Expression of a Delta homologue in prospective neurons in the chick
THE product of the Delta gene, acting as ligand, and that of the Notch gene, acting as receptor, are key components in a lateral-inhibition signalling pathway that regulates the detailed patterning of many different tissues in Drosophila 1–8 . During neurogenesis in particular, neural precursors, by...
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| Veröffentlicht in: | Nature (London) 1995-06, Vol.375 (6534), p.787-790 |
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| creator | Henrique, Domingos Adam, Julie Myat, Anna Chitnis, Ajay Lewis, Julian Ish-Horowicz, David |
| description | THE product of the
Delta
gene, acting as ligand, and that of the
Notch
gene, acting as receptor, are key components in a lateral-inhibition signalling pathway that regulates the detailed patterning of many different tissues in
Drosophila
1–8
. During neurogenesis in particular, neural precursors, by expressing
Delta
, inhibit neighbouring
Notch
-expressing cells from becoming committed to a neural fate
5,9,10
. Vertebrates are known to have several Notch genes
11–14
, but their functions are unclear and their ligands hitherto unidentified. Here we identify and describe a chick
Delta
homologue,
C-Delta-1
. We show that
C-Delta-1
is expressed in prospective neurons during neurogenesis, as new cells are being born and their fates decided. Our data from the chick, combined with parallel evidence from
Xenopus
15
, suggest that both the Delta/ Notch signalling mechanism and its role in neurogenesis have been conserved in vertebrates. |
| doi_str_mv | 10.1038/375787a0 |
| format | Article |
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Delta
gene, acting as ligand, and that of the
Notch
gene, acting as receptor, are key components in a lateral-inhibition signalling pathway that regulates the detailed patterning of many different tissues in
Drosophila
1–8
. During neurogenesis in particular, neural precursors, by expressing
Delta
, inhibit neighbouring
Notch
-expressing cells from becoming committed to a neural fate
5,9,10
. Vertebrates are known to have several Notch genes
11–14
, but their functions are unclear and their ligands hitherto unidentified. Here we identify and describe a chick
Delta
homologue,
C-Delta-1
. We show that
C-Delta-1
is expressed in prospective neurons during neurogenesis, as new cells are being born and their fates decided. Our data from the chick, combined with parallel evidence from
Xenopus
15
, suggest that both the Delta/ Notch signalling mechanism and its role in neurogenesis have been conserved in vertebrates.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/375787a0</identifier><identifier>PMID: 7596411</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Amino Acid Sequence ; Animals ; Base Sequence ; Biological and medical sciences ; Cell Differentiation ; Cellular biology ; Central Nervous System - cytology ; Central Nervous System - embryology ; Central Nervous System - metabolism ; Chick Embryo ; Classical genetics, quantitative genetics, hybrids ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation, Developmental ; Genetics of eukaryotes. Biological and molecular evolution ; Humanities and Social Sciences ; Intracellular Signaling Peptides and Proteins ; Invertebrata ; letter ; Membrane Proteins - biosynthesis ; Membrane Proteins - chemistry ; Membrane Proteins - genetics ; Molecular Sequence Data ; multidisciplinary ; Neurons ; Neurons - cytology ; Neurons - metabolism ; Poultry ; Receptors, Cell Surface - genetics ; Receptors, Notch ; Science ; Science (multidisciplinary) ; Vertebrates ; Xenopus</subject><ispartof>Nature (London), 1995-06, Vol.375 (6534), p.787-790</ispartof><rights>Springer Nature Limited 1995</rights><rights>1995 INIST-CNRS</rights><rights>Copyright Macmillan Journals Ltd. Jun 29, 