Serum IgE antibodies to Trichophyton in patients with urticaria, angioedema, asthma, and rhinitis: Development of a radioallergosorbent test
A series of patients was identified who demonstrated immediate positive skin tests to intradermal Trichophyton extract. These skin responses did not correlate with other fungal skin tests and were present both in atopic and nonatopic patients. The individuals demonstrating positive immediate skin te...
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| Veröffentlicht in: | Journal of allergy and clinical immunology 1987, Vol.79 (1), p.40-45 |
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| container_title | Journal of allergy and clinical immunology |
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| creator | Platts-Mills, Thomas A.E. Fiocco, Guy P. Hayden, Mary L. Guerrant, John L. Pollart, Susan M. Wilkins, Susan R. |
| description | A series of patients was identified who demonstrated immediate positive skin tests to intradermal
Trichophyton extract. These skin responses did not correlate with other fungal skin tests and were present both in atopic and nonatopic patients. The individuals demonstrating positive immediate skin tests included patients with urticaria, angioedema, asthma, and/or rhinitis, as well as five of 34 normal control subjects. Most skin test positive individuals had a history of local fungal infection and clinical signs suggestive of fungal infection. By use of
Trichophyton tonsurans extract linked to Sepharose as the immunosorbent, it was possible to measure IgE antibodies in 26/30 sera from skin test positive individuals. With strongly positive sera, RAST bound up to 30% of the radiolabeled anti-IgE added. The results confirm that most skin test positive individuals have IgE-mediated hypersensitivity to
Trichophyton. These observations support the older view that absorption of dermatophyte allergen through the skin should be considered as a possible cause of allergic disease. |
| doi_str_mv | 10.1016/S0091-6749(87)80014-3 |
| format | Article |
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Trichophyton extract. These skin responses did not correlate with other fungal skin tests and were present both in atopic and nonatopic patients. The individuals demonstrating positive immediate skin tests included patients with urticaria, angioedema, asthma, and/or rhinitis, as well as five of 34 normal control subjects. Most skin test positive individuals had a history of local fungal infection and clinical signs suggestive of fungal infection. By use of
Trichophyton tonsurans extract linked to Sepharose as the immunosorbent, it was possible to measure IgE antibodies in 26/30 sera from skin test positive individuals. With strongly positive sera, RAST bound up to 30% of the radiolabeled anti-IgE added. The results confirm that most skin test positive individuals have IgE-mediated hypersensitivity to
Trichophyton. These observations support the older view that absorption of dermatophyte allergen through the skin should be considered as a possible cause of allergic disease.</description><identifier>ISSN: 0091-6749</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/S0091-6749(87)80014-3</identifier><identifier>PMID: 3805546</identifier><identifier>CODEN: JACIBY</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Allergic diseases ; Angioedema - immunology ; Antibodies, Fungal - analysis ; Asthma - immunology ; Biological and medical sciences ; Humans ; Immunoglobulin E - analysis ; Immunopathology ; Medical sciences ; Radioallergosorbent Test - methods ; Radioimmunoassay - methods ; Respiratory and ent allergic diseases ; Rhinitis - immunology ; Skin Tests ; Trichophyton ; Trichophyton - immunology ; Urticaria - immunology</subject><ispartof>Journal of allergy and clinical immunology, 1987, Vol.79 (1), p.40-45</ispartof><rights>1987 The C. V. Mosby Company</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c449t-6d116dfe0fe738d74f8e2cab37eaaedd0d20b7b1b7d26b7611e1067f05fc22a73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0091-6749(87)80014-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,4022,27922,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8042887$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3805546$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Platts-Mills, Thomas A.E.</creatorcontrib><creatorcontrib>Fiocco, Guy P.</creatorcontrib><creatorcontrib>Hayden, Mary L.</creatorcontrib><creatorcontrib>Guerrant, John L.</creatorcontrib><creatorcontrib>Pollart, Susan M.</creatorcontrib><creatorcontrib>Wilkins, Susan R.</creatorcontrib><title>Serum IgE antibodies to Trichophyton in patients with urticaria, angioedema, asthma, and rhinitis: Development of a radioallergosorbent test</title><title>Journal of allergy and clinical immunology</title><addtitle>J Allergy Clin Immunol</addtitle><description>A series of patients was identified who demonstrated immediate positive skin tests to intradermal
Trichophyton extract. These skin responses did not correlate with other fungal skin tests and were present both in atopic and nonatopic patients. The individuals demonstrating positive immediate skin tests included patients with urticaria, angioedema, asthma, and/or rhinitis, as well as five of 34 normal control subjects. Most skin test positive individuals had a history of local fungal infection and clinical signs suggestive of fungal infection. By use of
Trichophyton tonsurans extract linked to Sepharose as the immunosorbent, it was possible to measure IgE antibodies in 26/30 sera from skin test positive individuals. With strongly positive sera, RAST bound up to 30% of the radiolabeled anti-IgE added. The results confirm that most skin test positive individuals have IgE-mediated hypersensitivity to
