Detection of d-aspartate in tau proteins associated with Alzheimer paired helical filaments

Paired helical filaments (PHF) characteristic of Alzheimer neurofibrillary lesions are known to contain a modified form of microtubule associated protein tau. These proteins, PHF-tau, differ from normal tau in the extent and the site of phosphorylation. To determine whether PHF-tau, tau proteins fro...

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Veröffentlicht in:	Brain research 1995-03, Vol.675 (1), p.183-189
Hauptverfasser:	Kenessey, Agnes, Yen, Shu-Hui, Liu, Wan-Kyng, Yang, Xiao-Ran, Dunlop, David S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Amino Acids - analysis Amino Acids - metabolism Aspartic Acid - analysis Aspartic Acid - metabolism Biological and medical sciences Brain Chemistry - physiology d-Aspartate Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Electrophoresis, Polyacrylamide Gel Female Humans Hydrolysis Immunoblotting Medical sciences Neurofibrillary Tangles - metabolism Neurofibrillary Tangles - pathology Neurology Normal tau PHF-tau Pregnancy tau Proteins - analysis tau Proteins - metabolism
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