Neutral Amino Acid Transport Characterization of Isolated Luminal and Abluminal Membranes of the Blood-Brain Barrier (∗)

The neutral amino acid carrier composition of luminal and abluminal membranes of the blood-brain barrier has been studied using isolated membrane vesicles. Phenylalanine was carried almost exclusively by a high affinity (Km = 10 ± 2 μM), Na+-independent amino acid transport system, presumably L1 sys...

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Veröffentlicht in:	The Journal of biological chemistry 1995-06, Vol.270 (25), p.14913-14918
Hauptverfasser:	del Pino, Manuel M. Sánchez, Peterson, Darryl R., Hawkins, Richard A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine - metabolism Amino Acids - metabolism Amino Acids - pharmacology Amino Acids, Cyclic Animals beta-Alanine - analogs & derivatives beta-Alanine - metabolism Biological Transport - drug effects Blood-Brain Barrier Cattle Cell Fractionation Cell Membrane - metabolism Cell Membrane - ultrastructure Centrifugation, Zonal Endothelium, Vascular - metabolism Endothelium, Vascular - ultrastructure Ficoll Glutamine - metabolism Kinetics Leucine - metabolism Microcirculation - metabolism Microcirculation - ultrastructure Phenylalanine - metabolism Sodium - metabolism Tryptophan - metabolism
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