On Low-Barrier Hydrogen Bonds and Enzyme Catalysis

On Low-Barrier Hydrogen Bonds and Enzyme Catalysis

The contention that low-barrier hydrogen bonds support enzyme catalysis by means of 'resonance stabilization' is disputed. It is suggested that an opposite, destabilization process occurs. Two replies are included.

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Bibliographische Detailangaben
Veröffentlicht in:Science (American Association for the Advancement of Science) 1995-07, Vol.269 (5220), p.102-106
Hauptverfasser: Warshel, Arieh, Papazyan, Arno, Kollman, Peter A., Cleland, W. W., Kreevoy, Maurice M., Frey, Perry A.
Format: Artikel
Sprache:eng
Schlagworte:
Active sites
Binding Sites
Carboxylic acids
Catalysis
Chemical Phenomena
Chemistry, Physical
Electrostatics
Enzyme kinetics
Enzymes
Enzymes - metabolism
Free energy
Hydrogen Bonding
Hydrogen bonds
Hydrogen-Ion Concentration
Molecules
Protons
Solvents
Technical Comments
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Beschreibung
Zusammenfassung:The contention that low-barrier hydrogen bonds support enzyme catalysis by means of 'resonance stabilization' is disputed. It is suggested that an opposite, destabilization process occurs. Two replies are included.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.7661987