Antigen receptor-triggered secretion of a trypsin-type esterase from cytotoxic T lymphocytes

Exocytosis of cytolysin-containing granules from cytotoxic T lymphocytes (CTL) was studied with the use of granule enzyme (BLT esterase) as a convenient biochemical marker. Using cloned CTL, we demonstrate here that BLT esterase secretion into the supernatant is specifically triggered by antigen-bea...

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Veröffentlicht in:	The Journal of immunology (1950) 1987-01, Vol.138 (2), p.566-569
Hauptverfasser:	Takayama, H, Trenn, G, Humphrey, W, Jr, Bluestone, JA, Henkart, PA, Sitkovsky, MV
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal Biological and medical sciences Cell Line Cytoplasmic Granules - enzymology Cytoplasmic Granules - physiology Cytotoxic reactions (adcc reaction, cell-mediated lympholysis, complement-dependent cytotoxicity and others) Cytotoxicity, Immunologic Esterases - secretion Exocytosis Fundamental and applied biological sciences. Psychology Fundamental immunology Immunobiology Immunological reactions in vitro Mice Receptors, Antigen, T-Cell - physiology Solubility T-Lymphocytes, Cytotoxic - enzymology
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