Whole blood concentrations of chloroquine and desethylchloroquine during and after treatment of adult patients infected with Plasmodium vivax, P. ovale or P. malariae
Whole blood concentrations of chloroquine and desethychloroquine were determined during and after chloroquine treatment of 15 adult patients infected with P. vivax, P. ovale or P. malariae. The median of chloroquine concentrations remained practically unchanged in samples drawn three hours after ini...
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| Veröffentlicht in: | Transactions of the Royal Society of Tropical Medicine and Hygiene 1986, Vol.80 (5), p.763-766 |
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| container_title | Transactions of the Royal Society of Tropical Medicine and Hygiene |
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| creator | Rombo, Lars Björkman, Anders Sego, Emilia Ericsson, Örjan |
| description | Whole blood concentrations of chloroquine and desethychloroquine were determined during and after chloroquine treatment of 15 adult patients infected with
P. vivax,
P. ovale or
P. malariae. The median of chloroquine concentrations remained practically unchanged in samples drawn three hours after initiation of treatment and in samples drawn immediately before the next dose of chloroquine. Concentrations of chloroquine remained above 1·0 μmol/litre for at least four days. The calculated sum of chloroquine and desethylchloroquine concentrations was above 1·0 μmol/litre for at least seven days. These concentrations are regarded as sufficient for treatment of
P. vivax,
P. ovale and
P. malariae infections. |
| doi_str_mv | 10.1016/0035-9203(86)90380-9 |
| format | Article |
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P. vivax,
P. ovale or
P. malariae. The median of chloroquine concentrations remained practically unchanged in samples drawn three hours after initiation of treatment and in samples drawn immediately before the next dose of chloroquine. Concentrations of chloroquine remained above 1·0 μmol/litre for at least four days. The calculated sum of chloroquine and desethylchloroquine concentrations was above 1·0 μmol/litre for at least seven days. These concentrations are regarded as sufficient for treatment of
P. vivax,
P. ovale and
P. malariae infections.</description><identifier>ISSN: 0035-9203</identifier><identifier>EISSN: 1878-3503</identifier><identifier>DOI: 10.1016/0035-9203(86)90380-9</identifier><identifier>PMID: 3299893</identifier><identifier>CODEN: TRSTAZ</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adult ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiparasitic agents ; Biological and medical sciences ; Chloroquine - analogs & derivatives ; Chloroquine - blood ; Chloroquine - therapeutic use ; Female ; Human protozoal diseases ; Humans ; Infectious diseases ; Malaria ; Malaria - blood ; Malaria - drug therapy ; Male ; Medical sciences ; Middle Aged ; Parasitic diseases ; Pharmacology. Drug treatments ; Plasmodium malariae ; Plasmodium vivax ; Protozoal diseases ; Time Factors ; Tropical medicine</subject><ispartof>Transactions of the Royal Society of Tropical Medicine and Hygiene, 1986, Vol.80 (5), p.763-766</ispartof><rights>1986</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2713-d3d59e52a3b7c0b07259b8ce692deb83ead931bb98254aab2862b788cd60e3b3</citedby><cites>FETCH-LOGICAL-c2713-d3d59e52a3b7c0b07259b8ce692deb83ead931bb98254aab2862b788cd60e3b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7950569$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3299893$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rombo, Lars</creatorcontrib><creatorcontrib>Björkman, Anders</creatorcontrib><creatorcontrib>Sego, Emilia</creatorcontrib><creatorcontrib>Ericsson, Örjan</creatorcontrib><title>Whole blood concentrations of chloroquine and desethylchloroquine during and after treatment of adult patients infected with Plasmodium vivax, P. ovale or P. malariae</title><title>Transactions of the Royal Society of Tropical Medicine and Hygiene</title><addtitle>Trans R Soc Trop Med Hyg</addtitle><description>Whole blood concentrations of chloroquine and desethychloroquine were determined during and after chloroquine treatment of 15 adult patients infected with
P. vivax,
P. ovale or
P. malariae. The median of chloroquine concentrations remained practically unchanged in samples drawn three hours after initiation of treatment and in samples drawn immediately before the next dose of chloroquine. Concentrations of chloroquine remained above 1·0 μmol/litre for at least four days. The calculated sum of chloroquine and desethylchloroquine concentrations was above 1·0 μmol/litre for at least seven days. These concentrations are regarded as sufficient for treatment of
P. vivax,
P. ovale and