1995</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4510-949acd0130936c324f73b118f02714b0f2ff36eacf180d87bae9dce73fe962eb3</citedby><cites>FETCH-LOGICAL-c4510-949acd0130936c324f73b118f02714b0f2ff36eacf180d87bae9dce73fe962eb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/375787a0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/375787a0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3564012$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7596411$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Henrique, Domingos</creatorcontrib><creatorcontrib>Adam, Julie</creatorcontrib><creatorcontrib>Myat, Anna</creatorcontrib><creatorcontrib>Chitnis, Ajay</creatorcontrib><creatorcontrib>Lewis, Julian</creatorcontrib><creatorcontrib>Ish-Horowicz, David</creatorcontrib><title>Expression of a Delta homologue in prospective neurons in the chick</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>THE product of the
Delta
gene, acting as ligand, and that of the
Notch
gene, acting as receptor, are key components in a lateral-inhibition signalling pathway that regulates the detailed patterning of many different tissues in
Drosophila
1–8
. During neurogenesis in particular, neural precursors, by expressing
Delta
, inhibit neighbouring
Notch
-expressing cells from becoming committed to a neural fate
5,9,10
. Vertebrates are known to have several Notch genes
11–14
, but their functions are unclear and their ligands hitherto unidentified. Here we identify and describe a chick
Delta
homologue,
C-Delta-1
. We show that
C-Delta-1
is expressed in prospective neurons during neurogenesis, as new cells are being born and their fates decided. Our data from the chick, combined with parallel evidence from
Xenopus
15
, suggest that both the Delta/ Notch signalling mechanism and its role in neurogenesis have been conserved in vertebrates.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Cell Differentiation</subject><subject>Cellular biology</subject><subject>Central Nervous System - cytology</subject><subject>Central Nervous System - embryology</subject><subject>Central Nervous System - metabolism</subject><subject>Chick Embryo</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Humanities and Social Sciences</subject><subject>Intracellular Signaling Peptides and Proteins</subject><subject>Invertebrata</subject><subject>letter</subject><subject>Membrane Proteins - biosynthesis</subject><subject>Membrane Proteins - chemistry</subject><subject>Membrane Proteins - genetics</subject><subject>Molecular Sequence Data</subject><subject>multidisciplinary</subject><subject>Neurons</subject><subject>Neurons - cytology</subject><subject>Neurons - metabolism</subject><subject>Poultry</subject><subject>Receptors, Cell Surface - genetics</subject><subject>Receptors, Notch</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Vertebrates</subject><subject>Xenopus</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkV1rFDEUhoModa0F_4AwSNH2YvScJJOPy7LWWih4o9dDJnvSnTo7WZOd0v57s-y2QgW9OnDeh_d8vIy9QfiIIMwnoRtttINnbIZSq1oqo5-zGQA3NRihXrJXOd8AQINaHrAD3VglEWdsfn63TpRzH8cqhspVn2nYuGoZV3GI1xNV_VitU8xr8pv-lqqRphTHvG1vllT5Ze9_vmYvghsyHe3rIfvx5fz7_Gt99e3icn52VXvZINRWWucXgAKsUF5wGbToEE0ArlF2EHgIQpHzAQ0sjO4c2YUnLQJZxakTh-z9zrcs9GuivGlXffY0DG6kOOVWa6E4V6aAH_4NStEY5Mb-1xKVttqiKuC7J-BNnNJYzm05SKmxUbxAJzvIl4_lRKFdp37l0n2L0G5zah9yKujbvd_UrWjxCO6DKfrxXnfZuyEkN_o-P2KiURJwO_F0h-WijNeU_qz118jfNC6kog</recordid><startdate>19950629</startdate><enddate>19950629</enddate><creator>Henrique, Domingos</creator><creator>Adam, Julie</creator><creator>Myat, Anna</creator><creator>Chitnis, Ajay</creator><creator>Lewis, Julian</creator><creator>Ish-Horowicz, David</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7ST</scope><scope>7T5</scope><scope>7TG</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>S0X</scope><scope>SOI</scope><scope>7SC</scope><scope>7SP</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>F28</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>7X8</scope></search><sort><creationdate>19950629</creationdate><title>Expression of a Delta homologue in prospective neurons in the chick</title><author>Henrique, Domingos ; Adam, Julie ; Myat, Anna ; Chitnis, Ajay ; Lewis, Julian ; Ish-Horowicz, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4510-949acd0130936c324f73b118f02714b0f2ff36eacf180d87bae9dce73fe962eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Cell