The effect of prophylactic antibiotics on iatrogenic intervertebral disc infections : a rabbit model
A rabbit model was used to test the efficacy of two commonly used prophylactic antibiotics, cefazolin and vancomycin, in preventing iatrogenically introduced Staphylococcus aureus intervertebral disc infections. This study was performed to assess the efficacy of two prophylactic antibiotics in preve...
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| Veröffentlicht in: | Spine (Philadelphia, PA. 1976) PA. 1976), 1995-03, Vol.20 (6), p.685-688 |
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| container_title | Spine (Philadelphia, PA. 1976) |
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| creator | GUIBOUX, J.-P CANTOR, J. B SMALL, S. D ZERVOS, M HERKOWITZ, H. N |
| description | A rabbit model was used to test the efficacy of two commonly used prophylactic antibiotics, cefazolin and vancomycin, in preventing iatrogenically introduced Staphylococcus aureus intervertebral disc infections.
This study was performed to assess the efficacy of two prophylactic antibiotics in preventing iatrogenically introduced Staphylococcus aureus intervertebral disc infections.
Previous studies have had conflicting results regarding the penetration of antibiotics into the nucleus pulposus and their ability to eradicate infection.
In this study, 40 adult New Zealand White rabbits underwent inoculation of 10(1) or 10(3) Staphylococcus aureus/ml into 3-6 lumbar intervertebral discs under direct visualization. Either no antibiotics (control groups) or various preoperative and postoperative dosing schedules of cefazolin or vancomycin were given intravenously. Five days after surgery, the discs were harvested and cultured.
All 40 discs inoculated in the control groups became infected. None of the 35 discs inoculated in the cefazolin groups became infected. Infection developed in 23 of 107 discs inoculated in the vancomycin groups. Most notable of these were 17 of 17 positive cultures in animals given vancomycin 8 hours preoperatively only.
Based on these results, it was concluded that intravenous cefazolin or vancomycin given within 1 hour before surgery can effectively prevent postoperative discitis. No advantage was found with additional postoperative antibiotics. |
| doi_str_mv | 10.1097/00007632-199503150-00009 |
| format | Article |
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This study was performed to assess the efficacy of two prophylactic antibiotics in preventing iatrogenically introduced Staphylococcus aureus intervertebral disc infections.
Previous studies have had conflicting results regarding the penetration of antibiotics into the nucleus pulposus and their ability to eradicate infection.
In this study, 40 adult New Zealand White rabbits underwent inoculation of 10(1) or 10(3) Staphylococcus aureus/ml into 3-6 lumbar intervertebral discs under direct visualization. Either no antibiotics (control groups) or various preoperative and postoperative dosing schedules of cefazolin or vancomycin were given intravenously. Five days after surgery, the discs were harvested and cultured.
All 40 discs inoculated in the control groups became infected. None of the 35 discs inoculated in the cefazolin groups became infected. Infection developed in 23 of 107 discs inoculated in the vancomycin groups. Most notable of these were 17 of 17 positive cultures in animals given vancomycin 8 hours preoperatively only.
Based on these results, it was concluded that intravenous cefazolin or vancomycin given within 1 hour before surgery can effectively prevent postoperative discitis. No advantage was found with additional postoperative antibiotics.</description><identifier>ISSN: 0362-2436</identifier><identifier>EISSN: 1528-1159</identifier><identifier>DOI: 10.1097/00007632-199503150-00009</identifier><identifier>PMID: 7604344</identifier><identifier>CODEN: SPINDD</identifier><language>eng</language><publisher>Philadelphia, PA: Lippincott</publisher><subject>Animals ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Biological and medical sciences ; Cefazolin - therapeutic use ; Disease Models, Animal ; Iatrogenic Disease - prevention & control ; Injections, Intravenous ; Intervertebral Disc - drug effects ; Intervertebral Disc - microbiology ; Intervertebral Disc - surgery ; Medical sciences ; Pharmacology. Drug treatments ; Postoperative Complications - prevention & control ; Rabbits ; Spinal Diseases - microbiology ; Spinal Diseases - prevention & control ; Spinal Diseases - surgery ; Staphylococcal Infections - microbiology ; Staphylococcal Infections - prevention & control ; Staphylococcus aureus ; Vancomycin - therapeutic use</subject><ispartof>Spine (Philadelphia, PA. 1976), 1995-03, Vol.20 (6), p.685-688</ispartof><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,776,780,785,786,23909,23910,25118,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3524077$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7604344$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GUIBOUX, J.-P</creatorcontrib><creatorcontrib>CANTOR, J. B</creatorcontrib><creatorcontrib>SMALL, S. D</creatorcontrib><creatorcontrib>ZERVOS, M</creatorcontrib><creatorcontrib>HERKOWITZ, H. N</creatorcontrib><title>The effect of prophylactic antibiotics on iatrogenic intervertebral disc infections : a rabbit model</title><title>Spine (Philadelphia, PA. 1976)</title><addtitle>Spine (Phila Pa 1976)</addtitle><description>A rabbit model was used to test the efficacy of two commonly used prophylactic antibiotics, cefazolin and vancomycin, in preventing iatrogenically introduced Staphylococcus aureus intervertebral disc infections.
