Immunosuppression and intracellular calcium signaling in splenocytes from chicks infected with chicken anemia virus, CL-1 isolate
Hematocrits, histopathology, concanavalin A-induced lymphocyte proliferation, intracellular calcium signaling, and lymphocyte subpopulations were analyzed over a 6-week period in individual chicks inoculated with the CL-1 isolate of chicken anemia virus. Lymphoid depletion/atrophy was present in the...
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| Veröffentlicht in: | Avian diseases 1995, Vol.39 (1), p.135-140 |
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| creator | Bounous, Denise I. Goodwin, Mark A. Brooks, Randolph L. Lamichhane, Chinta M. Campagnoli, Raymond P. Brown, John Snyder, David B. |
| description | Hematocrits, histopathology, concanavalin A-induced lymphocyte proliferation, intracellular calcium signaling, and lymphocyte subpopulations were analyzed over a 6-week period in individual chicks inoculated with the CL-1 isolate of chicken anemia virus. Lymphoid depletion/atrophy was present in the thymus and bone marrow by 11 days postinfection (PI). Anemia was present at 14 days PI. The mean lymphocyte proliferation stimulation index (SI) of the inoculated group was significantly lower than that of the control group at 11 days PI. This response was reversed at 18 days PI, when the SI of the inoculated group was significantly higher than that of the controls; values subsequently returned to baseline. The increase in intracellular calcium levels in CAV-infected chicks and controls paralleled the proliferative response. Percentages of CD3-, CD4-, CD8-, and natural-killer-positive-staining cells decreased significantly at 18 and 25 days PI. The most dramatic decrease occurred in the CD8-positive-staining cell population at 18 and 25 days PI. |
| doi_str_mv | 10.2307/1591992 |
| format | Article |
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Lymphoid depletion/atrophy was present in the thymus and bone marrow by 11 days postinfection (PI). Anemia was present at 14 days PI. The mean lymphocyte proliferation stimulation index (SI) of the inoculated group was significantly lower than that of the control group at 11 days PI. This response was reversed at 18 days PI, when the SI of the inoculated group was significantly higher than that of the controls; values subsequently returned to baseline. The increase in intracellular calcium levels in CAV-infected chicks and controls paralleled the proliferative response. Percentages of CD3-, CD4-, CD8-, and natural-killer-positive-staining cells decreased significantly at 18 and 25 days PI. The most dramatic decrease occurred in the CD8-positive-staining cell population at 18 and 25 days PI.</description><identifier>ISSN: 0005-2086</identifier><identifier>EISSN: 1938-4351</identifier><identifier>DOI: 10.2307/1591992</identifier><identifier>PMID: 7794172</identifier><language>eng</language><publisher>United States: American Association of Avian Pathologists, Inc</publisher><subject>Animals ; calcio ; Calcium ; Calcium - metabolism ; cell mediated immunity ; cells ; cellule ; celulas ; Chicken anemia virus ; Chicken anemia virus - isolation & purification ; Chicken anemia virus - physiology ; Chickens ; chicks ; Circoviridae Infections - immunology ; Circoviridae Infections - pathology ; enfermedades inmunologicas ; Flow Cytometry ; haematocrit ; Hematocrit ; hematocrite ; hematocrito ; histopathologie ; histopathology ; histopatologia ; Immune Tolerance ; immunite cellulaire ; immunological diseases ; Immunophenotyping ; Infections ; inmunidad celular ; instrument de mesure ; instrumentos de medicion ; linfocitos ; lymphocyte ; Lymphocyte Activation ; Lymphocyte proliferation ; Lymphocytes ; Lymphocytes - immunology ; Lymphocytes - physiology ; Lymphocytes - virology ; maladie immunologique ; measuring