Differentiation</topic><topic>Cellular biology</topic><topic>Central Nervous System - cytology</topic><topic>Central Nervous System - embryology</topic><topic>Central Nervous System - metabolism</topic><topic>Chick Embryo</topic><topic>Classical genetics, quantitative genetics, hybrids</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Humanities and Social Sciences</topic><topic>Intracellular Signaling Peptides and Proteins</topic><topic>Invertebrata</topic><topic>letter</topic><topic>Membrane Proteins - biosynthesis</topic><topic>Membrane Proteins - chemistry</topic><topic>Membrane Proteins - genetics</topic><topic>Molecular Sequence Data</topic><topic>multidisciplinary</topic><topic>Neurons</topic><topic>Neurons - cytology</topic><topic>Neurons - metabolism</topic><topic>Poultry</topic><topic>Receptors, Cell Surface - genetics</topic><topic>Receptors, Notch</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Vertebrates</topic><topic>Xenopus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Henrique, Domingos</creatorcontrib><creatorcontrib>Adam, Julie</creatorcontrib><creatorcontrib>Myat, Anna</creatorcontrib><creatorcontrib>Chitnis, Ajay</creatorcontrib><creatorcontrib>Lewis, Julian</creatorcontrib><creatorcontrib>Ish-Horowicz, David</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Henrique, Domingos</au><au>Adam, Julie</au><au>Myat, Anna</au><au>Chitnis, Ajay</au><au>Lewis, Julian</au><au>Ish-Horowicz, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of a Delta homologue in prospective neurons in the chick</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1995-06-29</date><risdate>1995</risdate><volume>375</volume><issue>6534</issue><spage>787</spage><epage>790</epage><pages>787-790</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><coden>NATUAS</coden><abstract>THE product of the
Delta
gene, acting as ligand, and that of the
Notch
gene, acting as receptor, are key components in a lateral-inhibition signalling pathway that regulates the detailed patterning of many different tissues in
Drosophila
1–8
. During neurogenesis in particular, neural precursors, by expressing
Delta
, inhibit neighbouring
Notch
-expressing cells from becoming committed to a neural fate
5,9,10
. Vertebrates are known to have several Notch genes
11–14
, but their functions are unclear and their ligands hitherto unidentified. Here we identify and describe a chick
Delta
homologue,
C-Delta-1
. We show that
C-Delta-1
is expressed in prospective neurons during neurogenesis, as new cells are being born and their fates decided. Our data from the chick, combined with parallel evidence from
Xenopus
15
, suggest that both the Delta/ Notch signalling mechanism and its role in neurogenesis have been conserved in vertebrates.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>7596411</pmid><doi>10.1038/375787a0</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1995-06, Vol.375 (6534), p.787-790 |
| issn | 0028-0836 1476-4687 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77362268 |
| source | MEDLINE; Nature; SpringerLink Journals - AutoHoldings |
| subjects | Amino Acid Sequence Animals Base Sequence Biological and medical sciences Cell Differentiation Cellular biology Central Nervous System - cytology Central Nervous System - embryology Central Nervous System - metabolism Chick Embryo Classical genetics, quantitative genetics, hybrids Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Developmental Genetics of eukaryotes. Biological and molecular evolution Humanities and Social Sciences Intracellular Signaling Peptides and Proteins Invertebrata letter Membrane Proteins - biosynthesis Membrane Proteins - chemistry Membrane Proteins - genetics Molecular Sequence Data multidisciplinary Neurons Neurons - cytology Neurons - metabolism Poultry Receptors, Cell Surface - genetics Receptors, Notch Science Science (multidisciplinary) Vertebrates Xenopus |
| title | Expression of a Delta homologue in prospective neurons in the chick |
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