This study was performed to assess the efficacy of two prophylactic antibiotics in preventing iatrogenically introduced Staphylococcus aureus intervertebral disc infections.
Previous studies have had conflicting results regarding the penetration of antibiotics into the nucleus pulposus and their ability to eradicate infection.
In this study, 40 adult New Zealand White rabbits underwent inoculation of 10(1) or 10(3) Staphylococcus aureus/ml into 3-6 lumbar intervertebral discs under direct visualization. Either no antibiotics (control groups) or various preoperative and postoperative dosing schedules of cefazolin or vancomycin were given intravenously. Five days after surgery, the discs were harvested and cultured.
All 40 discs inoculated in the control groups became infected. None of the 35 discs inoculated in the cefazolin groups became infected. Infection developed in 23 of 107 discs inoculated in the vancomycin groups. Most notable of these were 17 of 17 positive cultures in animals given vancomycin 8 hours preoperatively only.
Based on these results, it was concluded that intravenous cefazolin or vancomycin given within 1 hour before surgery can effectively prevent postoperative discitis. No advantage was found with additional postoperative antibiotics.</description><subject>Animals</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Cefazolin - therapeutic use</subject><subject>Disease Models, Animal</subject><subject>Iatrogenic Disease - prevention & control</subject><subject>Injections, Intravenous</subject><subject>Intervertebral Disc - drug effects</subject><subject>Intervertebral Disc - microbiology</subject><subject>Intervertebral Disc - surgery</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Postoperative Complications - prevention & control</subject><subject>Rabbits</subject><subject>Spinal Diseases - microbiology</subject><subject>Spinal Diseases - prevention & control</subject><subject>Spinal Diseases - surgery</subject><subject>Staphylococcal Infections - microbiology</subject><subject>Staphylococcal Infections - prevention & control</subject><subject>Staphylococcus aureus</subject><subject>Vancomycin - therapeutic use</subject><issn>0362-2436</issn><issn>1528-1159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UE1LxDAQDaLo-vEThBzEWzVpmqTxJuIXCF70XKbpRCPdZk2ygv_eVNedywzvvfl6hFDOLjgz-pKV0ErUFTdGMsElq2bI7JAFl3VbcS7NLlkwoeqqboQ6IIcpfRSFEtzsk32tWCOaZkGGl3ek6BzaTIOjqxhW798j2OwthSn73odSJhom6iHH8IZTYfyUMX5hzNhHGOng04zNQ3yYEr2iQCP0vc90GQYcj8megzHhySYfkde725ebh-rp-f7x5vqpsoKLXCnL2r4GK9XgULl-0AMH1ypA22jXGqkb4D0CH8Awia2QqLQC5UT5kKMRR-T8b25543ONKXfLchmOI0wY1qnTWmilTF2E7Z_QxpBSRNetol9C_O4462aDu3-Du63Bv9C843SzY90vcdg2bhwt_NmGh2RhdBEm69NWJmTdsHLHDyLEhIc</recordid><startdate>19950315</startdate><enddate>19950315</enddate><creator>GUIBOUX, J.-P</creator><creator>CANTOR, J. B</creator><creator>SMALL, S. D</creator><creator>ZERVOS, M</creator><creator>HERKOWITZ, H. N</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19950315</creationdate><title>The effect of prophylactic antibiotics on iatrogenic intervertebral disc infections : a rabbit model</title><author>GUIBOUX, J.-P ; CANTOR, J. B ; SMALL, S. D ; ZERVOS, M ; HERKOWITZ, H. N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c313t-6c08b2ac56dfe6fbd7d1af86aec47f89574a1bea1da905e835e676a6f34361e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Biological and medical sciences</topic><topic>Cefazolin - therapeutic use</topic><topic>Disease Models, Animal</topic><topic>Iatrogenic Disease - prevention & control</topic><topic>Injections, Intravenous</topic><topic>Intervertebral Disc - drug effects</topic><topic>Intervertebral Disc - microbiology</topic><topic>Intervertebral Disc - surgery</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Postoperative Complications - prevention & control</topic><topic>Rabbits</topic><topic>Spinal Diseases - microbiology</topic><topic>Spinal Diseases - prevention & control</topic><topic>Spinal Diseases - surgery</topic><topic>Staphylococcal Infections - microbiology</topic><topic>Staphylococcal Infections - prevention & control</topic><topic>Staphylococcus aureus</topic><topic>Vancomycin - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GUIBOUX, J.