instruments ; Natural killer cells ; parvoviridae ; pollito ; poussin ; Reference Values ; Signal Transduction ; Spleen - immunology ; Splenocytes ; T lymphocytes ; Thymus Gland - immunology ; Thymus Gland - pathology ; Viruses</subject><ispartof>Avian diseases, 1995, Vol.39 (1), p.135-140</ispartof><rights>Copyright 1995 The American Association of Avian Pathologists, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c328t-354f22251157adefc83b20d3202866effa05c6b39335571a4bf9d4ac5dcbb8f83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1591992$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1591992$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,4010,27902,27903,27904,57995,58228</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7794172$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bounous, Denise I.</creatorcontrib><creatorcontrib>Goodwin, Mark A.</creatorcontrib><creatorcontrib>Brooks, Randolph L.</creatorcontrib><creatorcontrib>Lamichhane, Chinta M.</creatorcontrib><creatorcontrib>Campagnoli, Raymond P.</creatorcontrib><creatorcontrib>Brown, John</creatorcontrib><creatorcontrib>Snyder, David B.</creatorcontrib><creatorcontrib>South African Poultry Association, Honeydew (South Africa)</creatorcontrib><creatorcontrib>University of Georgia, Athens, GA</creatorcontrib><title>Immunosuppression and intracellular calcium signaling in splenocytes from chicks infected with chicken anemia virus, CL-1 isolate</title><title>Avian diseases</title><addtitle>Avian Dis</addtitle><description>Hematocrits, histopathology, concanavalin A-induced lymphocyte proliferation, intracellular calcium signaling, and lymphocyte subpopulations were analyzed over a 6-week period in individual chicks inoculated with the CL-1 isolate of chicken anemia virus. Lymphoid depletion/atrophy was present in the thymus and bone marrow by 11 days postinfection (PI). Anemia was present at 14 days PI. The mean lymphocyte proliferation stimulation index (SI) of the inoculated group was significantly lower than that of the control group at 11 days PI. This response was reversed at 18 days PI, when the SI of the inoculated group was significantly higher than that of the controls; values subsequently returned to baseline. The increase in intracellular calcium levels in CAV-infected chicks and controls paralleled the proliferative response. Percentages of CD3-, CD4-, CD8-, and natural-killer-positive-staining cells decreased significantly at 18 and 25 days PI. The most dramatic decrease occurred in the CD8-positive-staining cell population at 18 and 25 days PI.</description><subject>Animals</subject><subject>calcio</subject><subject>Calcium</subject><subject>Calcium - metabolism</subject><subject>cell mediated immunity</subject><subject>cells</subject><subject>cellule</subject><subject>celulas</subject><subject>Chicken anemia virus</subject><subject>Chicken anemia virus - isolation & purification</subject><subject>Chicken anemia virus - physiology</subject><subject>Chickens</subject><subject>chicks</subject><subject>Circoviridae Infections - immunology</subject><subject>Circoviridae Infections - pathology</subject><subject>enfermedades inmunologicas</subject><subject>Flow Cytometry</subject><subject>haematocrit</subject><subject>Hematocrit</subject><subject>hematocrite</subject><subject>hematocrito</subject><subject>histopathologie</subject><subject>histopathology</subject><subject>histopatologia</subject><subject>Immune Tolerance</subject><subject>immunite cellulaire</subject><subject>immunological diseases</subject><subject>Immunophenotyping</subject><subject>Infections</subject><subject>inmunidad celular</subject><subject>instrument de mesure</subject><subject>instrumentos de medicion</subject><subject>linfocitos</subject><subject>lymphocyte</subject><subject>Lymphocyte Activation</subject><subject>Lymphocyte