In vivo immunopotentiating activity of thymopentin in aging humans: Increase of Il-2 production

The effect of thymopentin (TP-5) treatment on lymphocyte immune functions has been investigated in immunocompromized aged subjects. TP-5 was able to improve the cutaneous delayed hypersensitivity (CDH) to recall antigens and the proliferative response to phytohemagglutinin (PHA), concanavalin A, and...

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Veröffentlicht in:	Clinical immunology and immunopathology 1987-02, Vol.42 (2), p.151-159
Hauptverfasser:	Meroni, Pier Luigi, Barcellini, Wilma, Frasca, Daniela, Sguotti, Chiara, Borghi, M.Orietta, De Bartolo, Giovanni, Doria, Gino, Zanussi, Carlo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - pharmacology Adjuvants, Immunologic - therapeutic use Aged Aged, 80 and over Aging - immunology Antibodies, Monoclonal - immunology Biological and medical sciences Female Humans Immunologic Deficiency Syndromes - drug therapy Immunologic Deficiency Syndromes - immunology Immunologic Deficiency Syndromes - metabolism Immunomodulators Interleukin-2 - biosynthesis Lectins - pharmacology Lymphocyte Activation - drug effects Lymphocytes - classification Lymphocytes - drug effects Male Medical sciences Peptide Fragments - pharmacology Peptide Fragments - therapeutic use Pharmacology. Drug treatments Stimulation, Chemical Thymopentin Thymopoietins - pharmacology Thymopoietins - therapeutic use Thymus Hormones - pharmacology
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Zusammenfassung:	The effect of thymopentin (TP-5) treatment on lymphocyte immune functions has been investigated in immunocompromized aged subjects. TP-5 was able to improve the cutaneous delayed hypersensitivity (CDH) to recall antigens and the proliferative response to phytohemagglutinin (PHA), concanavalin A, and Pokeweed (PWM) as well as the PHA-induced interleukin-2 (Il-2) production. On the other hand, no detectable changes were induced by TP-5 treatment either on PWM-induced immunoglobulin synthesis or on lymphocyte subsets identified by monoclonal antibodies. Our results suggest that the enhancement of Il-2 synthesis might be a crucial mechanism of the immunopharmacological action of TP-5 in aging humans.
ISSN:	0090-1229 1090-2341
DOI:	10.1016/0090-1229(87)90002-X