Intracellular Localization of 8-Oxo-dGTPase in Human Cells, with Special Reference to the Role of the Enzyme in Mitochondria

We examined the intracellular distribution of 8-oxo-dGTPase (8-oxo-7,8-dihydrodeoxyguanosine triphosphatase) encoded by the MTH1 gene, a human mutator homologue. The activity of 8-oxo-dGTPase mainly located in cytosolic and mitochondrial soluble fractions of Jurkat cells, a human T-cell leukemia lin...

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Veröffentlicht in:	The Journal of biological chemistry 1995-06, Vol.270 (24), p.14659-14665
Hauptverfasser:	Kang, Dongchon, Nishida, Jun-ichi, Iyama, Akihiro, Nakabeppu, Yusaku, Furuichi, Masato, Fujiwara, Toshiyuki, Sekiguchi, Mutsuo, Takeshige, Koichiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Blotting, Western Chromatography, Ion Exchange Cloning, Molecular DNA Repair Enzymes HeLa Cells Humans Immunohistochemistry Microscopy, Electron Mitochondria - enzymology Mitochondria - ultrastructure Phosphoric Monoester Hydrolases - genetics Phosphoric Monoester Hydrolases - isolation & purification Phosphoric Monoester Hydrolases - metabolism Subcellular Fractions - enzymology Tumor Cells, Cultured
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