No Demonstrated Effect of Pre-enucleation Irradiation on Survival of Patients With Uveal Melanoma

To evaluate the hypothetical effect of pre-enucleation irradiation on survival of patients with uveal melanoma. In a prospective study between 1978 and 1990, 145 patients with uveal melanoma were treated by irradiation in two fractions of 4 Gy before enucleation. A historical control group of 89 pat...

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Veröffentlicht in:	American journal of ophthalmology 1995-06, Vol.119 (6), p.786-791
Hauptverfasser:	LUYTEN, GREGORIUS P.M., MOOY, CORNELIA M., EIJKENBOOM, WILHELMINA M.H., STIJNEN, THEO, HELLEMONS, LAURENTIUS P., LUIDER, THEO M., DE Jong, PAULUS T.V.M.
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Sprache:	eng
Schlagworte:	Eye Enucleation Female Follow-Up Studies Humans Longitudinal Studies Male Melanoma - mortality Melanoma - radiotherapy Melanoma - surgery Middle Aged Proportional Hazards Models Prospective Studies Radiotherapy Dosage Radiotherapy, Adjuvant Survival Analysis Uveal Neoplasms - mortality Uveal Neoplasms - radiotherapy Uveal Neoplasms - surgery
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container_title	American journal of ophthalmology
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creator	LUYTEN, GREGORIUS P.M. MOOY, CORNELIA M. EIJKENBOOM, WILHELMINA M.H. STIJNEN, THEO HELLEMONS, LAURENTIUS P. LUIDER, THEO M. DE Jong, PAULUS T.V.M.
description	To evaluate the hypothetical effect of pre-enucleation irradiation on survival of patients with uveal melanoma. In a prospective study between 1978 and 1990, 145 patients with uveal melanoma were treated by irradiation in two fractions of 4 Gy before enucleation. A historical control group of 89 patients with uveal melanoma treated by enucleation alone was operated on between 1971 and 1990. Patients were followed up until December 1992 or until death. The mean follow-up period was 65 months in the irradiated group and 88 months in the control group. The preoperatively irradiated group of patients showed no significant improvement of the survival rate after 7 1/2 years (75.9%) compared with the control group (72.1%). Preoperative irradiation was not associated with survival (P = .93), as assessed by Cox proportional hazard analysis, adjusted for age, gender, tumor location, tumor size, cell type, and year of enucleation. Women in both the irradiated and control groups had a better prognosis than men (P = .002). Preoperative irradiation in this nonrandomized study had no effect on survival of patients with uveal melanoma.
doi_str_mv	10.1016/S0002-9394(14)72786-2
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In a prospective study between 1978 and 1990, 145 patients with uveal melanoma were treated by irradiation in two fractions of 4 Gy before enucleation. A historical control group of 89 patients with uveal melanoma treated by enucleation alone was operated on between 1971 and 1990. Patients were followed up until December 1992 or until death. The mean follow-up period was 65 months in the irradiated group and 88 months in the control group. The preoperatively irradiated group of patients showed no significant improvement of the survival rate after 7 1/2 years (75.9%) compared with the control group (72.1%). Preoperative irradiation was not associated with survival (P = .93), as assessed by Cox proportional hazard analysis, adjusted for age, gender, tumor location, tumor size, cell type, and year of enucleation. Women in both the irradiated and control groups had a better prognosis than men (P = .002). 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In a prospective study between 1978 and 1990, 145 patients with uveal melanoma were treated by irradiation in two fractions of 4 Gy before enucleation. A historical control group of 89 patients with uveal melanoma treated by enucleation alone was operated on between 1971 and 1990. Patients were followed up until December 1992 or until death. The mean follow-up period was 65 months in the irradiated group and 88 months in the control group. The preoperatively irradiated group of patients showed no significant improvement of the survival rate after 7 1/2 years (75.9%) compared with the control group (72.1%). Preoperative irradiation was not associated with survival (P = .93), as assessed by Cox proportional hazard analysis, adjusted for age, gender, tumor location, tumor size, cell type, and year of enucleation. Women in both the irradiated and control groups had a better prognosis than men (P = .002). Preoperative irradiation in this nonrandomized study had no effect on survival of patients with uveal melanoma.