The effects of maternal folic acid and vitamin C nutrition in early pregnancy on reproductive performance in the guinea-pig
1. The effect of different intakes of folic acid (FA) and vitamin C on pregnancy in the Dunkin-Hartley guinea-pig was examined. Female guinea-pigs were subjected to three graded intakes of FA and vitamin C ('deficient', 'intermediate' similar to recommended daily intakes (RDI), a...
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| Veröffentlicht in: | British journal of nutrition 1986-01, Vol.55 (1), p.23-35 |
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| creator | Habibzadeh, N. Schorah, C. J. Smithells, R. W. |
| description | 1. The effect of different intakes of folic acid (FA) and vitamin C on pregnancy in the Dunkin-Hartley guinea-pig was examined. Female guinea-pigs were subjected to three graded intakes of FA and vitamin C ('deficient', 'intermediate' similar to recommended daily intakes (RDI), and 'supplemented') during early gestation and up to the time of neural tube closure (17th day of gestation), and then returned to the RDI of these vitamins. 2. Plasma and blood cell concentrations of these vitamins were measured once before and at the end of the dietary treatments. Reproductive performance was assessed in terms of the number of resorbed and aborted embryos and weight and size of the live fetuses on the 36th day of gestation. 3. The short-term deficiency of either of these two vitamins, insufficient to affect maternal health, had a dramatic effect on the reproductive performance. 4. The RDI of FA was significantly less effective than the supplemented intake in preventing embryonic deaths. The RDI of vitamin C produced lighter and smaller live fetuses than the supplemented intake. 5. The implications of these findings with regard to vitamin status in early pregnancy in man are discussed. |
| doi_str_mv | 10.1079/BJN19860006 |
| format | Article |
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The short-term deficiency of either of these two vitamins, insufficient to affect maternal health, had a dramatic effect on the reproductive performance. 4. The RDI of FA was significantly less effective than the supplemented intake in preventing embryonic deaths. The RDI of vitamin C produced lighter and smaller live fetuses than the supplemented intake. 5. The implications of these findings with regard to vitamin status in early pregnancy in man are discussed.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1079/BJN19860006</identifier><identifier>PMID: 3663576</identifier><identifier>CODEN: BJNUAV</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Animals ; Ascorbic Acid - administration & dosage ; Biological and medical sciences ; Diet ; Female ; Fetal Death - prevention & control ; Fetus - drug effects ; Folic Acid - administration & dosage ; Fundamental and applied biological sciences. Psychology ; Guinea Pigs ; Litter Size - drug effects ; Mother. Fetoplacental unit. Mammary gland. Milk ; Nutritional Requirements ; Papers of direct relevance to Clinical and Human Nutrition ; Pregnancy ; Pregnancy, Animal - drug effects ; Pregnancy. Parturition. 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J.</creatorcontrib><creatorcontrib>Smithells, R. W.</creatorcontrib><title>The effects of maternal folic acid and vitamin C nutrition in early pregnancy on reproductive performance in the guinea-pig</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>1. The effect of different intakes of folic acid (FA) and vitamin C on pregnancy in the Dunkin-Hartley guinea-pig was examined. Female guinea-pigs were subjected to three graded intakes of FA and vitamin C ('deficient', 'intermediate' similar to recommended daily intakes (RDI), and 'supplemented') during early gestation and up to the time of neural tube closure (17th day of gestation), and then returned to the RDI of these vitamins. 2. Plasma and blood cell concentrations of these vitamins were measured once before and at the end of the dietary treatments. Reproductive performance was assessed in terms of the number of resorbed and aborted embryos and weight and size of the live fetuses on the 36th day of gestation. 3. The short-term deficiency of either of these two vitamins, insufficient to affect maternal health, had a dramatic effect on the reproductive performance. 4. The RDI of FA was significantly less effective than the supplemented intake in preventing embryonic deaths. The RDI of vitamin C produced lighter and smaller live fetuses than the supplemented intake. 5. The implications of these findings with regard to vitamin status in early pregnancy in man are discussed.