Structure-activity studies of sulfate transfer: the hydrolysis and aminolysis of 3′-phosphoadenosine 5′-phosphosulfate (PAPS)

The pH-rate profile for the hydrolysis of 3′-phosphoadenosine 5′-phosphosulfate (PAPS) in aqueous solution has been measured. Comparison with other data suggests that hydrolysis occurs by almost complete unimolecular elimination of sulfur trioxide, with weak involvement of a molecule of water in the...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 1995-02, Vol.3 (2), p.167-172
Hauptverfasser:	Bedford, Colin T., Kirby, Anthony J., Logan, Christopher J., Drummond, Jeremy N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines - chemistry Chromatography, High Pressure Liquid Dimethyl Sulfoxide Hydrogen-Ion Concentration Hydrolysis Kinetics Morpholines - chemistry Osmolar Concentration Phosphoadenosine Phosphosulfate - chemistry Piperazines - chemistry Structure-Activity Relationship Sulfates - chemistry
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