Analysis of the interaction of antibodies with immunoglobulin idiotypes on neoplastic B lymphocytes: implications for immunotherapy

We have examined the reactions of a panel of nine monoclonal anti-idiotype antibodies with the surface immunoglobulin in situ on guinea pig L2C leukemic lymphocytes. Equilibrium binding constants were shown to range between 10(7) and 10(8) M-1 for univalent Fab' gamma fragments and between 10(8...

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Veröffentlicht in:	The Journal of immunology (1950) 1987-02, Vol.138 (3), p.981-988
Hauptverfasser:	Elliott, TJ, Glennie, MJ, McBride, HM, Stevenson, GT
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal tumors. Experimental tumors Animals Antibodies, Monoclonal - immunology Antibodies, Monoclonal - therapeutic use Antibody Affinity B-Lymphocytes - immunology Binding, Competitive Biological and medical sciences Epitopes - analysis Experimental malignant blood diseases Guinea Pigs Immunoglobulin G - metabolism Immunoglobulin Idiotypes - immunology Immunotherapy Leukemia, Experimental - immunology Leukemia, Experimental - therapy Medical sciences Metabolic Clearance Rate Receptors, Antigen, B-Cell - metabolism Temperature Time Factors Tumors
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