Jun-B expression in Purkinje cells by conjunctive stimulation of climbing fibre and AMPA
CO-APPLICATION of α-amino-3-hydro-5-methyl-4-isoxazole-propionate (AMPA) and 8-bromo cGMP (8-Br-cGMP) which cause long-term desensitization also induces c-Fos and Jun-B expression in Purkinje cells of cerebellar slices [Nakazawa K, Karachot L, Nakabeppu Y et al. NeuroReport 4, 1275–1278 (1993)]. Her...
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| Veröffentlicht in: | Neuroreport 1995-03, Vol.6 (5), p.793-796 |
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| creator | Yamamori, Tetsuo Mikawa, Sumiko Kado, Raymond |
| description | CO-APPLICATION of α-amino-3-hydro-5-methyl-4-isoxazole-propionate (AMPA) and 8-bromo cGMP (8-Br-cGMP) which cause long-term desensitization also induces c-Fos and Jun-B expression in Purkinje cells of cerebellar slices [Nakazawa K, Karachot L, Nakabeppu Y et al. NeuroReport 4, 1275–1278 (1993)]. Here, we report an increased local induction of Jun-B immunoreactivity in Purkinje cells in vivo when electrical stimulation of the inferior olive nucleus (IOn) was conjunctively applied with AMPA on the vermis. The present data further supports the idea that conjunctive heterosynaptic inputs to cerebellar Purkinje cells can trigger active gene transcription thus possibly contributing to cerebellar long-term plasticity. They also demonstrate that Jun-B may be a useful transcriptional marker to study cerebellar coincidence phenomena. |
| doi_str_mv | 10.1097/00001756-199503270-00022 |
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NeuroReport 4, 1275–1278 (1993)]. Here, we report an increased local induction of Jun-B immunoreactivity in Purkinje cells in vivo when electrical stimulation of the inferior olive nucleus (IOn) was conjunctively applied with AMPA on the vermis. The present data further supports the idea that conjunctive heterosynaptic inputs to cerebellar Purkinje cells can trigger active gene transcription thus possibly contributing to cerebellar long-term plasticity. They also demonstrate that Jun-B may be a useful transcriptional marker to study cerebellar coincidence phenomena.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/00001756-199503270-00022</identifier><identifier>PMID: 7541656</identifier><language>eng</language><publisher>Hagerstown, MD: Wolters Kluwer Health | Lippincott Williams & Wilkins</publisher><subject>Afferent Pathways - drug effects ; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - pharmacology ; Animals ; Biological and medical sciences ; Central nervous system ; Central neurotransmission. Neuromudulation. Pathways and receptors ; Electric Stimulation ; Fundamental and applied biological sciences. 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NeuroReport 4, 1275–1278 (1993)]. Here, we report an increased local induction of Jun-B immunoreactivity in Purkinje cells in vivo when electrical stimulation of the inferior olive nucleus (IOn) was conjunctively applied with AMPA on the vermis. The present data further supports the idea that conjunctive heterosynaptic inputs to cerebellar Purkinje cells can trigger active gene transcription thus possibly contributing to cerebellar long-term plasticity. They also demonstrate that Jun-B may be a useful transcriptional marker to study cerebellar coincidence phenomena.</description><subject>Afferent Pathways - drug effects</subject><subject>alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Central nervous system</subject><subject>Central neurotransmission. Neuromudulation. Pathways and receptors</subject><subject>Electric Stimulation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Genes, Immediate-Early</subject><subject>Genes, jun</subject><subject>Long-Term Potentiation - drug effects</subject><subject>Nerve Fibers - drug effects</subject><subject>Purkinje Cells - drug