-P</creatorcontrib><creatorcontrib>CANTOR, J. B</creatorcontrib><creatorcontrib>SMALL, S. D</creatorcontrib><creatorcontrib>ZERVOS, M</creatorcontrib><creatorcontrib>HERKOWITZ, H. 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N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of prophylactic antibiotics on iatrogenic intervertebral disc infections : a rabbit model</atitle><jtitle>Spine (Philadelphia, PA. 1976)</jtitle><addtitle>Spine (Phila Pa 1976)</addtitle><date>1995-03-15</date><risdate>1995</risdate><volume>20</volume><issue>6</issue><spage>685</spage><epage>688</epage><pages>685-688</pages><issn>0362-2436</issn><eissn>1528-1159</eissn><coden>SPINDD</coden><abstract>A rabbit model was used to test the efficacy of two commonly used prophylactic antibiotics, cefazolin and vancomycin, in preventing iatrogenically introduced Staphylococcus aureus intervertebral disc infections.
This study was performed to assess the efficacy of two prophylactic antibiotics in preventing iatrogenically introduced Staphylococcus aureus intervertebral disc infections.
Previous studies have had conflicting results regarding the penetration of antibiotics into the nucleus pulposus and their ability to eradicate infection.
In this study, 40 adult New Zealand White rabbits underwent inoculation of 10(1) or 10(3) Staphylococcus aureus/ml into 3-6 lumbar intervertebral discs under direct visualization. Either no antibiotics (control groups) or various preoperative and postoperative dosing schedules of cefazolin or vancomycin were given intravenously. Five days after surgery, the discs were harvested and cultured.
All 40 discs inoculated in the control groups became infected. None of the 35 discs inoculated in the cefazolin groups became infected. Infection developed in 23 of 107 discs inoculated in the vancomycin groups. Most notable of these were 17 of 17 positive cultures in animals given vancomycin 8 hours preoperatively only.
Based on these results, it was concluded that intravenous cefazolin or vancomycin given within 1 hour before surgery can effectively prevent postoperative discitis. No advantage was found with additional postoperative antibiotics.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>7604344</pmid><doi>10.1097/00007632-199503150-00009</doi><tpages>4</tpages></addata></record> |
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| ispartof | Spine (Philadelphia, PA. 1976), 1995-03, Vol.20 (6), p.685-688 |
| issn | 0362-2436 1528-1159 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Animals Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Cefazolin - therapeutic use Disease Models, Animal Iatrogenic Disease - prevention & control Injections, Intravenous Intervertebral Disc - drug effects Intervertebral Disc - microbiology Intervertebral Disc - surgery Medical sciences Pharmacology. Drug treatments Postoperative Complications - prevention & control Rabbits Spinal Diseases - microbiology Spinal Diseases - prevention & control Spinal Diseases - surgery Staphylococcal Infections - microbiology Staphylococcal Infections - prevention & control Staphylococcus aureus Vancomycin - therapeutic use |
| title | The effect of prophylactic antibiotics on iatrogenic intervertebral disc infections : a rabbit model |
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