In vivo DNA-protein cross-linking by cis- and trans-diamminedichloroplatinum(II)

When Novikoff hepatoma-bearing rats were given injections of a therapeutic dose of cis-diamminedichloroplatinum(II) (cis-DDP) (7 mg/kg), DNA-protein cross-links could be detected by using antisera to dehistonized chromatin, nuclear matrix, or Novikoff hepatoma cytoskeletal preparation. The extent of...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1987, Vol.47 (1), p.201-205
Hauptverfasser:	OLINSKI, R, WEDRYCHOWSKI, A, SCHMIDT, W. N, BRIGGS, R. C, HNILICA, L. S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Cisplatin - pharmacology Cross-Linking Reagents - pharmacology DNA - metabolism DNA Repair General aspects Keratins - metabolism Liver Neoplasms, Experimental - metabolism Male Medical sciences Molecular Weight Pharmacology. Drug treatments Proteins - metabolism Rats Rats, Inbred Strains Stereoisomerism
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