effects</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Stimulation, Chemical</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu3CAQQFHVKtls-wmVOES9OWUMGDhuoiZplao55JAbAowbNhhvwG6Sv6-3u91bVQ4gMW-GmQdCGMgZECU-k3mB4E0FSnFCa0Gq-aau36AFMEErzuX9W7QgiquKqYYfo5NS1jOiCMgjdCQ4g4Y3C3T_bUrVOfYvm-xLCUPCIeHbKT-GtPbY-RgLtq_YDWk9JTeGXx6XMfRTNOMWHjrsYuhtSD9xF2z22KQWr77frt6jd52JxX_Yn0t0d_nl7uK6uvlx9fVidVM5Bryu2q6RlgOlwhorqQUwChqwEjxnqm4doa6jTEjXGKNEC8IbgM60hnlOCV2iT7uymzw8Tb6Mug9l27ZJfpiKFoIKqdj_QWgElfW8LZHcgS4PpWTf6U0OvcmvGojeytd_5euDfP1H_pz6cf_GZHvfHhL3tuf46T5uijOxyya5UA7Ydsy52IyxHfY8xNHn8hinZ5_1gzdxfND_-nr6G96tm0s</recordid><startdate>19950327</startdate><enddate>19950327</enddate><creator>Yamamori, Tetsuo</creator><creator>Mikawa, Sumiko</creator><creator>Kado, Raymond</creator><general>Wolters Kluwer Health | Lippincott Williams & Wilkins</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19950327</creationdate><title>Jun-B expression in Purkinje cells by conjunctive stimulation of climbing fibre and AMPA</title><author>Yamamori, Tetsuo ; Mikawa, Sumiko ; Kado, Raymond</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4152-df68b51337bab83b11a9161b81e5492dc03cf3478c6aa97d17ea11fada4e5303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Afferent Pathways - drug effects</topic><topic>alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - pharmacology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Central nervous system</topic><topic>Central neurotransmission. Neuromudulation. Pathways and receptors</topic><topic>Electric Stimulation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Genes, Immediate-Early</topic><topic>Genes, jun</topic><topic>Long-Term Potentiation - drug effects</topic><topic>Nerve Fibers - drug effects</topic><topic>Purkinje Cells - drug effects</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Stimulation, Chemical</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamamori, Tetsuo</creatorcontrib><creatorcontrib>Mikawa, Sumiko</creatorcontrib><creatorcontrib>Kado, Raymond</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamamori, Tetsuo</au><au>Mikawa, Sumiko</au><au>Kado, Raymond</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Jun-B expression in Purkinje cells by conjunctive stimulation of climbing fibre and AMPA</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>1995-03-27</date><risdate>1995</risdate><volume>6</volume><issue>5</issue><spage>793</spage><epage>796</epage><pages>793-796</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>CO-APPLICATION of α-amino-3-hydro-5-methyl-4-isoxazole-propionate (AMPA) and 8-bromo cGMP (8-Br-cGMP) which cause long-term desensitization also induces c-Fos and Jun-B expression in Purkinje cells of cerebellar slices [Nakazawa K, Karachot L, Nakabeppu Y et al. NeuroReport 4, 1275–1278 (1993)]. Here, we report an increased local induction of Jun-B immunoreactivity in Purkinje cells in vivo when electrical stimulation of the inferior olive nucleus (IOn) was conjunctively applied with AMPA on the vermis. The present data further supports the idea that conjunctive heterosynaptic inputs to cerebellar Purkinje cells can trigger active gene transcription thus possibly contributing to cerebellar long-term plasticity. They also demonstrate that Jun-B may be a useful transcriptional marker to study cerebellar coincidence phenomena.</abstract><cop>Hagerstown, MD</cop><pub>Wolters Kluwer Health | Lippincott Williams & Wilkins</pub><pmid>7541656</pmid><doi>10.1097/00001756-199503270-00022</doi><tpages>4</tpages></addata></record> |
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| ispartof | Neuroreport, 1995-03, Vol.6 (5), p.793-796 |
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| subjects | Afferent Pathways - drug effects alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - pharmacology Animals Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Electric Stimulation Fundamental and applied biological sciences. Psychology Gene Expression Regulation - drug effects Genes, Immediate-Early Genes, jun Long-Term Potentiation - drug effects Nerve Fibers - drug effects Purkinje Cells - drug effects Rats Rats, Wistar Stimulation, Chemical Vertebrates: nervous system and sense organs |
| title | Jun-B expression in Purkinje cells by conjunctive stimulation of climbing fibre and AMPA |
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