In Vivo Intestinal Uptake of Immunoreactive Bovine Albumin in Piglet Enteritis
Summary We examined the uptake of bovine serum albumin (BSA) from the intestine into the circulation of 3‐week‐old piglets infected with transmissible gastroenteritis virus. Transfer of immunoreactive bovine serum albumin (iBSA) from the intestinal lumen into the circulation was enhanced during both...
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| Veröffentlicht in: | Journal of pediatric gastroenterology and nutrition 1987-01, Vol.6 (1), p.135-140 |
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| container_title | Journal of pediatric gastroenterology and nutrition |
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| creator | Keljo, David J. Bloch, Kurt J. Bloch, Margot Arighi, Mimi Hamilton, J. R. |
| description | Summary
We examined the uptake of bovine serum albumin (BSA) from the intestine into the circulation of 3‐week‐old piglets infected with transmissible gastroenteritis virus. Transfer of immunoreactive bovine serum albumin (iBSA) from the intestinal lumen into the circulation was enhanced during both the early invasive phase of this viral enteritis (12‐h postinoculation) and the diarrheal phase (84‐h postinoculation). In some animals, enhanced uptake persisted into the recovery phase, 324 h after inoculation. Gel filtration studies suggested that iBSA had the molecular size characteristic of native BSA; no immunoreactive fragments of BSA were detected. Based on studies of two animal she half‐life of iBSA approximated that of porcine albumin. Further study is required to determine the immunological consequences of the enhanced uptake of protein occurring during viral infection of the intestine. |
| doi_str_mv | 10.1002/j.1536-4801.1987.tb09257.x |
| format | Article |
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We examined the uptake of bovine serum albumin (BSA) from the intestine into the circulation of 3‐week‐old piglets infected with transmissible gastroenteritis virus. Transfer of immunoreactive bovine serum albumin (iBSA) from the intestinal lumen into the circulation was enhanced during both the early invasive phase of this viral enteritis (12‐h postinoculation) and the diarrheal phase (84‐h postinoculation). In some animals, enhanced uptake persisted into the recovery phase, 324 h after inoculation. Gel filtration studies suggested that iBSA had the molecular size characteristic of native BSA; no immunoreactive fragments of BSA were detected. Based on studies of two animal she half‐life of iBSA approximated that of porcine albumin. Further study is required to determine the immunological consequences of the enhanced uptake of protein occurring during viral infection of the intestine.</description><identifier>ISSN: 0277-2116</identifier><identifier>EISSN: 1536-4801</identifier><identifier>DOI: 10.1002/j.1536-4801.1987.tb09257.x</identifier><identifier>PMID: 3794927</identifier><identifier>CODEN: JPGND6</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>Animals ; Biological and medical sciences ; Chromatography, Gel ; Gastroenteritis, Transmissible, of Swine - metabolism ; Gastroenterology. Liver. Pancreas. Abdomen ; Intestinal antigen uptake ; Intestinal Mucosa - metabolism ; Male ; Medical sciences ; Molecular Weight ; Other diseases. Semiology ; Serum Albumin, Bovine - immunology ; Serum Albumin, Bovine - metabolism ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Swine ; Transmissible gastroenteritis virus ; Viral enteritis</subject><ispartof>Journal of pediatric gastroenterology and nutrition, 1987-01, Vol.6 (1), p.135-140</ispartof><rights>1987 by European Society for European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition</rights><rights>Lippincott-Raven Publishers.</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,4025,27927,27928,27929</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8164639$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3794927$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Keljo, David J.</creatorcontrib><creatorcontrib>Bloch, Kurt J.</creatorcontrib><creatorcontrib>Bloch, Margot</creatorcontrib><creatorcontrib>Arighi, Mimi</creatorcontrib><creatorcontrib>Hamilton, J. R.</creatorcontrib><title>In Vivo Intestinal Uptake of Immunoreactive Bovine Albumin in Piglet Enteritis</title><title>Journal of pediatric gastroenterology and nutrition</title><addtitle>J Pediatr Gastroenterol Nutr</addtitle><description>Summary
We examined the uptake of bovine serum albumin (BSA) from the intestine into the circulation of 3‐week‐old piglets infected with transmissible gastroenteritis virus. Transfer of immunoreactive bovine serum albumin (iBSA) from the intestinal lumen into the circulation was enhanced during both the early invasive phase of this viral enteritis (12‐h postinoculation) and the diarrheal phase (84‐h postinoculation). In some animals, enhanced uptake persisted into the recovery phase, 324 h after inoculation. Gel filtration studies suggested that iBSA had the molecular size characteristic of native BSA; no immunoreactive fragments of BSA were detected. Based on studies of two animal she half‐life of iBSA approximated that of porcine albumin. Further study is required to determine the immunological consequences of the enhanced uptake of protein occurring during viral infection of the intestine.