Effect of Combined Clofazimine and Ansamycin Therapy on Mycobacterium avium—Mycobacterium intracellulare Bacteremia in Patients with AIDS
Mycobacterium avium-Mycobacterium intracellulare (MAI) is a frequent opportunistic pathogen in patients with AIDS and occurs in 40% of patients with AIDS who are autopsied at the National Institutes of Health (NIH). MAI has been found in virtually all organs, including bone marrow, lymph node, lung,...
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| Veröffentlicht in: | The Journal of infectious diseases 1987-01, Vol.155 (1), p.127-129 |
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| container_title | The Journal of infectious diseases |
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| creator | Masur, Henry Tuazon, Carmelita Gill, Vee Grimes, George Baird, Barbara Fauci, Anthony S. Lane, H. Clifford |
| description | Mycobacterium avium-Mycobacterium intracellulare (MAI) is a frequent opportunistic pathogen in patients with AIDS and occurs in 40% of patients with AIDS who are autopsied at the National Institutes of Health (NIH). MAI has been found in virtually all organs, including bone marrow, lymph node, lung, liver, spleen bowel, skin, kidney, and brain. The purpose of this study was to examine the effect of drug combinations that include both clofazimine and ansamycin on one objective measurement of MAI infection - a positive culture of blood - to provide a preliminary insight into the use of such regimens for treating this infection. |
| doi_str_mv | 10.1093/infdis/155.1.127 |
| format | Article |
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The purpose of this study was to examine the effect of drug combinations that include both clofazimine and ansamycin on one objective measurement of MAI infection - a positive culture of blood - to provide a preliminary insight into the use of such regimens for treating this infection.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/155.1.127</identifier><identifier>PMID: 3794396</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject><![CDATA[Acquired Immunodeficiency Syndrome - complications ; AIDS ; AIDS/HIV ; Amikacin - administration & dosage ; Anti-Bacterial Agents - administration & dosage ; Anti-Bacterial Agents - therapeutic use ; Antibacterial agents ; Antibiotics. Antiinfectious agents. 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Drug treatments ; Sepsis - drug therapy ; Sepsis - etiology]]></subject><ispartof>The Journal of infectious diseases, 1987-01, Vol.155 (1), p.127-129</ispartof><rights>Copyright 1987 University of Chicago</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-10b54e2a450f995e15833735802b67cdfc543c27fbecbfec868d8d1cc9703d653</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30105730$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30105730$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,4024,27923,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8332715$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3794396$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Masur, Henry</creatorcontrib><creatorcontrib>Tuazon, Carmelita</creatorcontrib><creatorcontrib>Gill, Vee</creatorcontrib><creatorcontrib>Grimes, George</creatorcontrib><creatorcontrib>Baird, Barbara</creatorcontrib><creatorcontrib>Fauci, Anthony S.</creatorcontrib><creatorcontrib>Lane, H. Clifford</creatorcontrib><title>Effect of Combined Clofazimine and Ansamycin Therapy on Mycobacterium avium—Mycobacterium intracellulare Bacteremia in Patients with AIDS</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Mycobacterium avium-Mycobacterium intracellulare (MAI) is a frequent opportunistic pathogen in patients with AIDS and occurs in 40% of patients with AIDS who are autopsied at the National Institutes of Health (NIH). MAI has been found in virtually all organs, including bone marrow, lymph node, lung, liver, spleen bowel, skin, kidney, and brain. The purpose of this study was to examine the effect of drug combinations that include both clofazimine and ansamycin on one objective measurement of MAI infection - a positive culture of blood - to provide a preliminary insight into the use of such regimens for treating this infection.</description><subject>Acquired Immunodeficiency Syndrome - complications</subject><subject>AIDS</subject><subject>AIDS/HIV</subject><subject>Amikacin - administration & dosage</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Bacteremia</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Ciprofloxacin - administration & dosage</subject><subject>Clofazimine - administration & dosage</subject><subject>Clofazimine - therapeutic use</subject><subject>Concise Laboratory and Clinical Communications</subject><subject>Cycloserine - administration & dosage</subject><subject>Dosage</subject><subject>Drug Therapy, Combination</subject><subject>human immunodeficiency virus</subject><subject>Humans</subject><subject>Infections</subject><subject>Isoniazid - administration & dosage</subject><subject>Lactams, Macrocyclic</subject><subject>Lymph nodes</subject><subject>Macrocyclic lactams</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Mycobacterium</subject><subject>Mycobacterium avium</subject><subject>Mycobacterium avium complex</subject><subject>Mycobacterium Infections - drug therapy</subject><subject>Mycobacterium Infections, Nontuberculous - drug therapy</subject><subject>Mycobacterium Infections, Nontuberculous - etiology</subject><subject>Mycobacterium