Adipokinetic hormone stimulates neurones in the insect central nervous system
A simple preparation designed to screen and compare the central action of putative neuroactive agents in the moth Manduca sexta is described. This approach combines microinjections into the central nervous system with myograms recorded from a pair of spontaneously active mesothoracic muscles. Pressu...
Gespeichert in:
| Veröffentlicht in: | Journal of experimental biology 1995-06, Vol.198 (Pt 6), p.1307-1311 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1311 |
|---|---|
| container_issue | Pt 6 |
| container_start_page | 1307 |
| container_title | Journal of experimental biology |
| container_volume | 198 |
| creator | Milde, J J Ziegler, R Wallstein, M |
| description | A simple preparation designed to screen and compare the central action of putative neuroactive agents in the moth Manduca sexta is described. This approach combines microinjections into the central nervous system with myograms recorded from a pair of spontaneously active mesothoracic muscles. Pressure injection of either octopamine or Manduca adipokinetic hormone (M-AKH) into the mesothoracic neuropile increases the monitored motor activity. Under the conditions used, the excitatory effects of M-AKH exceed those of the potent neuromodulator octopamine. This suggests that M-AKH plays a role in the central nervous system in addition to its known metabolic functions and supports recent evidence that neuropeptides in insects can be multifunctional. |
| doi_str_mv | 10.1242/jeb.198.6.1307 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_77334984</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>15829856</sourcerecordid><originalsourceid>FETCH-LOGICAL-c300t-5f7d512e1e751dfb85edebb6adbd5f90be7f59131cd898bc228a1d3c09e8aaa23</originalsourceid><addsrcrecordid>eNqFkbtPwzAQxi0EKqWwsiFFDGwJfsSxPVYVLwnEArPl2Bc1JY9iO0j897hqxcDCLSfd_e7T3X0IXRJcEFrS2w3UBVGyqArCsDhCc1IKkStS8mM0x5jSHKtSnaKzEDY4RcXLGZoJIakgco5elq7djh_tALG12Xr0_ThAFmLbT52JELIBJp9KIWuHLK4hpQA2ZhaG6E2X2v5rnEIWvkOE_hydNKYLcHHIC_R-f_e2esyfXx-eVsvn3DKMY84b4TihQEBw4ppacnBQ15VxteONwjWIhivCiHVSydpSKg1xzGIF0hhD2QLd7HW3fvycIETdt8FC15kB0jZaCMZKJct_QcIlVZJXCbz-A27GyQ_pCE0ZZlTwaqdW7CHrxxA8NHrr2974b02w3rmhkxs6uaErvXMjDVwdVKe6B_eLH97PfgBQZYcD</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>230327564</pqid></control><display><type>article</type><title>Adipokinetic hormone stimulates neurones in the insect central nervous system</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Company of Biologists</source><creator>Milde, J J ; Ziegler, R ; Wallstein, M</creator><creatorcontrib>Milde, J J ; Ziegler, R ; Wallstein, M</creatorcontrib><description>A simple preparation designed to screen and compare the central action of putative neuroactive agents in the moth Manduca sexta is described. This approach combines microinjections into the central nervous system with myograms recorded from a pair of spontaneously active mesothoracic muscles. Pressure injection of either octopamine or Manduca adipokinetic hormone (M-AKH) into the mesothoracic neuropile increases the monitored motor activity. Under the conditions used, the excitatory effects of M-AKH exceed those of the potent neuromodulator octopamine. This suggests that M-AKH plays a role in the central nervous system in addition to its known metabolic functions and supports recent evidence that neuropeptides in insects can be multifunctional.