A severe loss of choline acetyltransferase in the frontal cortex of Alzheimer patients carrying apolipoprotein epsilon 4 allele

We measured the activities of choline acetyltransferase (ChAT) in the post mortem frontal cortex in 32 Alzheimer's disease (AD) patients with different apolipoprotein E (apoE) genotypes. The ChAT values were significantly lower for the AD patients with 2 epsilon 4 alleles than for those with 0...

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Veröffentlicht in:	Neuroscience letters 1995-03, Vol.187 (2), p.79-82
Hauptverfasser:	Soininen, H, Kosunen, O, Helisalmi, S, Mannermaa, A, Paljärvi, L, Talasniemi, S, Ryynänen, M, Riekkinen, Sr, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alleles Alzheimer Disease - enzymology Alzheimer Disease - genetics Apolipoprotein E4 Apolipoproteins E - genetics Choline O-Acetyltransferase - metabolism Female Frontal Lobe - enzymology Humans Male
Online-Zugang:	Volltext
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