γ Chain-associated Cytokine Receptors Signal through Distinct Transducing Factors
The IL-2, IL-4, and IL-7 signaling pathways have been shown to utilize shared components. The receptors for these cytokines are composed of ligand-specific binding chains that associate with a shared signaling subunit, the common γ (γc) chain. In addition, IL-2, IL-4, and IL-7 induce activation of a...
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| Veröffentlicht in: | The Journal of biological chemistry 1995-06, Vol.270 (24), p.14517-14522 |
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| container_end_page | 14522 |
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| container_issue | 24 |
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| container_title | The Journal of biological chemistry |
| container_volume | 270 |
| creator | Pernis, Alessandra Gupta, Sanjay Yopp, James Garfein, Evan Kashleva, Helena Schindler, Chris Rothman, Paul |
| description | The IL-2, IL-4, and IL-7 signaling pathways have been shown to utilize shared components. The receptors for these cytokines are composed of ligand-specific binding chains that associate with a shared signaling subunit, the common γ (γc) chain. In addition, IL-2, IL-4, and IL-7 induce activation of a common set of nonreceptor tyrosine kinases, Jak-1 and Jak-3. We have further investigated the signaling events induced by these cytokines and find that the γc-associated receptors activate distinct signal transducing factors (STFs). In addition, we show that a 94-kDa STAT-related protein (p94) is activated in response to IL-2 and IL-7, but not IL-4. These data indicate that IL-2, IL-4, and IL-7 activate distinct signaling molecules which might be differentially recruited to the receptor complex by the ligand-specific units of the IL-2, IL-4, and IL-7 receptors. |
| doi_str_mv | 10.1074/jbc.270.24.14517 |
| format | Article |
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The receptors for these cytokines are composed of ligand-specific binding chains that associate with a shared signaling subunit, the common γ (γc) chain. In addition, IL-2, IL-4, and IL-7 induce activation of a common set of nonreceptor tyrosine kinases, Jak-1 and Jak-3. We have further investigated the signaling events induced by these cytokines and find that the γc-associated receptors activate distinct signal transducing factors (STFs). In addition, we show that a 94-kDa STAT-related protein (p94) is activated in response to IL-2 and IL-7, but not IL-4. 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These data indicate that IL-2, IL-4, and IL-7 activate distinct signaling molecules which might be differentially recruited to the receptor complex by the ligand-specific units of the IL-2, IL-4, and IL-7 receptors.</description><subject>Amino Acid Sequence</subject><subject>Base Sequence</subject><subject>Cell Line</subject><subject>Humans</subject><subject>Interleukins - metabolism</subject><subject>Molecular Sequence Data</subject><subject>Phosphorylation</subject><subject>Receptors, Interleukin - metabolism</subject><subject>Signal Transduction</subject><subject>Tyrosine - metabolism</subject><issn>0021-9258</issn><issn>1083-351X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkL9u2zAQxokiheOk2bsE0JRNLk-URKpb4MZNgQAFHAfoRlCnk03XlhySKuDnynv0mUrHRrag33LAfX-GH2OfgU-Ay_zLusZJJvkkyyeQFyA_sDFwJVJRwK8zNuY8g7TKCnXOLrxf86i8ghEbSakyAfmYzf--JNOVsV1qvO_RmkBNMt2H_rftKJkT0i70ziePdtmZTRJWrh-Wq-Sb9cF2GJKFM51vBrTdMpkZPGQ_sY-t2Xi6Ot1L9jS7W0zv04ef339Mbx9SzEGFFKUBoUpV8UoA8tZIqmqqCVrBJbaCKuTxlRWiUbKhom4L1UoooUAgFLW4ZDfH3Z3rnwfyQW-tR9psTEf94LWUQihZlv8NQllFiSwG-TGIrvfeUat3zm6N22vg-sBbR9468tZZrl95x8r1aXuot9S8FU6Ao__16FMk8ceS0x4tdUiNdYRBN719f_wflZqQnw</recordid><startdate>19950616</startdate><enddate>19950616</enddate><creator>Pernis, Alessandra</creator><creator>Gupta, Sanjay</creator><creator>Yopp, James</creator><creator>Garfein, Evan</creator><creator>Kashleva, Helena</creator><creator>Schindler, Chris</creator><creator>Rothman, Paul</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19950616</creationdate><title>γ Chain-associated Cytokine Receptors Signal through Distinct Transducing Factors</title><author>Pernis, Alessandra ; Gupta, Sanjay ; Yopp, James ; Garfein, Evan ; Kashleva, Helena ; Schindler, Chris ; Rothman, Paul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-c7a1386890931c0fa7e9bebe1f307cf3e9c07e9253d87de5bf58f71615c1ec3b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Amino Acid Sequence</topic><topic>Base Sequence</topic><topic>Cell Line</topic><topic>Humans</topic><topic>Interleukins - metabolism</topic><topic>Molecular Sequence Data</topic><topic>Phosphorylation</topic><topic>Receptors, Interleukin - metabolism</topic><topic>Signal Transduction</topic><topic>Tyrosine - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pernis, Alessandra</creatorcontrib><creatorcontrib>Gupta, Sanjay</creatorcontrib><creatorcontrib>Yopp, James</creatorcontrib><creatorcontrib>Garfein, Evan</creatorcontrib><creatorcontrib>Kashleva, Helena</creatorcontrib><creatorcontrib>Schindler, Chris</creatorcontrib><creatorcontrib>Rothman, Paul</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of biological chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pernis, Alessandra</au><au>Gupta, Sanjay</au><au>Yopp, James</au><au>Garfein, Evan</au><au>Kashleva, Helena</au><au>Schindler, Chris</au><au>Rothman, Paul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>γ Chain-associated Cytokine Receptors Signal through Distinct Transducing Factors</atitle><jtitle>The Journal of biological chemistry</jtitle><addtitle>J Biol Chem</addtitle><date>1995-06-16</date><risdate>1995</risdate><volume>270</volume><issue>24</issue><spage>14517</spage><epage>14522</epage><pages>14517-14522</pages><issn>0021-9258</issn><eissn>1083-351X</eissn><abstract>The IL-2, IL-4, and IL-7 signaling pathways have been shown to utilize shared components. 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| fulltext | fulltext |
| identifier | ISSN: 0021-9258 |
| ispartof | The Journal of biological chemistry, 1995-06, Vol.270 (24), p.14517-14522 |
| issn | 0021-9258 1083-351X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77338766 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Amino Acid Sequence Base Sequence Cell Line Humans Interleukins - metabolism Molecular Sequence Data Phosphorylation Receptors, Interleukin - metabolism Signal Transduction Tyrosine - metabolism |
| title | γ Chain-associated Cytokine Receptors Signal through Distinct Transducing Factors |
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