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chromatography, Gel</subject><subject>Gastroenteritis, Transmissible, of Swine - metabolism</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Intestinal antigen uptake</subject><subject>Intestinal Mucosa - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Molecular Weight</subject><subject>Other diseases. Semiology</subject><subject>Serum Albumin, Bovine - immunology</subject><subject>Serum Albumin, Bovine - metabolism</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Swine</subject><subject>Transmissible gastroenteritis virus</subject><subject>Viral enteritis</subject><issn>0277-2116</issn><issn>1536-4801</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkUFv3CAUhFHVKt2m_QmVrKrqze4DDJjeklXSbhSlOTS9IoyhYYPtjbE3yb8v1lp7jwTiMDO84QOhLxgKDEC-bwvMKM_LCnCBZSWKsQZJmCie36DVUXqLVkCEyAnG_D36EOMWAETJ4ASdUCFLScQK3Wy67K_f99mmG20cfadDdrcb9YPNepdt2nbq-sFqM_q9zc77ve9sdhbqqfVdltat_xfsmF2k8OBHHz-id06HaD8t5ym6u7z4s_6VX__-uVmfXeeG0Irm0tgGmooZYmurRa2lK7HVDgOhhmNaN4IxKQVxhgspnXOMad5wA-AIkZSeom-He3dD_zil4qr10dgQdGf7KSohKAcJkIw_DkYz9DEO1qnd4Fs9vCgMaoaptmompmZiaoapFpjqOYU_L1OmurXNMbrQS_rXRdfR6OAG3Rkfj7YK85JTmWzlwfbUh8QpPoTpyQ7q3uow3qv0KcCw4Pk8HFIlyNMm8xvXS8wH-_KK3urq9oaeX2IMAtP_cKqiIQ</recordid><startdate>198701</startdate><enddate>198701</enddate><creator>Keljo, David J.</creator><creator>Bloch, Kurt J.</creator><creator>Bloch, Margot</creator><creator>Arighi, Mimi</creator><creator>Hamilton, J. R.</creator><general>Lippincott-Raven Publishers</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198701</creationdate><title>In Vivo Intestinal Uptake of Immunoreactive Bovine Albumin in Piglet Enteritis</title><author>Keljo, David J. ; Bloch, Kurt J. ; Bloch, Margot ; Arighi, Mimi ; Hamilton, J. R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2383-9ced0d85c2ebea7ba9f41eaf1023c613bd7559972fc6799fff55a6d6c00f22933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Chromatography, Gel</topic><topic>Gastroenteritis, Transmissible, of Swine - metabolism</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Intestinal antigen uptake</topic><topic>Intestinal Mucosa - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Molecular Weight</topic><topic>Other diseases. Semiology</topic><topic>Serum Albumin, Bovine - immunology</topic><topic>Serum Albumin, Bovine - metabolism</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Swine</topic><topic>Transmissible gastroenteritis virus</topic><topic>Viral enteritis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Keljo, David J.</creatorcontrib><creatorcontrib>Bloch, Kurt J.</creatorcontrib><creatorcontrib>Bloch, Margot</creatorcontrib><creatorcontrib>Arighi, Mimi</creatorcontrib><creatorcontrib>Hamilton, J. R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Keljo, David J.</au><au>Bloch, Kurt J.</au><au>Bloch, Margot</au><au>Arighi, Mimi</au><au>Hamilton, J. R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In Vivo Intestinal Uptake of Immunoreactive Bovine Albumin in Piglet Enteritis</atitle><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle><addtitle>J Pediatr Gastroenterol Nutr</addtitle><date>1987-01</date><risdate>1987</risdate><volume>6</volume><issue>1</issue><spage>135</spage><epage>140</epage><pages>135-140</pages><issn>0277-2116</issn><eissn>1536-4801</eissn><coden>JPGND6</coden><abstract>Summary
We examined the uptake of bovine serum albumin (BSA) from the intestine into the circulation of 3‐week‐old piglets infected with transmissible gastroenteritis virus. Transfer of immunoreactive bovine serum albumin (iBSA) from the intestinal lumen into the circulation was enhanced during both the early invasive phase of this viral enteritis (12‐h postinoculation) and the diarrheal phase (84‐h postinoculation). In some animals, enhanced uptake persisted into the recovery phase, 324 h after inoculation. Gel filtration studies suggested that iBSA had the molecular size characteristic of native BSA; no immunoreactive fragments of BSA were detected. Based on studies of two animal she half‐life of iBSA approximated that of porcine albumin. Further study is required to determine the immunological consequences of the enhanced uptake of protein occurring during viral infection of the intestine.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>3794927</pmid><doi>10.1002/j.1536-4801.1987.tb09257.x</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0277-2116 |
| ispartof | Journal of pediatric gastroenterology and nutrition, 1987-01, Vol.6 (1), p.135-140 |
| issn | 0277-2116 1536-4801 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Animals Biological and medical sciences Chromatography, Gel Gastroenteritis, Transmissible, of Swine - metabolism Gastroenterology. Liver. Pancreas. Abdomen Intestinal antigen uptake Intestinal Mucosa - metabolism Male Medical sciences Molecular Weight Other diseases. Semiology Serum Albumin, Bovine - immunology Serum Albumin, Bovine - metabolism Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Swine Transmissible gastroenteritis virus Viral enteritis |
| title | In Vivo Intestinal Uptake of Immunoreactive Bovine Albumin in Piglet Enteritis |
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