Serum vitamin B12 levels in patients with primary hepatocellular carcinoma during treatment with CB3717
Elevated Serum B12 levels were found at diagnosis in five of eleven patients with primary hepatocellular carcinoma. During chemotherapy either with CB3717 or VP16 the serum B12 rose dramatically, in one case reaching levels ten times the upper limit of normal. However, the serum LD activities did no...
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| Veröffentlicht in: | Journal of surgical oncology 1987-02, Vol.34 (2), p.100-103 |
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| container_end_page | 103 |
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| container_title | Journal of surgical oncology |
| container_volume | 34 |
| creator | Buamah, Paul K. James, Oliver F. W. Skillen, Andrew W. Harris, Adrian L. |
| description | Elevated Serum B12 levels were found at diagnosis in five of eleven patients with primary hepatocellular carcinoma. During chemotherapy either with CB3717 or VP16 the serum B12 rose dramatically, in one case reaching levels ten times the upper limit of normal. However, the serum LD activities did not change in parallel with the serum B12 levels suggesting that there was little necrosis of the tumour or the liver. With two out of five patients with other types of cancer the serum B12 levels also increased but less markedly. This data seems to suggest that the serum B12 level may not be as good a tumour marker for hepatocellular carcinoma as has been suggested and indeed may be influenced by the chemotherapeutic agent. |
| doi_str_mv | 10.1002/jso.2930340207 |
| format | Article |
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This data seems to suggest that the serum B12 level may not be as good a tumour marker for hepatocellular carcinoma as has been suggested and indeed may be influenced by the chemotherapeutic agent.</description><identifier>ISSN: 0022-4790</identifier><identifier>EISSN: 1096-9098</identifier><identifier>DOI: 10.1002/jso.2930340207</identifier><identifier>PMID: 2433545</identifier><identifier>CODEN: JSONAU</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Aged ; alpha-fetoprotein ; alpha-Fetoproteins - analysis ; Antineoplastic agents ; Biological and medical sciences ; Carcinoma, Hepatocellular - blood ; Carcinoma, Hepatocellular - drug therapy ; Carcinoma, Hepatocellular - surgery ; Chemotherapy ; Female ; Folic Acid - analogs & derivatives ; Folic Acid - therapeutic use ; Follow-Up Studies ; Humans ; L-Lactate Dehydrogenase - blood ; Liver Cirrhosis - blood ; Liver Neoplasms - blood ; Liver Neoplasms - drug therapy ; Liver Neoplasms - surgery ; Male ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; primary liver cell cancer ; Quinazolines - therapeutic use ; tumour marker ; Vitamin B 12 - blood ; Vitamin B12</subject><ispartof>Journal of surgical oncology, 1987-02, Vol.34 (2), p.100-103</ispartof><rights>Copyright © 1987 Wiley‐Liss, Inc., A Wiley Company</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjso.2930340207$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjso.2930340207$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7456091$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2433545$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Buamah, Paul K.</creatorcontrib><creatorcontrib>James, Oliver F. W.</creatorcontrib><creatorcontrib>Skillen, Andrew W.</creatorcontrib><creatorcontrib>Harris, Adrian L.</creatorcontrib><title>Serum vitamin B12 levels in patients with primary hepatocellular carcinoma during treatment with CB3717</title><title>Journal of surgical oncology</title><addtitle>J. Surg. Oncol</addtitle><description>Elevated Serum B12 levels were found at diagnosis in five of eleven patients with primary hepatocellular carcinoma. During chemotherapy either with CB3717 or VP16 the serum B12 rose dramatically, in one case reaching levels ten times the upper limit of normal. However, the serum LD activities did not change in parallel with the serum B12 levels suggesting that there was little necrosis of the tumour or the liver. With two out of five patients with other types of cancer the serum B12 levels also increased but less markedly. This data seems to suggest that the serum B12 level may not be as good a tumour marker for hepatocellular carcinoma as has been suggested and indeed may be influenced by the chemotherapeutic agent.