A New Cytochrome P450 Form Belonging to the CYP2D in Dog Liver Microsomes: Purification, cDNA Cloning, and Enzyme Characterization

A new form of cytochrome P450 (P450 DUT2) was purified from untreated male dog liver microsomes. The final preparation (a specific content of 19.1 nmol P450/mg protein) showed a single band with an apparent monomeric molecular weight of 50,000 on sodium dodecyl sulfate-polyacrylamide gel electrophor...

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Veröffentlicht in:	Archives of biochemistry and biophysics 1995-06, Vol.319 (2), p.372-382
Hauptverfasser:	Sakamoto, K., Kirita, S., Baba, T., Nakamura, Y., Yamazoe, Y., Kato, R., Takanaka, A., Matsubara, T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Base Sequence Cloning, Molecular Cytochrome P-450 CYP2D6 Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - isolation & purification Cytochrome P-450 Enzyme System - metabolism DNA, Complementary - isolation & purification Dogs Enzyme Activation Female Male Microsomes, Liver - enzymology Mixed Function Oxygenases - genetics Mixed Function Oxygenases - isolation & purification Mixed Function Oxygenases - metabolism Molecular Sequence Data Sequence Analysis
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