Blockade of human neutrophil activation by 2-[2-propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]phenoxy]benzoic acid (LY293111), a novel leukotriene B4 receptor antagonist

Leukotriene B4 (LTB4), a naturally occurring pro-inflammatory product of arachidonic acid metabolism, has been associated with human inflammatory disease. This study compares the abilities of two LTB4 receptor antagonists, 2-[2-propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]- propoxy]pheno...

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Veröffentlicht in:	Biochemical pharmacology 1995-05, Vol.49 (11), p.1683-1690
Hauptverfasser:	MARDER, P, SAWYER, J. S, FROELICH, L. L, MANN, L. L, SPAETHE, S. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzoates - pharmacology Benzopyrans - pharmacology Binding, Competitive Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Calcium - metabolism CD11 Antigens - analysis Dose-Response Relationship, Drug Humans Leukotriene B4 - antagonists & inhibitors Leukotriene B4 - pharmacology Medical sciences Neutrophil Activation - drug effects Neutrophils - drug effects Neutrophils - metabolism Pharmacology. Drug treatments Receptors, Leukotriene B4 - antagonists & inhibitors Up-Regulation - drug effects
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