</description><subject>Adult</subject><subject>Aged</subject><subject>alpha-fetoprotein</subject><subject>alpha-Fetoproteins - analysis</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Hepatocellular - blood</subject><subject>Carcinoma, Hepatocellular - drug therapy</subject><subject>Carcinoma, Hepatocellular - surgery</subject><subject>Chemotherapy</subject><subject>Female</subject><subject>Folic Acid - analogs & derivatives</subject><subject>Folic Acid - therapeutic use</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>L-Lactate Dehydrogenase - blood</subject><subject>Liver Cirrhosis - blood</subject><subject>Liver Neoplasms - blood</subject><subject>Liver Neoplasms - drug therapy</subject><subject>Liver Neoplasms - surgery</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>primary liver cell cancer</subject><subject>Quinazolines - therapeutic use</subject><subject>tumour marker</subject><subject>Vitamin B 12 - blood</subject><subject>Vitamin B12</subject><issn>0022-4790</issn><issn>1096-9098</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkc1v1DAQxS0EKtvClRuSD4hbytjjj_jIrqAFVfSwII7WbNZpXZLsYict_e9xtdHWF2vm_d5o7MfYOwHnAkB-usu7c-kQUIEE-4ItBDhTOXD1S7YogKyUdfCaneZ8BwDOGXXCTqRC1Eov2M06pKnn93GkPg58KSTvwn3oMi_VnsYYhjHzhzje8n2KPaVHfhtKf9eErps6Sryh1MRh1xPfTikON3xMgca--A621RKtsG_Yq5a6HN7O9xn79fXLz9VldXV98W31-aqKKNFWqEQ5kqgVdUvGbHVtNmA3QjsNCp02WtbOOo0OySoMjanbGimUngobwDP28TB3n3Z_p5BH38f8tCsNYTdlby1aaQQW8P0MTps-bP38Oj__TNE_zDrlhro20dDEfMSs0gacKJg7YA-xC49HWYB_SseXdPxzOv77-vq5Kt7q4I15DP-OXkp_vClrav_7x4V3azBGL9Fr_A9Au5A5</recordid><startdate>198702</startdate><enddate>198702</enddate><creator>Buamah, Paul K.</creator><creator>James, Oliver F. W.</creator><creator>Skillen, Andrew W.</creator><creator>Harris, Adrian L.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>198702</creationdate><title>Serum vitamin B12 levels in patients with primary hepatocellular carcinoma during treatment with CB3717</title><author>Buamah, Paul K. ; James, Oliver F. W. ; Skillen, Andrew W. ; Harris, Adrian L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i3237-3411112aaf18fa66d586b07b15950439565289795393a743ec68f83ae9794eb03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Adult</topic><topic>Aged</topic><topic>alpha-fetoprotein</topic><topic>alpha-Fetoproteins - analysis</topic><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Hepatocellular - blood</topic><topic>Carcinoma, Hepatocellular - drug therapy</topic><topic>Carcinoma, Hepatocellular - surgery</topic><topic>Chemotherapy</topic><topic>Female</topic><topic>Folic Acid - analogs & derivatives</topic><topic>Folic Acid - therapeutic use</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>L-Lactate Dehydrogenase - blood</topic><topic>Liver Cirrhosis - blood</topic><topic>Liver Neoplasms - blood</topic><topic>Liver Neoplasms - drug therapy</topic><topic>Liver Neoplasms - surgery</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>primary liver cell cancer</topic><topic>Quinazolines - therapeutic use</topic><topic>tumour marker</topic><topic>Vitamin B 12 - blood</topic><topic>Vitamin B12</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Buamah, Paul K.</creatorcontrib><creatorcontrib>James, Oliver F. W.</creatorcontrib><creatorcontrib>Skillen, Andrew W.</creatorcontrib><creatorcontrib>Harris, Adrian L.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Buamah, Paul K.</au><au>James, Oliver F. W.</au><au>Skillen, Andrew W.</au><au>Harris, Adrian L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum vitamin B12 levels in patients with primary hepatocellular carcinoma during treatment with CB3717</atitle><jtitle>Journal of surgical oncology</jtitle><addtitle>J. Surg. Oncol</addtitle><date>1987-02</date><risdate>1987</risdate><volume>34</volume><issue>2</issue><spage>100</spage><epage>103</epage><pages>100-103</pages><issn>0022-4790</issn><eissn>1096-9098</eissn><coden>JSONAU</coden><abstract>Elevated Serum B12 levels were found at diagnosis in five of eleven patients with primary hepatocellular carcinoma. During chemotherapy either with CB3717 or VP16 the serum B12 rose dramatically, in one case reaching levels ten times the upper limit of normal. However, the serum LD activities did not change in parallel with the serum B12 levels suggesting that there was little necrosis of the tumour or the liver. With two out of five patients with other types of cancer the serum B12 levels also increased but less markedly. This data seems to suggest that the serum B12 level may not be as good a tumour marker for hepatocellular carcinoma as has been suggested and indeed may be influenced by the chemotherapeutic agent.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>2433545</pmid><doi>10.1002/jso.2930340207</doi><tpages>4</tpages></addata></record> |
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| ispartof | Journal of surgical oncology, 1987-02, Vol.34 (2), p.100-103 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Aged alpha-fetoprotein alpha-Fetoproteins - analysis Antineoplastic agents Biological and medical sciences Carcinoma, Hepatocellular - blood Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - surgery Chemotherapy Female Folic Acid - analogs & derivatives Folic Acid - therapeutic use Follow-Up Studies Humans L-Lactate Dehydrogenase - blood Liver Cirrhosis - blood Liver Neoplasms - blood Liver Neoplasms - drug therapy Liver Neoplasms - surgery Male Medical sciences Middle Aged Pharmacology. Drug treatments primary liver cell cancer Quinazolines - therapeutic use tumour marker Vitamin B 12 - blood Vitamin B12 |
| title | Serum vitamin B12 levels in patients with primary hepatocellular carcinoma during treatment with CB3717 |
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