Evidence of Serological Cross-Reactivities with Human Immunodeficiency Virus Types 1 and 2 and Human T-Lymphotropic Virus Types I and II in Sera of Pregnant Women in Ibadan, Nigeria
Background. Our previous studies have indicated that the human immunodeficiency virus (HIV) and human T-Iymphotropic virus (HTLV) groups of retroviruses are endemic among various populations in Nigeria These viruses are antigenically distinct and antibodies to HIV and HTLV do not cross-react, so we...
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| Veröffentlicht in: | International journal of epidemiology 1995-02, Vol.24 (1), p.198-203 |
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| creator | OLALEYE, DAVID O EKWEOZOR, COMFORT C SHENG, ZHIJUAN RASHEED, SURAIYA |
| description | Background. Our previous studies have indicated that the human immunodeficiency virus (HIV) and human T-Iymphotropic virus (HTLV) groups of retroviruses are endemic among various populations in Nigeria These viruses are antigenically distinct and antibodies to HIV and HTLV do not cross-react, so we studied the prevalence of HIV-1, HIV-2, HTLV-I and HTLV-II antibodies in sera of pregnant women attending an antenatal clinic in Ibadan, Nigena. Methods. In all, 364 sera were screened using three different enzyme immunoassays, Including those that distinguished HIV-1 antibodies from HIV-2, and HTLV-I antibodies from HTLV-II. All repeatedly reactive sera were confirmed by Western blots and synthetic peptide assays for the respective viruses. Results. Overall, 71 sera (19.5%) had antibodies to HIV, HTLV or both groups of retroviruses. Most (95.8%) of the reactive samples were from women 20–29 years old. Two of five sera from individuals |
| doi_str_mv | 10.1093/ije/24.1.198 |
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Our previous studies have indicated that the human immunodeficiency virus (HIV) and human T-Iymphotropic virus (HTLV) groups of retroviruses are endemic among various populations in Nigeria These viruses are antigenically distinct and antibodies to HIV and HTLV do not cross-react, so we studied the prevalence of HIV-1, HIV-2, HTLV-I and HTLV-II antibodies in sera of pregnant women attending an antenatal clinic in Ibadan, Nigena. Methods. In all, 364 sera were screened using three different enzyme immunoassays, Including those that distinguished HIV-1 antibodies from HIV-2, and HTLV-I antibodies from HTLV-II. All repeatedly reactive sera were confirmed by Western blots and synthetic peptide assays for the respective viruses. Results. Overall, 71 sera (19.5%) had antibodies to HIV, HTLV or both groups of retroviruses. Most (95.8%) of the reactive samples were from women 20–29 years old. Two of five sera from individuals <20 years old reacted for HIV antibodies while one serum from a 40 year old woman was reactive for HTLV-I antibodies Of the 71 reactive sera, 29 (8%) had antibodies to HIV (HIV-1= 14, HIV-2 = 9, HIV-1/2 = 6) and 42 samples (11.5%) showed antibodles to HTLV (HTLV-I = 20, HTLV-II = 14, HTLV-I/II = 8). Seven of 71seroposilive samples (9.8%) reacted for both HIV and HTLV antibodies in various combinations, including one serum that showed antibody reactivities to all four retroviruses (i.e. HIV-1, HIV-2, HTLV-I and HTLV-II). Conclusions. The high prevalence of antibodies to subtypes of the two entirely distinct retrovirus groups in young women has important implications for defining epidemiological patterns of diseases associated with co-infections with two or more retroviruses.</description><identifier>ISSN: 0300-5771</identifier><identifier>EISSN: 1464-3685</identifier><identifier>DOI: 10.1093/ije/24.1.198</identifier><identifier>PMID: 7797344</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Adolescent ; Adult ; AIDS/HIV ; Antibodies, Viral - analysis ; Blotting, Western ; Cross Reactions ; Data Interpretation, Statistical ; Female ; HIV Seropositivity - epidemiology ; HIV Seroprevalence ; HIV-1 - immunology ; HIV-2 - immunology ; HTLV-I Infections - epidemiology ; HTLV-II Infections - epidemiology ; Human T-lymphotropic virus 1 - immunology ; Human T-lymphotropic virus 2 - immunology ; Humans ; Immunoenzyme Techniques ; Nigeria - epidemiology ; Population ; Pregnancy ; Pregnancy Complications, Infectious</subject><ispartof>International journal of epidemiology, 1995-02, Vol.24 (1), p.198-203</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c239t-fbddb05ac33304a6ee362d3592f163a12dbf982bd48859f997ab6913f06264bc3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7797344$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>OLALEYE, DAVID O</creatorcontrib><creatorcontrib>EKWEOZOR, COMFORT C</creatorcontrib><creatorcontrib>SHENG, ZHIJUAN</creatorcontrib><creatorcontrib>RASHEED, SURAIYA</creatorcontrib><title>Evidence of Serological Cross-Reactivities with Human Immunodeficiency Virus Types 1 and 2 and Human T-Lymphotropic Virus Types I and II in Sera of Pregnant Women in Ibadan, Nigeria</title><title>International journal of epidemiology</title><addtitle>Int J Epidemiol</addtitle><description>Background. Our previous studies have indicated that the human immunodeficiency virus (HIV) and human T-Iymphotropic virus (HTLV) groups of retroviruses are endemic among various populations in Nigeria These viruses are antigenically distinct and antibodies to HIV and HTLV do not cross-react, so we studied the prevalence of HIV-1, HIV-2, HTLV-I and HTLV-II antibodies in sera of pregnant women attending an antenatal clinic in Ibadan, Nigena. Methods. In all, 364 sera were screened using three different enzyme immunoassays, Including those that distinguished HIV-1 antibodies from HIV-2, and HTLV-I antibodies from HTLV-II. All repeatedly reactive sera were confirmed by Western blots and synthetic peptide assays for the respective viruses. Results. Overall, 71 sera (19.5%) had antibodies to HIV, HTLV or both groups of retroviruses. Most (95.8%) of the reactive samples were from women 20–29 years old. Two of five sera from individuals <20 years old reacted for HIV antibodies while one serum from a 40 year old woman was reactive for HTLV-I antibodies Of the 71 reactive sera, 29 (8%) had antibodies to HIV (HIV-1= 14, HIV-2 = 9, HIV-1/2 = 6) and 42 samples (11.5%) showed antibodles to HTLV (HTLV-I = 20, HTLV-II = 14, HTLV-I/II = 8). Seven of 71seroposilive samples (9.8%) reacted for both HIV and HTLV antibodies in various combinations, including one serum that showed antibody reactivities to all four retroviruses (i.e. HIV-1, HIV-2, HTLV-I and HTLV-II). Conclusions. The high prevalence of antibodies to subtypes of the two entirely distinct retrovirus groups in young women has important implications for defining epidemiological patterns of diseases associated with co-infections with two or more retroviruses.</description><subject>Adolescent</subject><subject>Adult</subject><subject>AIDS/HIV</subject><subject>Antibodies, Viral - analysis</subject><subject>Blotting, Western</subject><subject>Cross Reactions</subject><subject>Data Interpretation, Statistical</subject><subject>Female</subject><subject>HIV Seropositivity - epidemiology</subject><subject>HIV Seroprevalence</subject><subject>HIV-1 - immunology</subject><subject>HIV-2 - immunology</subject><subject>HTLV-I Infections - epidemiology</subject><subject>HTLV-II Infections - epidemiology</subject><subject>Human T-lymphotropic virus 1 - immunology</subject><subject>Human T-lymphotropic virus 2 - immunology</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Nigeria - epidemiology</subject><subject>Population</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Infectious</subject><issn>0300-5771</issn><issn>1464-3685</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUtv1DAUhS0EKkNhxxbJK1bN1K_Y8RJGbSfSCFAZHmJjObEzdUnsYCeF-WH9f006o0ps7l2c7z50DgBvMVpiJOm5u7XnhC3xEsviGVhgxllGeZE_BwtEEcpyIfBL8CqlW4QwY0yegBMhpKCMLcD9xZ0z1tcWhgZ-tTG0Yedq3cJVDCll11bXg7tzg7MJ_nXDDVyPnfaw7LrRB2MbV7tpeg-_uzgmuN33E4eh9gaSx3rAt9lm3_U3YYihd_V_cPmIlSV0fr6v5z--RLvz2g_wR-isn5Wy0kb7M_jJ7Wx0-jV40eg22TfHfgq-XV5sV-ts8_mqXH3YZDWhcsiaypgK5bqmlCKmubWUE0NzSRrMqcbEVI0sSGVYUeSykVLoiktMG8QJZ1VNT8H7w94-hj-jTYPqXKpt22pvw5iUEJPRjNAJPDuA9WxbtI3qo-t03CuM1JySmlJShCmsppQm_N1x71h11jzBx1gmPTvoLg3235Os42_FBRW5Wv_8pehHec2vcqIu6QOaUJ3t</recordid><startdate>199502</startdate><enddate>199502</enddate><creator>OLALEYE, DAVID O</creator><creator>EKWEOZOR, COMFORT C</creator><creator>SHENG, ZHIJUAN</creator><creator>RASHEED, SURAIYA</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199502</creationdate><title>Evidence of Serological Cross-Reactivities with Human Immunodeficiency Virus Types 1 and 2 and Human T-Lymphotropic Virus Types I and II in Sera of Pregnant Women in Ibadan, Nigeria</title><author>OLALEYE, DAVID O ; EKWEOZOR, COMFORT C ; SHENG, ZHIJUAN ; RASHEED, SURAIYA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c239t-fbddb05ac33304a6ee362d3592f163a12dbf982bd48859f997ab6913f06264bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>AIDS/HIV</topic><topic>Antibodies, Viral - analysis</topic><topic>Blotting, Western</topic><topic>Cross Reactions</topic><topic>Data Interpretation, Statistical</topic><topic>Female</topic><topic>HIV Seropositivity - epidemiology</topic><topic>HIV Seroprevalence</topic><topic>HIV-1 - immunology</topic><topic>HIV-2 - immunology</topic><topic>HTLV-I Infections - epidemiology</topic><topic>HTLV-II Infections - epidemiology</topic><topic>Human T-lymphotropic virus 1 - immunology</topic><topic>Human T-lymphotropic virus 2 - immunology</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Nigeria - epidemiology</topic><topic>Population</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Infectious</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>OLALEYE, DAVID O</creatorcontrib><creatorcontrib>EKWEOZOR, COMFORT C</creatorcontrib><creatorcontrib>SHENG, ZHIJUAN</creatorcontrib><creatorcontrib>RASHEED, SURAIYA</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>OLALEYE, DAVID O</au><au>EKWEOZOR, COMFORT C</au><au>SHENG, ZHIJUAN</au><au>RASHEED, SURAIYA</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evidence of Serological Cross-Reactivities with Human Immunodeficiency Virus Types 1 and 2 and Human T-Lymphotropic Virus Types I and II in Sera of Pregnant Women in Ibadan, Nigeria</atitle><jtitle>International journal of epidemiology</jtitle><addtitle>Int J Epidemiol</addtitle><date>1995-02</date><risdate>1995</risdate><volume>24</volume><issue>1</issue><spage>198</spage><epage>203</epage><pages>198-203</pages><issn>0300-5771</issn><eissn>1464-3685</eissn><abstract>Background. Our previous studies have indicated that the human immunodeficiency virus (HIV) and human T-Iymphotropic virus (HTLV) groups of retroviruses are endemic among various populations in Nigeria These viruses are antigenically distinct and antibodies to HIV and HTLV do not cross-react, so we studied the prevalence of HIV-1, HIV-2, HTLV-I and HTLV-II antibodies in sera of pregnant women attending an antenatal clinic in Ibadan, Nigena. Methods. In all, 364 sera were screened using three different enzyme immunoassays, Including those that distinguished HIV-1 antibodies from HIV-2, and HTLV-I antibodies from HTLV-II. All repeatedly reactive sera were confirmed by Western blots and synthetic peptide assays for the respective viruses. Results. Overall, 71 sera (19.5%) had antibodies to HIV, HTLV or both groups of retroviruses. Most (95.8%) of the reactive samples were from women 20–29 years old. Two of five sera from individuals <20 years old reacted for HIV antibodies while one serum from a 40 year old woman was reactive for HTLV-I antibodies Of the 71 reactive sera, 29 (8%) had antibodies to HIV (HIV-1= 14, HIV-2 = 9, HIV-1/2 = 6) and 42 samples (11.5%) showed antibodles to HTLV (HTLV-I = 20, HTLV-II = 14, HTLV-I/II = 8). Seven of 71seroposilive samples (9.8%) reacted for both HIV and HTLV antibodies in various combinations, including one serum that showed antibody reactivities to all four retroviruses (i.e. HIV-1, HIV-2, HTLV-I and HTLV-II). Conclusions. The high prevalence of antibodies to subtypes of the two entirely distinct retrovirus groups in young women has important implications for defining epidemiological patterns of diseases associated with co-infections with two or more retroviruses.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>7797344</pmid><doi>10.1093/ije/24.1.198</doi><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Adult AIDS/HIV Antibodies, Viral - analysis Blotting, Western Cross Reactions Data Interpretation, Statistical Female HIV Seropositivity - epidemiology HIV Seroprevalence HIV-1 - immunology HIV-2 - immunology HTLV-I Infections - epidemiology HTLV-II Infections - epidemiology Human T-lymphotropic virus 1 - immunology Human T-lymphotropic virus 2 - immunology Humans Immunoenzyme Techniques Nigeria - epidemiology Population Pregnancy Pregnancy Complications, Infectious |
| title | Evidence of Serological Cross-Reactivities with Human Immunodeficiency Virus Types 1 and 2 and Human T-Lymphotropic Virus Types I and II in Sera of Pregnant Women in Ibadan, Nigeria |
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