Interleukin 1 inhibitor masks high interleukin 1 production in acquired immunodeficiency syndrome (AIDS)
Monocyte functions, including interleukin 1 (IL-1) production, have been shown previously to be impaired in acquired immunodeficiency syndrome (AIDS). We have fractionated culture supernatants from unstimulated peripheral blood mononuclear cells (PBMCs) to determine whether the low IL-1 activity in...
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| Veröffentlicht in: | Clinical immunology and immunopathology 1987, Vol.42 (1), p.133-140 |
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| container_end_page | 140 |
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| container_issue | 1 |
| container_start_page | 133 |
| container_title | Clinical immunology and immunopathology |
| container_volume | 42 |
| creator | Berman, Monique A. Sandborg, Christy I. Calabia, Belinda S. Andrews, Brian S. Friou, George J. |
| description | Monocyte functions, including interleukin 1 (IL-1) production, have been shown previously to be impaired in acquired immunodeficiency syndrome (AIDS). We have fractionated culture supernatants from unstimulated peripheral blood mononuclear cells (PBMCs) to determine whether the low IL-1 activity in AIDS was due to the presence of IL-1 inhibitors. The results demonstrate that PBMCs from patients with AIDS produce increased amounts of IL-1 activity compared with those of controls together with marked increases (10- to 20-fold) in the amounts of 50,000–100,000 and 6000–9000 molecular weight (MW) factors which inhibit IL-1 activity. These inhibitors mask IL-1 activity measured in the standard thymocyte proliferation assay for IL-1. The 6000–9000 MW IL-1 inhibitor shows the greatest increase in all AIDS patients (
n = 5) compared with that of controls (
n = 7). This inhibitor may block the IL-1 dependent maturation of T lymphocytes in AIDS and thereby contribute to the immunodeficiency. |
| doi_str_mv | 10.1016/0090-1229(87)90180-2 |
| format | Article |
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n = 5) compared with that of controls (
n = 7). This inhibitor may block the IL-1 dependent maturation of T lymphocytes in AIDS and thereby contribute to the immunodeficiency.</description><subject>Acquired Immunodeficiency Syndrome - immunology</subject><subject>Acquired Immunodeficiency Syndrome - metabolism</subject><subject>Adult</subject><subject>AIDS/HIV</subject><subject>Biological and medical sciences</subject><subject>Cells, Cultured</subject><subject>human immunodeficiency virus</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Interleukin-1 - antagonists & inhibitors</subject><subject>Interleukin-1 - biosynthesis</subject><subject>Lymphokines - biosynthesis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Monocytes - metabolism</subject><issn>0090-1229</issn><issn>1090-2341</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFO3DAQhq2qFWxp34BKOVQVHNKOHW9sXyoh2sJKSBxoz5ZjT1hD4oCdIO3b47CrVU9wsjTzzej3N4QcU_hOgdY_ABSUlDF1IsWpAiqhZO_Igs5lVnH6niz2yCH5mNIdANQcxAE5qLiigrIFWa_CiLHD6d6HghY-rH3jxyEWvUn3qVj723Uu_o88xMFNdvRDyI3C2MfJR3SF7_spDA5bbz0GuynSJrg49FicnK1-3Zx-Ih9a0yX8vHuPyL8_v_-eX5ZX1xer87Or0nIqxlLWyihLbWtbbHJGaaq2ZiAhf8iJZS2cMsDQmIwvQQgmm6YxNZfCCYpGVEfk23Zvzvk4YRp175PFrjMBhylpIaqllIq-CVIuasmAZZBvQRuHlCK2-iH63sSNpqDnS-hZs541ayn0yyX0PPZlt39qenT7oZ363P-665tkTddGE6xPe0wCcMXnmD-3GGZpTx6jTi-C0WXtdtRu8K_neAbuq6Rx</recordid><startdate>1987</startdate><enddate>1987</enddate><creator>Berman, Monique A.</creator><creator>Sandborg, Christy I.</creator><creator>Calabia, Belinda S.</creator><creator>Andrews, Brian S.</creator><creator>Friou, George J.