Trichophyton. These observations support the older view that absorption of dermatophyte allergen through the skin should be considered as a possible cause of allergic disease.</description><subject>Allergic diseases</subject><subject>Angioedema - immunology</subject><subject>Antibodies, Fungal - analysis</subject><subject>Asthma - immunology</subject><subject>Biological and medical sciences</subject><subject>Humans</subject><subject>Immunoglobulin E - analysis</subject><subject>Immunopathology</subject><subject>Medical sciences</subject><subject>Radioallergosorbent Test - methods</subject><subject>Radioimmunoassay - methods</subject><subject>Respiratory and ent allergic diseases</subject><subject>Rhinitis - immunology</subject><subject>Skin Tests</subject><subject>Trichophyton</subject><subject>Trichophyton - immunology</subject><subject>Urticaria - immunology</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9u1DAQxi0EKkvhESr5gBBIBOz8sR0uCJUClSpxaDlbjj3ZDErixXaK-g48NM7uaq89ja3v-2bs-RFywdkHzrj4eMtYywsh6_atku8UY7wuqidkw1krC6HK5inZnCzPyYsYf7N8r1R7Rs4qxZqmFhvy7xbCMtHr7RU1c8LOO4RIk6d3Ae3gd8ND8jPFme5MQphTpH8xDXQJCa0JaN7n2BY9OJjWc0zDvs6OhgFnTBg_0a9wD6PfTTlOfU8NDcahN-MIYeujD90qJIjpJXnWmzHCq2M9J7--Xd1d_ihufn6_vvxyU9i6blMhHOfC9cB6kJVysu4VlNZ0lQRjwDnmStbJjnfSlaKTgnPgTMieNb0tSyOrc_Lm0HcX_J8lD9YTRgvjaGbwS9Qyt82bax818lo0rFQsG5uD0QYfY4Be7wJOJjxozvSKS-9x6ZWFVlLvcekq5y6OA5ZuAndKHflk_fVRN9GasQ9mthhPNsXqUqn1Q58PNshbu0cIOtpMy4LDADZp5_GRh_wHSZS0Zw</recordid><startdate>1987</startdate><enddate>1987</enddate><creator>Platts-Mills, Thomas A.E.</creator><creator>Fiocco, Guy P.</creator><creator>Hayden, Mary L.</creator><creator>Guerrant, John L.</creator><creator>Pollart, Susan M.</creator><creator>Wilkins, Susan R.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>1987</creationdate><title>Serum IgE antibodies to Trichophyton in patients with urticaria, angioedema, asthma, and rhinitis: Development of a radioallergosorbent test</title><author>Platts-Mills, Thomas A.E. ; Fiocco, Guy P. ; Hayden, Mary L. ; Guerrant, John L. ; Pollart, Susan M. ; Wilkins, Susan R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c449t-6d116dfe0fe738d74f8e2cab37eaaedd0d20b7b1b7d26b7611e1067f05fc22a73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Allergic diseases</topic><topic>Angioedema - immunology</topic><topic>Antibodies, Fungal - analysis</topic><topic>Asthma - immunology</topic><topic>Biological and medical sciences</topic><topic>Humans</topic><topic>Immunoglobulin E - analysis</topic><topic>Immunopathology</topic><topic>Medical sciences</topic><topic>Radioallergosorbent Test - methods</topic><topic>Radioimmunoassay - methods</topic><topic>Respiratory and ent allergic diseases</topic><topic>Rhinitis - immunology</topic><topic>Skin Tests</topic><topic>Trichophyton</topic><topic>Trichophyton - immunology</topic><topic>Urticaria - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Platts-Mills, Thomas A.E.</creatorcontrib><creatorcontrib>Fiocco, Guy P.</creatorcontrib><creatorcontrib>Hayden, Mary L.</creatorcontrib><creatorcontrib>Guerrant, John L.</creatorcontrib><creatorcontrib>Pollart, Susan M.</creatorcontrib><creatorcontrib>Wilkins, Susan R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Platts-Mills, Thomas A.E.</au><au>Fiocco, Guy P.</au><au>Hayden, Mary L.</au><au>Guerrant, John L.</au><au>Pollart, Susan M.</au><au>Wilkins, Susan R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum IgE antibodies to Trichophyton in patients with urticaria, angioedema, asthma, and rhinitis: Development of a radioallergosorbent test</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>1987</date><risdate>1987</risdate><volume>79</volume><issue>1</issue><spage>40</spage><epage>45</epage><pages>40-45</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><coden>JACIBY</coden><abstract>A series of patients was identified who demonstrated immediate positive skin tests to intradermal
Trichophyton extract. These skin responses did not correlate with other fungal skin tests and were present both in atopic and nonatopic patients. The individuals demonstrating positive immediate skin tests included patients with urticaria, angioedema, asthma, and/or rhinitis, as well as five of 34 normal control subjects. Most skin test positive individuals had a history of local fungal infection and clinical signs suggestive of fungal infection. By use of
Trichophyton tonsurans extract linked to Sepharose as the immunosorbent, it was possible to measure IgE antibodies in 26/30 sera from skin test positive individuals. With strongly positive sera, RAST bound up to 30% of the radiolabeled anti-IgE added. The results confirm that most skin test positive individuals have IgE-mediated hypersensitivity to
Trichophyton. These observations support the older view that absorption of dermatophyte allergen through the skin should be considered as a possible cause of allergic disease.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>3805546</pmid><doi>10.1016/S0091-6749(87)80014-3</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of allergy and clinical immunology, 1987, Vol.79 (1), p.40-45 |
| issn | 0091-6749 1097-6825 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ScienceDirect Journals (5 years ago - present) |
| subjects | Allergic diseases Angioedema - immunology Antibodies, Fungal - analysis Asthma - immunology Biological and medical sciences Humans Immunoglobulin E - analysis Immunopathology Medical sciences Radioallergosorbent Test - methods Radioimmunoassay - methods Respiratory and ent allergic diseases Rhinitis - immunology Skin Tests Trichophyton Trichophyton - immunology Urticaria - immunology |
| title | Serum IgE antibodies to Trichophyton in patients with urticaria, angioedema, asthma, and rhinitis: Development of a radioallergosorbent test |
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