Sodium chlorite administration in long-evans rats: Reproductive and endocrine effects
Long-Evans rats, 4–6 weeks of age, were given access to 0, 1, 10, or 100 ppm sodium chlorite in deionized water ad libitum as drinking water. Males were exposed 56 days, and females for 14 days prior to breeding and throughout the 10-day breeding period. Males were evaluated for sperm parameters and...
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Veröffentlicht in: | Environmental research 1987-02, Vol.42 (1), p.238-245 |
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creator | Carlton, B.D. Habash, D.L. Basaran, A.H. George, E.L. Smith, M.K. |
description | Long-Evans rats, 4–6 weeks of age, were given access to 0, 1, 10, or 100 ppm sodium chlorite in deionized water
ad libitum as drinking water. Males were exposed 56 days, and females for 14 days prior to breeding and throughout the 10-day breeding period. Males were evaluated for sperm parameters and reproductive tract histopathology following the breeding period. Females were exposed throughout gestation and lactation. Dams and pups were necropsied at weaning. Decreases in serum T
3 and T
4 were observed on Postnatal Days 21 and 40 in male and female pups exposed to 100 ppm chlorite or above. Additionally, groups of males were exposed to 0, 10, 100, or 500 ppm
ad libitum in the drinking water to confirm observed subtle reproductive effects and examine dose-effect relationships. A significant increase in the percentage of abnormal sperm morphology (
P < 0.001) and decrease in sperm direct progressive movement (
P < 0.01) were observed for adult males at chlorite levels of 100 or 500 ppm. Since other clinical and reproductive endpoints were not affected, sperm morphology and sperm direct progressive movement may be two of the more sensitive indicators of reproductive damage. |
doi_str_mv | 10.1016/S0013-9351(87)80025-7 |
format | Article |
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ad libitum as drinking water. Males were exposed 56 days, and females for 14 days prior to breeding and throughout the 10-day breeding period. Males were evaluated for sperm parameters and reproductive tract histopathology following the breeding period. Females were exposed throughout gestation and lactation. Dams and pups were necropsied at weaning. Decreases in serum T
3 and T
4 were observed on Postnatal Days 21 and 40 in male and female pups exposed to 100 ppm chlorite or above. Additionally, groups of males were exposed to 0, 10, 100, or 500 ppm
ad libitum in the drinking water to confirm observed subtle reproductive effects and examine dose-effect relationships. A significant increase in the percentage of abnormal sperm morphology (
P < 0.001) and decrease in sperm direct progressive movement (
P < 0.01) were observed for adult males at chlorite levels of 100 or 500 ppm. Since other clinical and reproductive endpoints were not affected, sperm morphology and sperm direct progressive movement may be two of the more sensitive indicators of reproductive damage.</description><identifier>ISSN: 0013-9351</identifier><identifier>EISSN: 1096-0953</identifier><identifier>DOI: 10.1016/S0013-9351(87)80025-7</identifier><identifier>PMID: 3803340</identifier><identifier>CODEN: ENVRAL</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Chemical and industrial products toxicology. Toxic occupational diseases ; Drinking - drug effects ; Endocrine Glands - drug effects ; Female ; Fertility - drug effects ; Male ; Medical sciences ; Metals and various inorganic compounds ; Rats ; Rats, Inbred Strains ; Reproduction - drug effects ; Sodium Chloride - pharmacology ; Spermatozoa - drug effects ; Spermatozoa - ultrastructure ; Thyroid Hormones - blood ; Toxicology</subject><ispartof>Environmental research, 1987-02, Vol.42 (1), p.238-245</ispartof><rights>1987 Academic Press, Inc. All rights reserved</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-51bf52f386226e4e802671dd3f123690d1d6a83b8476f5d11cb8edf6dfe95c6e3</citedby><cites>FETCH-LOGICAL-c451t-51bf52f386226e4e802671dd3f123690d1d6a83b8476f5d11cb8edf6dfe95c6e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0013-9351(87)80025-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8262031$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3803340$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carlton, B.D.</creatorcontrib><creatorcontrib>Habash, D.L.</creatorcontrib><creatorcontrib>Basaran, A.H.</creatorcontrib><creatorcontrib>George, E.L.</creatorcontrib><creatorcontrib>Smith, M.K.</creatorcontrib><title>Sodium chlorite administration in long-evans rats: Reproductive and endocrine effects</title><title>Environmental research</title><addtitle>Environ Res</addtitle><description>Long-Evans rats, 4–6 weeks of age, were given access to 0, 1, 10, or 100 ppm sodium chlorite in deionized water
ad libitum as drinking water. Males were exposed 56 days, and females for 14 days prior to breeding and throughout the 10-day breeding period. Males were evaluated for sperm parameters and reproductive tract histopathology following the breeding period. Females were exposed throughout gestation and lactation. Dams and pups were necropsied at weaning. Decreases in serum T
3 and T
4 were observed on Postnatal Days 21 and 40 in male and female pups exposed to 100 ppm chlorite or above. Additionally, groups of males were exposed to 0, 10, 100, or 500 ppm
ad libitum in the drinking water to confirm observed subtle reproductive effects and examine dose-effect relationships. A significant increase in the percentage of abnormal sperm morphology (