</description><subject>Eye Enucleation</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Melanoma - mortality</subject><subject>Melanoma - radiotherapy</subject><subject>Melanoma - surgery</subject><subject>Middle Aged</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>Radiotherapy Dosage</subject><subject>Radiotherapy, Adjuvant</subject><subject>Survival Analysis</subject><subject>Uveal Neoplasms - mortality</subject><subject>Uveal Neoplasms - radiotherapy</subject><subject>Uveal Neoplasms - surgery</subject><issn>0002-9394</issn><issn>1879-1891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkNtKxDAQhoMo63p4BKFXohfVJE2T5kpkXQ_gCdbFy5BtphhpG03SBd_e7AFvhYFMZv4_k_kQOiH4gmDCL2cYY5rLQrIzws4FFRXP6Q4ak0rInFSS7KLxn2QfHYTwma5cMDFCIyGqkstyjPSzy26gc32IXkcw2bRpoI6Za7JXDzn0Q92Cjtb12YP32thNnmI2-KVd6nYtTVXoY8jebfzI5ktI5Sdode86fYT2Gt0GON6eh2h-O32b3OePL3cPk-vHvKaijDmnFAMDYhqjWclqUhbVooTCGNIIrbnBmvG0QKEJ0MZIwY1khMtCY0oXRhaH6HTz7pd33wOEqDobamjTL8ANQQlRFIyQlbDcCGvvQvDQqC9vO-1_FMFqhVat0aoVN0WYWqNVNPlOtgOGRQfmz7VlmfpXmz6kLZcWvAp1olKDsT4hVcbZfyb8As53iPg</recordid><startdate>199506</startdate><enddate>199506</enddate><creator>LUYTEN, GREGORIUS P.M.</creator><creator>MOOY, CORNELIA M.</creator><creator>EIJKENBOOM, WILHELMINA M.H.</creator><creator>STIJNEN, THEO</creator><creator>HELLEMONS, LAURENTIUS P.</creator><creator>LUIDER, THEO M.</creator><creator>DE Jong, PAULUS T.V.M.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199506</creationdate><title>No Demonstrated Effect of Pre-enucleation Irradiation on Survival of Patients With Uveal Melanoma</title><author>LUYTEN, GREGORIUS P.M. ; MOOY, CORNELIA M. ; EIJKENBOOM, WILHELMINA M.H. ; STIJNEN, THEO ; HELLEMONS, LAURENTIUS P. ; LUIDER, THEO M. ; DE Jong, PAULUS T.V.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c275t-6220e4e1dfda454c1538b5e3dd1f7aa6d0a460003a1e2fd976d941693a022bd93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Eye Enucleation</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Melanoma - mortality</topic><topic>Melanoma - radiotherapy</topic><topic>Melanoma - surgery</topic><topic>Middle Aged</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>Radiotherapy Dosage</topic><topic>Radiotherapy, Adjuvant</topic><topic>Survival Analysis</topic><topic>Uveal Neoplasms - mortality</topic><topic>Uveal Neoplasms - radiotherapy</topic><topic>Uveal Neoplasms - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LUYTEN, GREGORIUS P.M.</creatorcontrib><creatorcontrib>MOOY, CORNELIA M.</creatorcontrib><creatorcontrib>EIJKENBOOM, WILHELMINA M.H.</creatorcontrib><creatorcontrib>STIJNEN, THEO</creatorcontrib><creatorcontrib>HELLEMONS, LAURENTIUS P.</creatorcontrib><creatorcontrib>LUIDER, THEO M.</creatorcontrib><creatorcontrib>DE Jong, PAULUS T.V.M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LUYTEN, GREGORIUS P.M.</au><au>MOOY, CORNELIA M.</au><au>EIJKENBOOM, WILHELMINA M.H.</au><au>STIJNEN, THEO</au><au>HELLEMONS, LAURENTIUS P.</au><au>LUIDER, THEO M.</au><au>DE Jong, PAULUS T.V.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>No Demonstrated Effect of Pre-enucleation Irradiation on Survival of Patients With Uveal Melanoma</atitle><jtitle>American journal of ophthalmology</jtitle><addtitle>Am J Ophthalmol</addtitle><date>1995-06</date><risdate>1995</risdate><volume>119</volume><issue>6</issue><spage>786</spage><epage>791</epage><pages>786-791</pages><issn>0002-9394</issn><eissn>1879-1891</eissn><abstract>To evaluate the hypothetical effect of pre-enucleation irradiation on survival of patients with uveal melanoma. In a prospective study between 1978 and 1990, 145 patients with uveal melanoma were treated by irradiation in two fractions of 4 Gy before enucleation. A historical control group of 89 patients with uveal melanoma treated by enucleation alone was operated on between 1971 and 1990. Patients were followed up until December 1992 or until death. The mean follow-up period was 65 months in the irradiated group and 88 months in the control group. The preoperatively irradiated group of patients showed no significant improvement of the survival rate after 7 1/2 years (75.9%) compared with the control group (72.1%). Preoperative irradiation was not associated with survival (P = .93), as assessed by Cox proportional hazard analysis, adjusted for age, gender, tumor location, tumor size, cell type, and year of enucleation. Women in both the irradiated and control groups had a better prognosis than men (P = .002). Preoperative irradiation in this nonrandomized study had no effect on survival of patients with uveal melanoma.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>7785695</pmid><doi>10.1016/S0002-9394(14)72786-2</doi><tpages>6</tpages></addata></record>
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subjects	Eye Enucleation Female Follow-Up Studies Humans Longitudinal Studies Male Melanoma - mortality Melanoma - radiotherapy Melanoma - surgery Middle Aged Proportional Hazards Models Prospective Studies Radiotherapy Dosage Radiotherapy, Adjuvant Survival Analysis Uveal Neoplasms - mortality Uveal Neoplasms - radiotherapy Uveal Neoplasms - surgery
title	No Demonstrated Effect of Pre-enucleation Irradiation on Survival of Patients With Uveal Melanoma
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