intracellulare</subject><subject>Pharmacology. Drug treatments</subject><subject>Sepsis - drug therapy</subject><subject>Sepsis - etiology</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkTtvFDEUhS1EFDaBngbJBaKbjT1-zZTLkpe0EaAsEqKxPB5bcZjxbGwPZKno0-YX8kvwsksiKhpf2d-5R773APASoylGNTly3rYuHmHGpniKS_EETDAjouAck6dgglBZFriq62fgIMZrhBAlXOyDfSJqSmo-AXfH1hqd4GDhfOgb500L591g1Q_X5wtUvoUzH1W_1s7D5ZUJarWGg4cXaz00SicT3NhD9S2fv37e__vqfApKm64bOxUMfPsHmN6pTOAHlZzxKcLvLl3B2fm7y-dgz6oumhe7egg-nRwv52fF4v3p-Xy2KDTFNBUYNYyaUlGGbF0zg1lFiCCsQmXDhW6tZpToUtjG6CYPV_GqrVqsdS0QaTkjh-DN1ncVhpvRxCR7FzffVN4MY5RCEM43C_qfEFPOOMNlFqKtUIchxmCsXAXXq7CWGMlNUHIblMxBSSxzULnl1c57bHrTPjTsksn89Y6rqFVng_I6G_yV5ZFLgdmjzXVMQ3h0QRgxQVDmxZa7mMztA1fhq-SCCCbPPn-Ri4-X4qQ6pXJJfgMviriV</recordid><startdate>198701</startdate><enddate>198701</enddate><creator>Masur, Henry</creator><creator>Tuazon, Carmelita</creator><creator>Gill, Vee</creator><creator>Grimes, George</creator><creator>Baird, Barbara</creator><creator>Fauci, Anthony S.</creator><creator>Lane, H. Clifford</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>198701</creationdate><title>Effect of Combined Clofazimine and Ansamycin Therapy on Mycobacterium avium—Mycobacterium intracellulare Bacteremia in Patients with AIDS</title><author>Masur, Henry ; Tuazon, Carmelita ; Gill, Vee ; Grimes, George ; Baird, Barbara ; Fauci, Anthony S. ; Lane, H. Clifford</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-10b54e2a450f995e15833735802b67cdfc543c27fbecbfec868d8d1cc9703d653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Acquired Immunodeficiency Syndrome - complications</topic><topic>AIDS</topic><topic>AIDS/HIV</topic><topic>Amikacin - administration & dosage</topic><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Bacteremia</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Ciprofloxacin - administration & dosage</topic><topic>Clofazimine - administration & dosage</topic><topic>Clofazimine - therapeutic use</topic><topic>Concise Laboratory and Clinical Communications</topic><topic>Cycloserine - administration & dosage</topic><topic>Dosage</topic><topic>Drug Therapy, Combination</topic><topic>human immunodeficiency virus</topic><topic>Humans</topic><topic>Infections</topic><topic>Isoniazid - administration & dosage</topic><topic>Lactams, Macrocyclic</topic><topic>Lymph nodes</topic><topic>Macrocyclic lactams</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Mycobacterium</topic><topic>Mycobacterium avium</topic><topic>Mycobacterium avium complex</topic><topic>Mycobacterium Infections - drug therapy</topic><topic>Mycobacterium Infections, Nontuberculous - drug therapy</topic><topic>Mycobacterium Infections, Nontuberculous - etiology</topic><topic>Mycobacterium intracellulare</topic><topic>Pharmacology. Drug treatments</topic><topic>Sepsis - drug therapy</topic><topic>Sepsis - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Masur, Henry</creatorcontrib><creatorcontrib>Tuazon, Carmelita</creatorcontrib><creatorcontrib>Gill, Vee</creatorcontrib><creatorcontrib>Grimes, George</creatorcontrib><creatorcontrib>Baird, Barbara</creatorcontrib><creatorcontrib>Fauci, Anthony S.</creatorcontrib><creatorcontrib>Lane, H. 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Clifford</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Combined Clofazimine and Ansamycin Therapy on Mycobacterium avium—Mycobacterium intracellulare Bacteremia in Patients with AIDS</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1987-01</date><risdate>1987</risdate><volume>155</volume><issue>1</issue><spage>127</spage><epage>129</epage><pages>127-129</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Mycobacterium avium-Mycobacterium intracellulare (MAI) is a frequent opportunistic pathogen in patients with AIDS and occurs in 40% of patients with AIDS who are autopsied at the National Institutes of Health (NIH). MAI has been found in virtually all organs, including bone marrow, lymph node, lung, liver, spleen bowel, skin, kidney, and brain. 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| fulltext | fulltext |
| identifier | ISSN: 0022-1899 |
| ispartof | The Journal of infectious diseases, 1987-01, Vol.155 (1), p.127-129 |
| issn | 0022-1899 1537-6613 |
| language | eng |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing |
| subjects | Acquired Immunodeficiency Syndrome - complications AIDS AIDS/HIV Amikacin - administration & dosage Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - therapeutic use Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Bacteremia Biological and medical sciences Blood Ciprofloxacin - administration & dosage Clofazimine - administration & dosage Clofazimine - therapeutic use Concise Laboratory and Clinical Communications Cycloserine - administration & dosage Dosage Drug Therapy, Combination human immunodeficiency virus Humans Infections Isoniazid - administration & dosage Lactams, Macrocyclic Lymph nodes Macrocyclic lactams Medical sciences Microbiology Mycobacterium Mycobacterium avium Mycobacterium avium complex Mycobacterium Infections - drug therapy Mycobacterium Infections, Nontuberculous - drug therapy Mycobacterium Infections, Nontuberculous - etiology Mycobacterium intracellulare Pharmacology. Drug treatments Sepsis - drug therapy Sepsis - etiology |
| title | Effect of Combined Clofazimine and Ansamycin Therapy on Mycobacterium avium—Mycobacterium intracellulare Bacteremia in Patients with AIDS |
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