</creator><general>Elsevier Inc</general><general>Academic Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>1987</creationdate><title>Interleukin 1 inhibitor masks high interleukin 1 production in acquired immunodeficiency syndrome (AIDS)</title><author>Berman, Monique A. ; Sandborg, Christy I. ; Calabia, Belinda S. ; Andrews, Brian S. ; Friou, George J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-869a9c1cfcfeb9178a3f62080341d7567d9a02eaac41507728bbba6487d71ea73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Acquired Immunodeficiency Syndrome - immunology</topic><topic>Acquired Immunodeficiency Syndrome - metabolism</topic><topic>Adult</topic><topic>AIDS/HIV</topic><topic>Biological and medical sciences</topic><topic>Cells, Cultured</topic><topic>human immunodeficiency virus</topic><topic>Humans</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Interleukin-1 - antagonists & inhibitors</topic><topic>Interleukin-1 - biosynthesis</topic><topic>Lymphokines - biosynthesis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Monocytes - metabolism</topic><toplevel>online_resources</toplevel><creatorcontrib>Berman, Monique A.</creatorcontrib><creatorcontrib>Sandborg, Christy I.</creatorcontrib><creatorcontrib>Calabia, Belinda S.</creatorcontrib><creatorcontrib>Andrews, Brian S.</creatorcontrib><creatorcontrib>Friou, George J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical immunology and immunopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Berman, Monique A.</au><au>Sandborg, Christy I.</au><au>Calabia, Belinda S.</au><au>Andrews, Brian S.</au><au>Friou, George J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interleukin 1 inhibitor masks high interleukin 1 production in acquired immunodeficiency syndrome (AIDS)</atitle><jtitle>Clinical immunology and immunopathology</jtitle><addtitle>Clin Immunol Immunopathol</addtitle><date>1987</date><risdate>1987</risdate><volume>42</volume><issue>1</issue><spage>133</spage><epage>140</epage><pages>133-140</pages><issn>0090-1229</issn><eissn>1090-2341</eissn><coden>CLIIAT</coden><abstract>Monocyte functions, including interleukin 1 (IL-1) production, have been shown previously to be impaired in acquired immunodeficiency syndrome (AIDS). We have fractionated culture supernatants from unstimulated peripheral blood mononuclear cells (PBMCs) to determine whether the low IL-1 activity in AIDS was due to the presence of IL-1 inhibitors. The results demonstrate that PBMCs from patients with AIDS produce increased amounts of IL-1 activity compared with those of controls together with marked increases (10- to 20-fold) in the amounts of 50,000–100,000 and 6000–9000 molecular weight (MW) factors which inhibit IL-1 activity. These inhibitors mask IL-1 activity measured in the standard thymocyte proliferation assay for IL-1. The 6000–9000 MW IL-1 inhibitor shows the greatest increase in all AIDS patients (
n = 5) compared with that of controls (
n = 7). This inhibitor may block the IL-1 dependent maturation of T lymphocytes in AIDS and thereby contribute to the immunodeficiency.</abstract><cop>San Diego, CA</cop><cop>New York, NY</cop><cop>Boston</cop><pub>Elsevier Inc</pub><pmid>3491712</pmid><doi>10.1016/0090-1229(87)90180-2</doi><tpages>8</tpages></addata></record> |
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| ispartof | Clinical immunology and immunopathology, 1987, Vol.42 (1), p.133-140 |
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| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Acquired Immunodeficiency Syndrome - immunology Acquired Immunodeficiency Syndrome - metabolism Adult AIDS/HIV Biological and medical sciences Cells, Cultured human immunodeficiency virus Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Interleukin-1 - antagonists & inhibitors Interleukin-1 - biosynthesis Lymphokines - biosynthesis Male Medical sciences Middle Aged Monocytes - metabolism |
| title | Interleukin 1 inhibitor masks high interleukin 1 production in acquired immunodeficiency syndrome (AIDS) |
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