Relationship between elevation in the plasma concentration of elastase-alpha 1 proteinase inhibitor complex (E-alpha 1 PI) and haemostatic parameters during haemodialysis
To investigate the relationship between changes in plasma concentrations of polymorphonuclear elastase (PMN-E) and haemostatic effects during haemodialysis (HD), changes in the plasma concentrations of elastase-alpha 1 proteinase inhibitor complex (E-alpha 1 PI) and fibrinogen (Fbg), cross-linked fi...
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| Veröffentlicht in: | Blood coagulation & fibrinolysis 1995-02, Vol.6 (1), p.5-10 |
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| container_title | Blood coagulation & fibrinolysis |
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| creator | Yamazaki, M Asakura, H Saito, M Jokaji, H Uotani, C Kumabashiri, I Morishita, E Aoshima, K Sato, T Tsugawa, Y |
| description | To investigate the relationship between changes in plasma concentrations of polymorphonuclear elastase (PMN-E) and haemostatic effects during haemodialysis (HD), changes in the plasma concentrations of elastase-alpha 1 proteinase inhibitor complex (E-alpha 1 PI) and fibrinogen (Fbg), cross-linked fibrin degradation products (XDP), thrombin-antithrombin III complex (TAT), plasmin-alpha 2 plasmin inhibitor complex (PIC) and soluble thrombomodulin (TM) in 49 patients with end-stage chronic glomerulonephritis maintained on chronic HD were measured. Plasma concentrations of TAT, PIC, TM and E-alpha 1 PI significantly increased during a single HD. There was a statistically significant correlation between change in plasma E-alpha 1 PI concentration and changes in plasma concentrations of TAT, PIC and TM during a single HD, as well as between changes in plasma concentrations of TM and TAT during a single HD. These observations suggested that activation of coagulation and fibrinolysis, endothelial cell damage, and activation of polymorphonuclear cells occur during HD. Activation of polymorphonuclear cells may induce activation of coagulation and fibrinolysis, leading to endothelial cell damage, augmented by release of proteases such as elastase. |
| format | Article |
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Plasma concentrations of TAT, PIC, TM and E-alpha 1 PI significantly increased during a single HD. There was a statistically significant correlation between change in plasma E-alpha 1 PI concentration and changes in plasma concentrations of TAT, PIC and TM during a single HD, as well as between changes in plasma concentrations of TM and TAT during a single HD. These observations suggested that activation of coagulation and fibrinolysis, endothelial cell damage, and activation of polymorphonuclear cells occur during HD. Activation of polymorphonuclear cells may induce activation of coagulation and fibrinolysis, leading to endothelial cell damage, augmented by release of proteases such as elastase.</description><identifier>ISSN: 0957-5235</identifier><identifier>PMID: 7795153</identifier><language>eng</language><publisher>England</publisher><subject>Adult ; Aged ; alpha 1-Antitrypsin - analysis ; Antithrombin III - analysis ; Blood Cell Count ; Female ; Fibrin Fibrinogen Degradation Products - analysis ; Fibrinogen - analysis ; Fibrinolysis ; Glomerulonephritis - complications ; Hemostasis ; Humans ; Kidney Failure, Chronic - blood ; Kidney Failure, Chronic - etiology ; Kidney Failure, Chronic - therapy ; Leukocyte Elastase ; Male ; Middle Aged ; Pancreatic Elastase - blood ; Peptide Hydrolases - analysis ; Renal Dialysis ; Thrombomodulin - analysis</subject><ispartof>Blood coagulation & fibrinolysis, 1995-02, Vol.6 (1), p.5-10</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7795153$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamazaki, M</creatorcontrib><creatorcontrib>Asakura, H</creatorcontrib><creatorcontrib>Saito, M</creatorcontrib><creatorcontrib>Jokaji, H</creatorcontrib><creatorcontrib>Uotani, C</creatorcontrib><creatorcontrib>Kumabashiri, I</creatorcontrib><creatorcontrib>Morishita, E</creatorcontrib><creatorcontrib>Aoshima, K</creatorcontrib><creatorcontrib>Sato, T</creatorcontrib><creatorcontrib>Tsugawa, Y</creatorcontrib><title>Relationship