proliferation</subject><subject>Lymphocytes</subject><subject>Lymphocytes - immunology</subject><subject>Lymphocytes - physiology</subject><subject>Lymphocytes - virology</subject><subject>maladie immunologique</subject><subject>measuring instruments</subject><subject>Natural killer cells</subject><subject>parvoviridae</subject><subject>pollito</subject><subject>poussin</subject><subject>Reference Values</subject><subject>Signal Transduction</subject><subject>Spleen - immunology</subject><subject>Splenocytes</subject><subject>T lymphocytes</subject><subject>Thymus Gland - immunology</subject><subject>Thymus Gland - pathology</subject><subject>Viruses</subject><issn>0005-2086</issn><issn>1938-4351</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAURYMoOo7iL1CyEN1YzUfTtEsZ_IIBF-q6pGkyZmybmtcqs_Sf26HFpavAO4f78i5CJ5RcM07kDRUZzTK2g2Y042kUc0F30YwQIiJG0uQAHQKsCaEyS8g-2pcyi6lkM_TzVNd946Fv22AAnG-wakrsmi4obaqqr1TAWlXa9TUGt2pU5ZrVwDG0lWm83nQGsA2-xvrd6Q8YkDW6MyX-dt37ODTbUFM7hb9c6OEKL5YRxQ58pTpzhPasqsAcT-8cvd3fvS4eo-Xzw9PidhlpztIu4iK2jDFBqZCqNFanvGCk5IywNEmMtYoInRQ841wISVVc2KyMlRalLorUpnyOLsbcNvjP3kCX1w62Jw5f8z3kUg4rUsYG8XIUdfAAwdi8Da5WYZNTkm_LzqeyB_N0iuyL2pR_3tTuwM9HvobOh39izkbNKp-rVXCQv70MJCEkFkki-S9b_I-y</recordid><startdate>1995</startdate><enddate>1995</enddate><creator>Bounous, Denise I.</creator><creator>Goodwin, Mark A.</creator><creator>Brooks, Randolph L.</creator><creator>Lamichhane, Chinta M.</creator><creator>Campagnoli, Raymond P.</creator><creator>Brown, John</creator><creator>Snyder, David B.</creator><general>American Association of Avian Pathologists, Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1995</creationdate><title>Immunosuppression and intracellular calcium signaling in splenocytes from chicks infected with chicken anemia virus, CL-1 isolate</title><author>Bounous, Denise I. ; Goodwin, Mark A. ; Brooks, Randolph L. ; Lamichhane, Chinta M. ; Campagnoli, Raymond P. ; Brown, John ; Snyder, David B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c328t-354f22251157adefc83b20d3202866effa05c6b39335571a4bf9d4ac5dcbb8f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>calcio</topic><topic>Calcium</topic><topic>Calcium - metabolism</topic><topic>cell mediated immunity</topic><topic>cells</topic><topic>cellule</topic><topic>celulas</topic><topic>Chicken anemia virus</topic><topic>Chicken anemia virus - isolation & purification</topic><topic>Chicken anemia virus - physiology</topic><topic>Chickens</topic><topic>chicks</topic><topic>Circoviridae Infections - immunology</topic><topic>Circoviridae Infections - pathology</topic><topic>enfermedades inmunologicas</topic><topic>Flow Cytometry</topic><topic>haematocrit</topic><topic>Hematocrit</topic><topic>hematocrite</topic><topic>hematocrito</topic><topic>histopathologie</topic><topic>histopathology</topic><topic>histopatologia</topic><topic>Immune Tolerance</topic><topic>immunite cellulaire</topic><topic>immunological diseases</topic><topic>Immunophenotyping</topic><topic>Infections</topic><topic>inmunidad celular</topic><topic>instrument de mesure</topic><topic>instrumentos de medicion</topic><topic>linfocitos</topic><topic>lymphocyte</topic><topic>Lymphocyte Activation</topic><topic>Lymphocyte proliferation</topic><topic>Lymphocytes</topic><topic>Lymphocytes - immunology</topic><topic>Lymphocytes - physiology</topic><topic>Lymphocytes - virology</topic><topic>maladie immunologique</topic><topic>measuring instruments</topic><topic>Natural killer cells</topic><topic>parvoviridae</topic><topic>pollito</topic><topic>poussin</topic><topic>Reference Values</topic><topic>Signal Transduction</topic><topic>Spleen - immunology</topic><topic>Splenocytes</topic><topic>T lymphocytes</topic><topic>Thymus Gland - immunology</topic><topic>Thymus Gland - pathology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bounous, Denise I.</creatorcontrib><creatorcontrib>Goodwin, Mark A.