemistry, Physical</topic><topic>Electrostatics</topic><topic>Enzyme kinetics</topic><topic>Enzymes</topic><topic>Enzymes - metabolism</topic><topic>Free energy</topic><topic>Hydrogen Bonding</topic><topic>Hydrogen bonds</topic><topic>Hydrogen-Ion Concentration</topic><topic>Molecules</topic><topic>Protons</topic><topic>Solvents</topic><topic>Technical Comments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Warshel, Arieh</creatorcontrib><creatorcontrib>Papazyan, Arno</creatorcontrib><creatorcontrib>Kollman, Peter A.</creatorcontrib><creatorcontrib>Cleland, W. W.</creatorcontrib><creatorcontrib>Kreevoy, Maurice M.</creatorcontrib><creatorcontrib>Frey, Perry A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>Gale In Context: Biography</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Canada</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Warshel, Arieh</au><au>Papazyan, Arno</au><au>Kollman, Peter A.</au><au>Cleland, W. W.</au><au>Kreevoy, Maurice M.</au><au>Frey, Perry A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>On Low-Barrier Hydrogen Bonds and Enzyme Catalysis</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1995-07-07</date><risdate>1995</risdate><volume>269</volume><issue>5220</issue><spage>102</spage><epage>106</epage><pages>102-106</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>The contention that low-barrier hydrogen bonds support enzyme catalysis by means of 'resonance stabilization' is disputed. It is suggested that an opposite, destabilization process occurs. Two replies are included.</abstract><cop>United States</cop><pub>American Society for the Advancement of Science</pub><pmid>7661987</pmid><doi>10.1126/science.7661987</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1995-07, Vol.269 (5220), p.102-106 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77381045 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; American Association for the Advancement of Science |
| subjects | Active sites Binding Sites Carboxylic acids Catalysis Chemical Phenomena Chemistry, Physical Electrostatics Enzyme kinetics Enzymes Enzymes - metabolism Free energy Hydrogen Bonding Hydrogen bonds Hydrogen-Ion Concentration Molecules Protons Solvents Technical Comments |
| title | On Low-Barrier Hydrogen Bonds and Enzyme Catalysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T04%3A54%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=On%20Low-Barrier%20Hydrogen%20Bonds%20and%20Enzyme%20Catalysis&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Warshel,%20Arieh&rft.date=1995-07-07&rft.volume=269&rft.issue=5220&rft.spage=102&rft.epage=106&rft.pages=102-106&rft.issn=0036-8075&rft.eissn=1095-9203&rft_id=info:doi/10.1126/science.7661987&rft_dat=%3Cgale_proqu%3EA17286252%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=77381045&rft_id=info:pmid/7661987&rft_galeid=A17286252&rft_jstor_id=2889165&rfr_iscdi=true |