between elevation in the plasma concentration of elastase-alpha 1 proteinase inhibitor complex (E-alpha 1 PI) and haemostatic parameters during haemodialysis</title><title>Blood coagulation & fibrinolysis</title><addtitle>Blood Coagul Fibrinolysis</addtitle><description>To investigate the relationship between changes in plasma concentrations of polymorphonuclear elastase (PMN-E) and haemostatic effects during haemodialysis (HD), changes in the plasma concentrations of elastase-alpha 1 proteinase inhibitor complex (E-alpha 1 PI) and fibrinogen (Fbg), cross-linked fibrin degradation products (XDP), thrombin-antithrombin III complex (TAT), plasmin-alpha 2 plasmin inhibitor complex (PIC) and soluble thrombomodulin (TM) in 49 patients with end-stage chronic glomerulonephritis maintained on chronic HD were measured. Plasma concentrations of TAT, PIC, TM and E-alpha 1 PI significantly increased during a single HD. There was a statistically significant correlation between change in plasma E-alpha 1 PI concentration and changes in plasma concentrations of TAT, PIC and TM during a single HD, as well as between changes in plasma concentrations of TM and TAT during a single HD. These observations suggested that activation of coagulation and fibrinolysis, endothelial cell damage, and activation of polymorphonuclear cells occur during HD. Activation of polymorphonuclear cells may induce activation of coagulation and fibrinolysis, leading to endothelial cell damage, augmented by release of proteases such as elastase.</description><subject>Adult</subject><subject>Aged</subject><subject>alpha 1-Antitrypsin - analysis</subject><subject>Antithrombin III - analysis</subject><subject>Blood Cell Count</subject><subject>Female</subject><subject>Fibrin Fibrinogen Degradation Products - analysis</subject><subject>Fibrinogen - analysis</subject><subject>Fibrinolysis</subject><subject>Glomerulonephritis - complications</subject><subject>Hemostasis</subject><subject>Humans</subject><subject>Kidney Failure, Chronic - blood</subject><subject>Kidney Failure, Chronic - etiology</subject><subject>Kidney Failure, Chronic - therapy</subject><subject>Leukocyte Elastase</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pancreatic Elastase - blood</subject><subject>Peptide Hydrolases - analysis</subject><subject>Renal Dialysis</subject><subject>Thrombomodulin - analysis</subject><issn>0957-5235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kF9LwzAUxfugzDn9CEKeRB8KadM2y6OMqYOBInsfN-mtjaRpTFL_fCU_pcENny6c8zsH7jnJ5lTUPK9LVp9l5yG8UUpZteSzbMa5qIuazbOfFzQQ9WhDrx2RGD8RLUGDH38q0ZbEHokzEAYgarQKbfQHb-wSCCFCwByM64EUxPkxorZJStFeSx1Hn2KDM_hFbtb_3PPmloBtSQ84jKkiakUceBgwog-knby2rwe31WC-gw4X2WkHJuDl8S6y3f16t3rMt08Pm9XdNnc1Y3lZiU4oVRWUgqoq1iLtpCqlaERTNkXRLbnquKwbVlChpGwK1i1LaKjibStAsEV2fahNr7xPGOJ-0EGhMWBxnMKe87RhGjaBV0dwkgO2e-f1AP57f9yW_QL-o3ha</recordid><startdate>199502</startdate><enddate>199502</enddate><creator>Yamazaki, M</creator><creator>Asakura, H</creator><creator>Saito, M</creator><creator>Jokaji, H</creator><creator>Uotani, C</creator><creator>Kumabashiri, I</creator><creator>Morishita, E</creator><creator>Aoshima, K</creator><creator>Sato, T</creator><creator>Tsugawa, Y</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199502</creationdate><title>Relationship between elevation in the plasma concentration of elastase-alpha 1 proteinase inhibitor complex (E-alpha 1 PI) and haemostatic parameters during haemodialysis</title><author>Yamazaki, M ; Asakura, H ; Saito, M ; Jokaji, H ; Uotani, C ; Kumabashiri, I ; Morishita, E ; Aoshima, K ; Sato, T ; Tsugawa, Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p533-249f9cc4100ac443de0fbc2b96962611f87cf7b563109cbb613f82a60c7dd9a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adult</topic><topic>Aged</topic><topic>alpha 1-Antitrypsin - analysis</topic><topic>Antithrombin III - analysis</topic><topic>Blood Cell