</creatorcontrib><creatorcontrib>Brooks, Randolph L.</creatorcontrib><creatorcontrib>Lamichhane, Chinta M.</creatorcontrib><creatorcontrib>Campagnoli, Raymond P.</creatorcontrib><creatorcontrib>Brown, John</creatorcontrib><creatorcontrib>Snyder, David B.</creatorcontrib><creatorcontrib>South African Poultry Association, Honeydew (South Africa)</creatorcontrib><creatorcontrib>University of Georgia, Athens, GA</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Avian diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bounous, Denise I.</au><au>Goodwin, Mark A.</au><au>Brooks, Randolph L.</au><au>Lamichhane, Chinta M.</au><au>Campagnoli, Raymond P.</au><au>Brown, John</au><au>Snyder, David B.</au><aucorp>South African Poultry Association, Honeydew (South Africa)</aucorp><aucorp>University of Georgia, Athens, GA</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunosuppression and intracellular calcium signaling in splenocytes from chicks infected with chicken anemia virus, CL-1 isolate</atitle><jtitle>Avian diseases</jtitle><addtitle>Avian Dis</addtitle><date>1995</date><risdate>1995</risdate><volume>39</volume><issue>1</issue><spage>135</spage><epage>140</epage><pages>135-140</pages><issn>0005-2086</issn><eissn>1938-4351</eissn><abstract>Hematocrits, histopathology, concanavalin A-induced lymphocyte proliferation, intracellular calcium signaling, and lymphocyte subpopulations were analyzed over a 6-week period in individual chicks inoculated with the CL-1 isolate of chicken anemia virus. Lymphoid depletion/atrophy was present in the thymus and bone marrow by 11 days postinfection (PI). Anemia was present at 14 days PI. The mean lymphocyte proliferation stimulation index (SI) of the inoculated group was significantly lower than that of the control group at 11 days PI. This response was reversed at 18 days PI, when the SI of the inoculated group was significantly higher than that of the controls; values subsequently returned to baseline. The increase in intracellular calcium levels in CAV-infected chicks and controls paralleled the proliferative response. Percentages of CD3-, CD4-, CD8-, and natural-killer-positive-staining cells decreased significantly at 18 and 25 days PI. The most dramatic decrease occurred in the CD8-positive-staining cell population at 18 and 25 days PI.</abstract><cop>United States</cop><pub>American Association of Avian Pathologists, Inc</pub><pmid>7794172</pmid><doi>10.2307/1591992</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Avian diseases, 1995, Vol.39 (1), p.135-140 |
| issn | 0005-2086 1938-4351 |
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| source | Jstor Complete Legacy; MEDLINE |
| subjects | Animals calcio Calcium Calcium - metabolism cell mediated immunity cells cellule celulas Chicken anemia virus Chicken anemia virus - isolation & purification Chicken anemia virus - physiology Chickens chicks Circoviridae Infections - immunology Circoviridae Infections - pathology enfermedades inmunologicas Flow Cytometry haematocrit Hematocrit hematocrite hematocrito histopathologie histopathology histopatologia Immune Tolerance immunite cellulaire immunological diseases Immunophenotyping Infections inmunidad celular instrument de mesure instrumentos de medicion linfocitos lymphocyte Lymphocyte Activation Lymphocyte proliferation Lymphocytes Lymphocytes - immunology Lymphocytes - physiology Lymphocytes - virology maladie immunologique measuring instruments Natural killer cells parvoviridae pollito poussin Reference Values Signal Transduction Spleen - immunology Splenocytes T lymphocytes Thymus Gland - immunology Thymus Gland - pathology Viruses |
| title | Immunosuppression and intracellular calcium signaling in splenocytes from chicks infected with chicken anemia virus, CL-1 isolate |
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