P. malariae infections.</description><subject>Adult</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Chloroquine - analogs & derivatives</subject><subject>Chloroquine - blood</subject><subject>Chloroquine - therapeutic use</subject><subject>Female</subject><subject>Human protozoal diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Malaria</subject><subject>Malaria - blood</subject><subject>Malaria - drug therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Parasitic diseases</subject><subject>Pharmacology. Drug treatments</subject><subject>Plasmodium malariae</subject><subject>Plasmodium vivax</subject><subject>Protozoal diseases</subject><subject>Time Factors</subject><subject>Tropical medicine</subject><issn>0035-9203</issn><issn>1878-3503</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kdFqFDEUhgdR6rb6Bgq5EFFwambSzCQ3ghR1lQULFirehJPkjBvNTLZJZtu-kM_pTHdZvPIq4fzf-Tnn_EXxrKKnFa2at5QyXsqasleieS0pE7SUD4pFJVpRMk7Zw2JxQB4Xxyn9orTmFZdHxRGrpRSSLYo_V-vgkWgfgiUmDAaHHCG7MCQSOmLWPsRwPboBCQyWWEyY13f-37odoxt-3svQZYwkR4TcT0azA9jRZ7KZLKdCIm7o0GS05MblNbnwkPpg3diTrdvC7RtycUrCFqaJQpz_PXiIDvBJ8agDn_Dp_j0pLj9-uDxflquvnz6fv1-Vpm4rVlpmuUReA9OtoZq2NZdaGGxkbVELhmAlq7SWouZnALoWTa1bIYxtKDLNToqXO9vNvBymrHqXDHoPA4YxqbZljLNKTuDZDjQxpBSxU5voeoh3qqJqTkfNp1fz6ZVo1H06am57vvcfdY_20LSPY9Jf7HVIBnwXYTAuHbBWcsqb2abcYS5lvD3IEH-rpmUtV8vvPxRj35ar1Reqrib-3Y7H6XRbh1ElM8Vh0Lo4paFscP-f-y9-pb4r</recordid><startdate>1986</startdate><enddate>1986</enddate><creator>Rombo, Lars</creator><creator>Björkman, Anders</creator><creator>Sego, Emilia</creator><creator>Ericsson, Örjan</creator><general>Elsevier Ltd</general><general>Royal Society of Tropical Medicine and Hygiene</general><general>Elsevier</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1986</creationdate><title>Whole blood concentrations of chloroquine and desethylchloroquine during and after treatment of adult patients infected with Plasmodium vivax, P. ovale or P. malariae</title><author>Rombo, Lars ; Björkman, Anders ; Sego, Emilia ; Ericsson, Örjan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2713-d3d59e52a3b7c0b07259b8ce692deb83ead931bb98254aab2862b788cd60e3b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Adult</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antiparasitic agents</topic><topic>Biological and medical sciences</topic><topic>Chloroquine - analogs & derivatives</topic><topic>Chloroquine - blood</topic><topic>Chloroquine - therapeutic use</topic><topic>Female</topic><topic>Human protozoal diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Malaria</topic><topic>Malaria - blood</topic><topic>Malaria - drug therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Parasitic diseases</topic><topic>Pharmacology. Drug treatments</topic><topic>Plasmodium malariae</topic><topic>Plasmodium vivax</topic><topic>Protozoal diseases</topic><topic>Time Factors</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rombo, Lars</creatorcontrib><creatorcontrib>Björkman, Anders</creatorcontrib><creatorcontrib>Sego, Emilia</creatorcontrib><creatorcontrib>Ericsson, Örjan</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transactions of the Royal Society of Tropical Medicine and Hygiene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rombo, Lars</au><au>Björkman, Anders</au><au>Sego, Emilia</au><au>Ericsson, Örjan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Whole blood concentrations of chloroquine and desethylchloroquine during and after treatment of adult patients infected with Plasmodium vivax, P. ovale or P. malariae</atitle><jtitle>Transactions of the Royal Society of Tropical Medicine and Hygiene</jtitle><addtitle>Trans R Soc Trop Med Hyg</addtitle><date>1986</date><risdate>1986</risdate><volume>80</volume><issue>5</issue><spage>763</spage><epage>766</epage><pages>763-766</pages><issn>0035-9203</issn><eissn>1878-3503</eissn><coden>TRSTAZ</coden><abstract>Whole blood concentrations of chloroquine and desethychloroquine were determined during and after chloroquine treatment of 15 adult patients infected with
P. vivax,
P. ovale or
P. malariae. The median of chloroquine concentrations remained practically unchanged in samples drawn three hours after initiation of treatment and in samples drawn immediately before the next dose of chloroquine. Concentrations of chloroquine remained above 1·0 μmol/litre for at least four days. The calculated sum of chloroquine and desethylchloroquine concentrations was above 1·0 μmol/litre for at least seven days. These concentrations are regarded as sufficient for treatment of
P. vivax,
P. ovale and
P. malariae infections.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>3299893</pmid><doi>10.1016/0035-9203(86)90380-9</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0035-9203 |
| ispartof | Transactions of the Royal Society of Tropical Medicine and Hygiene, 1986, Vol.80 (5), p.763-766 |
| issn | 0035-9203 1878-3503 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic agents Biological and medical sciences Chloroquine - analogs & derivatives Chloroquine - blood Chloroquine - therapeutic use Female Human protozoal diseases Humans Infectious diseases Malaria Malaria - blood Malaria - drug therapy Male Medical sciences Middle Aged Parasitic diseases Pharmacology. Drug treatments Plasmodium malariae Plasmodium vivax Protozoal diseases Time Factors Tropical medicine |
| title | Whole blood concentrations of chloroquine and desethylchloroquine during and after treatment of adult patients infected with Plasmodium vivax, P. ovale or P. malariae |
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