Count</topic><topic>Female</topic><topic>Fibrin Fibrinogen Degradation Products - analysis</topic><topic>Fibrinogen - analysis</topic><topic>Fibrinolysis</topic><topic>Glomerulonephritis - complications</topic><topic>Hemostasis</topic><topic>Humans</topic><topic>Kidney Failure, Chronic - blood</topic><topic>Kidney Failure, Chronic - etiology</topic><topic>Kidney Failure, Chronic - therapy</topic><topic>Leukocyte Elastase</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pancreatic Elastase - blood</topic><topic>Peptide Hydrolases - analysis</topic><topic>Renal Dialysis</topic><topic>Thrombomodulin - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamazaki, M</creatorcontrib><creatorcontrib>Asakura, H</creatorcontrib><creatorcontrib>Saito, M</creatorcontrib><creatorcontrib>Jokaji, H</creatorcontrib><creatorcontrib>Uotani, C</creatorcontrib><creatorcontrib>Kumabashiri, I</creatorcontrib><creatorcontrib>Morishita, E</creatorcontrib><creatorcontrib>Aoshima, K</creatorcontrib><creatorcontrib>Sato, T</creatorcontrib><creatorcontrib>Tsugawa, Y</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Blood coagulation & fibrinolysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamazaki, M</au><au>Asakura, H</au><au>Saito, M</au><au>Jokaji, H</au><au>Uotani, C</au><au>Kumabashiri, I</au><au>Morishita, E</au><au>Aoshima, K</au><au>Sato, T</au><au>Tsugawa, Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between elevation in the plasma concentration of elastase-alpha 1 proteinase inhibitor complex (E-alpha 1 PI) and haemostatic parameters during haemodialysis</atitle><jtitle>Blood coagulation & fibrinolysis</jtitle><addtitle>Blood Coagul Fibrinolysis</addtitle><date>1995-02</date><risdate>1995</risdate><volume>6</volume><issue>1</issue><spage>5</spage><epage>10</epage><pages>5-10</pages><issn>0957-5235</issn><abstract>To investigate the relationship between changes in plasma concentrations of polymorphonuclear elastase (PMN-E) and haemostatic effects during haemodialysis (HD), changes in the plasma concentrations of elastase-alpha 1 proteinase inhibitor complex (E-alpha 1 PI) and fibrinogen (Fbg), cross-linked fibrin degradation products (XDP), thrombin-antithrombin III complex (TAT), plasmin-alpha 2 plasmin inhibitor complex (PIC) and soluble thrombomodulin (TM) in 49 patients with end-stage chronic glomerulonephritis maintained on chronic HD were measured. Plasma concentrations of TAT, PIC, TM and E-alpha 1 PI significantly increased during a single HD. There was a statistically significant correlation between change in plasma E-alpha 1 PI concentration and changes in plasma concentrations of TAT, PIC and TM during a single HD, as well as between changes in plasma concentrations of TM and TAT during a single HD. These observations suggested that activation of coagulation and fibrinolysis, endothelial cell damage, and activation of polymorphonuclear cells occur during HD. Activation of polymorphonuclear cells may induce activation of coagulation and fibrinolysis, leading to endothelial cell damage, augmented by release of proteases such as elastase.</abstract><cop>England</cop><pmid>7795153</pmid><tpages>6</tpages></addata></record> |
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| ispartof | Blood coagulation & fibrinolysis, 1995-02, Vol.6 (1), p.5-10 |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Aged alpha 1-Antitrypsin - analysis Antithrombin III - analysis Blood Cell Count Female Fibrin Fibrinogen Degradation Products - analysis Fibrinogen - analysis Fibrinolysis Glomerulonephritis - complications Hemostasis Humans Kidney Failure, Chronic - blood Kidney Failure, Chronic - etiology Kidney Failure, Chronic - therapy Leukocyte Elastase Male Middle Aged Pancreatic Elastase - blood Peptide Hydrolases - analysis Renal Dialysis Thrombomodulin - analysis |
| title | Relationship between elevation in the plasma concentration of elastase-alpha 1 proteinase inhibitor complex (E-alpha 1 PI) and haemostatic parameters during haemodialysis |
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