An antibody against the exosite of the cloned thrombin receptor inhibits experimental arterial thrombosis in the African green monkey

Thrombin inhibitors have been shown to be efficacious in animal models of thrombosis and in initial human clinical trials. It is unknown if their efficacy is due to their prevention of thrombin-mediated fibrin formation or to an inhibitory effect on thrombin-stimulated platelet activation. Appropria...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 1995-06, Vol.91 (12), p.2961-2971
Hauptverfasser:	COOK, J. J, SITKO, G. R, BEDNAR, B, CONDRA, C, MELLOTT, M. J, DONG-MEI FENG, NUTT, R. F, SHAFER, J. A, GOULD, R. J, CONNOLLY, T. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies - therapeutic use Antibody Formation Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Cercopithecus aethiops Medical sciences Pharmacology. Drug treatments Platelet Aggregation - drug effects Receptors, Thrombin - chemistry Receptors, Thrombin - genetics Receptors, Thrombin - immunology Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - immunology Thrombosis - drug therapy
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