</description><identifier>ISSN: 0022-0949</identifier><identifier>EISSN: 1477-9145</identifier><identifier>DOI: 10.1242/jeb.198.6.1307</identifier><identifier>PMID: 7782718</identifier><identifier>CODEN: JEBIAM</identifier><language>eng</language><publisher>England: The Company of Biologists Ltd</publisher><subject>Amino Acid Sequence ; Animals ; Cellular biology ; Central Nervous System - drug effects ; Central Nervous System - physiology ; Hormones ; Insect Hormones - administration & dosage ; Insect Hormones - pharmacology ; Insects ; Manduca - drug effects ; Manduca - physiology ; Manduca sexta ; Molecular Sequence Data ; Nervous system ; Neurons ; Neurons - drug effects ; Neurons - physiology ; Octopamine - pharmacology ; Oligopeptides - administration & dosage ; Oligopeptides - pharmacology ; Pyrrolidonecarboxylic Acid - analogs & derivatives</subject><ispartof>Journal of experimental biology, 1995-06, Vol.198 (Pt 6), p.1307-1311</ispartof><rights>Copyright Company of Biologists Limited, Department of Zoology Jun 1995</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c300t-5f7d512e1e751dfb85edebb6adbd5f90be7f59131cd898bc228a1d3c09e8aaa23</citedby><cites>FETCH-LOGICAL-c300t-5f7d512e1e751dfb85edebb6adbd5f90be7f59131cd898bc228a1d3c09e8aaa23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3678,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7782718$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Milde, J J</creatorcontrib><creatorcontrib>Ziegler, R</creatorcontrib><creatorcontrib>Wallstein, M</creatorcontrib><title>Adipokinetic hormone stimulates neurones in the insect central nervous system</title><title>Journal of experimental biology</title><addtitle>J Exp Biol</addtitle><description>A simple preparation designed to screen and compare the central action of putative neuroactive agents in the moth Manduca sexta is described. This approach combines microinjections into the central nervous system with myograms recorded from a pair of spontaneously active mesothoracic muscles. Pressure injection of either octopamine or Manduca adipokinetic hormone (M-AKH) into the mesothoracic neuropile increases the monitored motor activity. Under the conditions used, the excitatory effects of M-AKH exceed those of the potent neuromodulator octopamine. This suggests that M-AKH plays a role in the central nervous system in addition to its known metabolic functions and supports recent evidence that neuropeptides in insects can be multifunctional.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Cellular biology</subject><subject>Central Nervous System - drug effects</subject><subject>Central Nervous System - physiology</subject><subject>Hormones</subject><subject>Insect Hormones - administration & dosage</subject><subject>Insect Hormones - pharmacology</subject><subject>Insects</subject><subject>Manduca - drug effects</subject><subject>Manduca - physiology</subject><subject>Manduca sexta</subject><subject>Molecular Sequence Data</subject><subject>Nervous system</subject><subject>Neurons</subject><subject>Neurons - drug effects</subject><subject>Neurons - physiology</subject><subject>Octopamine - pharmacology</subject><subject>Oligopeptides - administration & dosage</subject><subject>Oligopeptides - pharmacology</subject><subject>Pyrrolidonecarboxylic Acid - analogs & derivatives</subject><issn>0022-0949</issn><issn>1477-9145</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkbtPwzAQxi0EKqWwsiFFDGwJfsSxPVYVLwnEArPl2Bc1JY9iO0j897hqxcDCLSfd_e7T3X0IXRJcEFrS2w3UBVGyqArCsDhCc1IKkStS8mM0x5jSHKtSnaKzEDY4RcXLGZoJIakgco5elq7djh_tALG12Xr0_ThAFmLbT52JELIBJp9KIWuHLK4hpQA2ZhaG6E2X2v5rnEIWvkOE_hydNKYLcHHIC_R-f_e2esyfXx-eVsvn3DKMY84b4TihQEBw4ppacnBQ15VxteONwjWIhivCiHVSydpSKg1xzGIF0hhD2QLd7HW3fvycIETdt8FC15kB0jZaCMZKJct_QcIlVZJXCbz-A27GyQ_pCE0ZZlTwaqdW7CHrxxA8NHrr2974b02w3rmhkxs6uaErvXMjDVwdVKe6B_eLH97PfgBQZYcD</recordid><startdate>199506</startdate><enddate>199506</enddate><creator>Milde, J J</creator><creator>Ziegler, R</creator><creator>Wallstein, M</creator><general>The Company of Biologists Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>199506</creationdate><title>Adipokinetic hormone stimulates neurones in the insect central nervous system</title><author>Milde, J J ; Ziegler, R ; Wallstein, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c300t-5f7d512e1e751dfb85edebb6adbd5f90be7f59131cd898bc228a1d3c09e8aaa23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Cellular