</description><subject>Animals</subject><subject>Ascorbic Acid - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Diet</subject><subject>Female</subject><subject>Fetal Death - prevention & control</subject><subject>Fetus - drug effects</subject><subject>Folic Acid - administration & dosage</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Guinea Pigs</subject><subject>Litter Size - drug effects</subject><subject>Mother. Fetoplacental unit. Mammary gland. Milk</subject><subject>Nutritional Requirements</subject><subject>Papers of direct relevance to Clinical and Human Nutrition</subject><subject>Pregnancy</subject><subject>Pregnancy, Animal - drug effects</subject><subject>Pregnancy. Parturition. Lactation</subject><subject>Reproduction - drug effects</subject><subject>Vertebrates: reproduction</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkc2LFDEQxYMo67h68izkIF6kNUl3Ut1Hd3R3lUURRvEW0kn1mLW_TNKLg_-8GWYYPXgqqt6PqscrQp5y9oozaF5ffPjIm1oxxtQ9suIVyEIoJe6TVR5BwXklH5JHMd7mtuasOSNnpVKlBLUivzffkWLXoU2RTh0dTMIwmp52U-8tNdY7akZH73wygx_pmo5LCj75aaS5RRP6HZ0Dbkcz2h3N04BzmNxik79DOmPopjBkDfd4yse2ix_RFLPfPiYPOtNHfHKs5-TL5bvN-rq4-XT1fv3mprCVUKkAJnnJ27YBi7WoTVOZpmWyBOCmVVY5JwQTvFZOuRagZaAcAAjGeGNb2ZTn5MVhbzb2c8GY9OCjxb43I05L1ABlVYmGZ_DlAbRhijFgp-fgBxN2mjO9j1r_E3Wmnx3XLu2A7sQes83686NuojV9F3IKPp6wmvGay_3R4oD5mPDXSTbhh1ZQgtTq6rP-9vaylF831xr-8tYMbfBui_p2WvY_i_-1-Qdvr6Mj</recordid><startdate>198601</startdate><enddate>198601</enddate><creator>Habibzadeh, N.</creator><creator>Schorah, C. J.</creator><creator>Smithells, R. W.</creator><general>Cambridge University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198601</creationdate><title>The effects of maternal folic acid and vitamin C nutrition in early pregnancy on reproductive performance in the guinea-pig</title><author>Habibzadeh, N. ; Schorah, C. J. ; Smithells, R. W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-705131bb97ce828a94a9b053771ab6c6dd2202186d6db77b076d77720019cb593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Animals</topic><topic>Ascorbic Acid - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>Diet</topic><topic>Female</topic><topic>Fetal Death - prevention & control</topic><topic>Fetus - drug effects</topic><topic>Folic Acid - administration & dosage</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Guinea Pigs</topic><topic>Litter Size - drug effects</topic><topic>Mother. Fetoplacental unit. Mammary gland. Milk</topic><topic>Nutritional Requirements</topic><topic>Papers of direct relevance to Clinical and Human Nutrition</topic><topic>Pregnancy</topic><topic>Pregnancy, Animal - drug effects</topic><topic>Pregnancy. Parturition. Lactation</topic><topic>Reproduction - drug effects</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Habibzadeh, N.</creatorcontrib><creatorcontrib>Schorah, C. J.</creatorcontrib><creatorcontrib>Smithells, R. W.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Habibzadeh, N.</au><au>Schorah, C. J.</au><au>Smithells, R. W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of maternal folic acid and vitamin C nutrition in early pregnancy on reproductive performance in the guinea-pig</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>1986-01</date><risdate>1986</risdate><volume>55</volume><issue>1</issue><spage>23</spage><epage>35</epage><pages>23-35</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><coden>BJNUAV</coden><abstract>1. The effect of different intakes of folic acid (FA) and vitamin C on pregnancy in the Dunkin-Hartley guinea-pig was examined. Female guinea-pigs were subjected to three graded intakes of FA and vitamin C ('deficient', 'intermediate' similar to recommended daily intakes (RDI), and 'supplemented') during early gestation and up to the time of neural tube closure (17th day of gestation), and then returned to the RDI of these vitamins. 2. Plasma and blood cell concentrations of these vitamins were measured once before and at the end of the dietary treatments. Reproductive performance was assessed in terms of the number of resorbed and aborted embryos and weight and size of the live fetuses on the 36th day of gestation. 3. The short-term deficiency of either of these two vitamins, insufficient to affect maternal health, had a dramatic effect on the reproductive performance. 4. The RDI of FA was significantly less effective than the supplemented intake in preventing embryonic deaths. The RDI of vitamin C produced lighter and smaller live fetuses than the supplemented intake. 5. The implications of these findings with regard to vitamin status in early pregnancy in man are discussed.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>3663576</pmid><doi>10.1079/BJN19860006</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Animals Ascorbic Acid - administration & dosage Biological and medical sciences Diet Female Fetal Death - prevention & control Fetus - drug effects Folic Acid - administration & dosage Fundamental and applied biological sciences. Psychology Guinea Pigs Litter Size - drug effects Mother. Fetoplacental unit. Mammary gland. Milk Nutritional Requirements Papers of direct relevance to Clinical and Human Nutrition Pregnancy Pregnancy, Animal - drug effects Pregnancy. Parturition. Lactation Reproduction - drug effects Vertebrates: reproduction |
| title | The effects of maternal folic acid and vitamin C nutrition in early pregnancy on reproductive performance in the guinea-pig |
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