Different transforming growth factor-α species are derived from a glycosylated and palmitoylated transmembrane precursor

cDNA analysis has revealed that the 50 amino acid transforming growth factor-α (TGF-α) is derived from a 160 amino acid precursor. Antibodies to TGF-α and to a C-terminal portion of the precursor were used to study the biosynthesis and processing of the precursor. CHO cells transfected with a TGF-α...

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Veröffentlicht in:	Cell 1987-02, Vol.48 (3), p.429-440
Hauptverfasser:	Bringman, Timothy S., Lindquist, Patricia B., Derynck, Rik
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Cell Line Cell Membrane - metabolism Cricetinae Glycosylation Membrane Proteins - metabolism Palmitates - metabolism Peptides - immunology Peptides - metabolism Protein Precursors - immunology Protein Precursors - metabolism Protein Processing, Post-Translational Transforming Growth Factors
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