biology</topic><topic>Central Nervous System - drug effects</topic><topic>Central Nervous System - physiology</topic><topic>Hormones</topic><topic>Insect Hormones - administration & dosage</topic><topic>Insect Hormones - pharmacology</topic><topic>Insects</topic><topic>Manduca - drug effects</topic><topic>Manduca - physiology</topic><topic>Manduca sexta</topic><topic>Molecular Sequence Data</topic><topic>Nervous system</topic><topic>Neurons</topic><topic>Neurons - drug effects</topic><topic>Neurons - physiology</topic><topic>Octopamine - pharmacology</topic><topic>Oligopeptides - administration & dosage</topic><topic>Oligopeptides - pharmacology</topic><topic>Pyrrolidonecarboxylic Acid - analogs & derivatives</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Milde, J J</creatorcontrib><creatorcontrib>Ziegler, R</creatorcontrib><creatorcontrib>Wallstein, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of experimental biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Milde, J J</au><au>Ziegler, R</au><au>Wallstein, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adipokinetic hormone stimulates neurones in the insect central nervous system</atitle><jtitle>Journal of experimental biology</jtitle><addtitle>J Exp Biol</addtitle><date>1995-06</date><risdate>1995</risdate><volume>198</volume><issue>Pt 6</issue><spage>1307</spage><epage>1311</epage><pages>1307-1311</pages><issn>0022-0949</issn><eissn>1477-9145</eissn><coden>JEBIAM</coden><abstract>A simple preparation designed to screen and compare the central action of putative neuroactive agents in the moth Manduca sexta is described. This approach combines microinjections into the central nervous system with myograms recorded from a pair of spontaneously active mesothoracic muscles. Pressure injection of either octopamine or Manduca adipokinetic hormone (M-AKH) into the mesothoracic neuropile increases the monitored motor activity. Under the conditions used, the excitatory effects of M-AKH exceed those of the potent neuromodulator octopamine. This suggests that M-AKH plays a role in the central nervous system in addition to its known metabolic functions and supports recent evidence that neuropeptides in insects can be multifunctional.</abstract><cop>England</cop><pub>The Company of Biologists Ltd</pub><pmid>7782718</pmid><doi>10.1242/jeb.198.6.1307</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-0949 |
| ispartof | Journal of experimental biology, 1995-06, Vol.198 (Pt 6), p.1307-1311 |
| issn | 0022-0949 1477-9145 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77334984 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Company of Biologists |
| subjects | Amino Acid Sequence Animals Cellular biology Central Nervous System - drug effects Central Nervous System - physiology Hormones Insect Hormones - administration & dosage Insect Hormones - pharmacology Insects Manduca - drug effects Manduca - physiology Manduca sexta Molecular Sequence Data Nervous system Neurons Neurons - drug effects Neurons - physiology Octopamine - pharmacology Oligopeptides - administration & dosage Oligopeptides - pharmacology Pyrrolidonecarboxylic Acid - analogs & derivatives |
| title | Adipokinetic hormone stimulates neurones in the insect central nervous system |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T09%3A28%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Adipokinetic%20hormone%20stimulates%20neurones%20in%20the%20insect%20central%20nervous%20system&rft.jtitle=Journal%20of%20experimental%20biology&rft.au=Milde,%20J%20J&rft.date=1995-06&rft.volume=198&rft.issue=Pt%206&rft.spage=1307&rft.epage=1311&rft.pages=1307-1311&rft.issn=0022-0949&rft.eissn=1477-9145&rft.coden=JEBIAM&rft_id=info:doi/10.1242/jeb.198.6.1307&rft_dat=%3Cproquest_cross%3E15829856%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=230327564&rft_id=info:pmid/7782718&rfr_iscdi=true |