P < 0.001) and decrease in sperm direct progressive movement (
P < 0.01) were observed for adult males at chlorite levels of 100 or 500 ppm. Since other clinical and reproductive endpoints were not affected, sperm morphology and sperm direct progressive movement may be two of the more sensitive indicators of reproductive damage.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Drinking - drug effects</subject><subject>Endocrine Glands - drug effects</subject><subject>Female</subject><subject>Fertility - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metals and various inorganic compounds</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Reproduction - drug effects</subject><subject>Sodium Chloride - pharmacology</subject><subject>Spermatozoa - drug effects</subject><subject>Spermatozoa - ultrastructure</subject><subject>Thyroid Hormones - blood</subject><subject>Toxicology</subject><issn>0013-9351</issn><issn>1096-0953</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU2LFDEQhoMo67j6Exb6IKKH1lTS-Wgviyx-wYLguueQSSoa6U7WpHvAf29mZ5jregpJPZV6qYeQC6BvgYJ8d0Mp8H7kAl5r9UZTykSvHpEN0FH2dBT8MdmckKfkWa2_2xUEp2fkjGvK-UA35PYm-7jOnfs15RIX7KyfY4p1KXaJOXUxdVNOP3vc2VS79ljfd9_xrmS_uiXuGp98h8lnV2LCDkNAt9Tn5EmwU8UXx_Oc3H76-OPqS3_97fPXqw_XvRsELL2AbRAscC0Zkzigpkwq8J4HYFyO1IOXVvOtHpQMwgO4rUYfpA84CieRn5NXh39boD8r1sXMsTqcJpswr9UoxRUdYHgQhEGO0DL9B8hAw7AHxQF0JddaMJi7Emdb_hqgZi_I3Asy--0brcy9IKNa38VxwLqd0Z-6jkZa_eWxbquzUyg2uVhPmGaSUb4ff3nAsK13F7GY6iImhz6WZsD4HB8I8g8cqaxb</recordid><startdate>19870201</startdate><enddate>19870201</enddate><creator>Carlton, B.D.</creator><creator>Habash, D.L.</creator><creator>Basaran, A.H.</creator><creator>George, E.L.</creator><creator>Smith, M.K.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>7U7</scope><scope>7X8</scope></search><sort><creationdate>19870201</creationdate><title>Sodium chlorite administration in long-evans rats: Reproductive and endocrine effects</title><author>Carlton, B.D. ; Habash, D.L. ; Basaran, A.H. ; George, E.L. ; Smith, M.K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-51bf52f386226e4e802671dd3f123690d1d6a83b8476f5d11cb8edf6dfe95c6e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Drinking - drug effects</topic><topic>Endocrine Glands - drug effects</topic><topic>Female</topic><topic>Fertility - drug effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metals and various inorganic compounds</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Reproduction - drug effects</topic><topic>Sodium Chloride - pharmacology</topic><topic>Spermatozoa - drug effects</topic><topic>Spermatozoa - ultrastructure</topic><topic>Thyroid Hormones - blood</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carlton, B.D.</creatorcontrib><creatorcontrib>Habash, D.L.</creatorcontrib><creatorcontrib>Basaran, A.H.</creatorcontrib><creatorcontrib>George, E.L.</creatorcontrib><creatorcontrib>Smith, M.K.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Toxicology Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Environmental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carlton, B.D.</au><au>Habash, D.L.</au><au>Basaran, A.H.</au><au>George, E.L.</au><au>Smith, M.K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sodium chlorite administration in long-evans rats: Reproductive and endocrine effects</atitle><jtitle>Environmental research</jtitle><addtitle>Environ Res</addtitle><date>1987-02-01</date><risdate>1987</risdate><volume>42</volume><issue>1</issue><spage>238</spage><epage>245</epage><pages>238-245</pages><issn>0013-9351</issn><eissn>1096-0953</eissn><coden>ENVRAL</coden><abstract>Long-Evans rats, 4–6 weeks of age, were given access to 0, 1, 10, or 100 ppm sodium chlorite in deionized water
ad libitum as drinking water. Males were exposed 56 days, and females for 14 days prior to breeding and throughout the 10-day breeding period. Males were evaluated for sperm parameters and reproductive tract histopathology following the breeding period. Females were exposed throughout gestation and lactation. Dams and pups were necropsied at weaning. Decreases in serum T
3 and T
4 were observed on Postnatal Days 21 and 40 in male and female pups exposed to 100 ppm chlorite or above. Additionally, groups of males were exposed to 0, 10, 100, or 500 ppm
ad libitum in the drinking water to confirm observed subtle reproductive effects and examine dose-effect relationships. A significant increase in the percentage of abnormal sperm morphology (
P < 0.001) and decrease in sperm direct progressive movement (
P < 0.01) were observed for adult males at chlorite levels of 100 or 500 ppm. Since other clinical and reproductive endpoints were not affected, sperm morphology and sperm direct progressive movement may be two of the more sensitive indicators of reproductive damage.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>3803340</pmid><doi>10.1016/S0013-9351(87)80025-7</doi><tpages>8</tpages></addata></record> |
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source | MEDLINE; Elsevier ScienceDirect Journals Complete |
subjects | Animals Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Drinking - drug effects Endocrine Glands - drug effects Female Fertility - drug effects Male Medical sciences Metals and various inorganic compounds Rats Rats, Inbred Strains Reproduction - drug effects Sodium Chloride - pharmacology Spermatozoa - drug effects Spermatozoa - ultrastructure Thyroid Hormones - blood Toxicology |
title | Sodium chlorite administration in long-evans rats: Reproductive and endocrine effects |
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