A COMPARATIVE STUDY OF TAZOBACTAM/PIPERACILLIN AND PIPERACILLIN IN BACTERIAL PNEUMONIA
The efficacy, safety and usefulness of tazobactam/piperacillin (TAZ/PIPC), in bacterial pneumonia and lung abscess were determined with PIPC as the control in a multi-institutional comparative study a penicillin antibiotic for injection prepared by combining a newly developed β-lactamase inhibitor,...
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| Veröffentlicht in: | Japanese journal of antibiotics 1995/04/25, Vol.48(4), pp.449-481 |
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| creator | OIZUMI, KOTARO KAWAHARA, MASAO SAISHO, MASAZUMI MITUTAKE, YOSHIYUKI SAITO, AKIRA TAMURA, TOYOKAZU KONISHI, KAZUKI KATOH, SAKURA TAKEUCHI, KENICHI OHARA, AKIHO IKEDA, HIDEKI SIRATO, KUNIO TANNO, YASUO TOHNO, MASATO ONO, YASUO SUZUKI, TAKUYA NUKIWA, TOSHIHIRO KONNO, KIYOSHI SAYAMA, TSUNEO SATO, KAZUO YOSHIDA, SUSUMU KANEKO, KOHTARO SHIMADA, KAORU AKIYAMA, NORIHISA NAKADA, KOICHIRO NAKATANI, TATSUO TYONABAYASHI, NAOHIKO KUDO, KOICHIRO ARIOKA, HIROKO SHISHIDO, HARUMI TAKAHASHI, ATSUSHI KATAYAMA, HIROFUMI BABA, MOTOO KOYAMA, MASARU MURABAYASHI, KOHJI SHIMADA, JINGORO IRIMAJIRI, SHOICHIRO MATSUOKA, YASUO OBANA, MITSUO ODAGIRI, SHIGEKI HOSHINO, SHIGEYUKI TSUKADA, HIROKI AOKI, NOBUKI IZUMI, SABURO NAKANO, YUTAKA NODA, YASUNOBU GONDA, HIDEO HANAKI, HIDEKAZU KAWAKAMI, MAKOTO SUZUKI, KANZO KUZE, FUMIYUKI BANDO, KENJI KUSAKA, SHOHEI ISHIDA, TADASHI MOCHIZUKI, YOSHIRO TSUYUGUCHI, KAZUSHIGE YASUNAGA, KOJIRO YONEZU, SEIBUN YAMANAKA, YOSHITAKA NARITA, NOBUHIRO MIKASA, KEIICHI HIGASHINO, KAZUYA NISHIGAKI, TETSUYA GOTO, YUMIKO SUGIMOTO, HIROSHI SOEJIMA, RINZO MORIYA, OSAMU SHINDO, AKIHISA MATSUSHIMA, TOSHIHARU YAMAKIDO, MICHIO HASEGAWA, KENJI KURIMURA, OSAMU HIGUCHI, MASANORI OHYAMA, TAKAOKI FURUUMI, KATSUHIKO ISHIBASHI, TSUNEO TAKAMOTO, MASAHIRO HARADA, YASUKO HARADA, SUSUMU HARA, KOHEI KOGA, HIRONOBU RI, YOSHIAKI MASUYAMA, TAIJI YOSHIMOTO, MASAHIKO SHIMOGUCHI, KAZUNORI OKUNO, KAZUHIRO FUKUSHIMA, KIYOYASU NAGATAKE, TSUYOSHI HORI, AKIHIRO ANDO, MASAYUKI SUGA, MORITAKA SAITA, NAOKI YAMASAKI, TOHRU GOTO, JUN KITAGAWA, KAZUO SAITO, ATSUSHI OWAN, ISOKO INADOME, JUN OGAWA, NOBUYA DEGUCHI, KOICHI |
| description | The efficacy, safety and usefulness of tazobactam/piperacillin (TAZ/PIPC), in bacterial pneumonia and lung abscess were determined with PIPC as the control in a multi-institutional comparative study a penicillin antibiotic for injection prepared by combining a newly developed β-lactamase inhibitor, tazobactam (TAZ), with a broad spectrum penicillin antibiotic, piperacillin (PIPC), at a ratio of 1: 4. TAZ/PIPC was intravenously injected at a dose of 2.5 g (titer) twice a day, and PIPC at a dose of 2.0 g (titer) twice a day as a rule for 14 days. The following results were obtained: 1. The efficacy rates for bacterial pneumonia and lung abscess were 94% (80/85) in TAZ/PIPC group and 89% (70/79) in PIPC group, showing no significant difference between the twogroups. 2. In a comparison of degrees of improvement in clinical symptoms, signs and laboratory findings, there were no significant differences between the two groups except for results on thoracic rales after three days of administration. 3. As for bacteriological effects, the elimination rates of causative organisms were 98% (40/41) in the TAZ/PIPC group and 80% (28/35) in the PIPC group. Thus, the TAZ/PIPC group was significantly superior to the PIPC group. The TAZ/PIPC group showed significantly better eradication of bacateria as well. Bacteria considered to be pyogenic were detected in 80 patients (43 administered TAZ/PIPC and 37 administered PIPC), but β-lactamase production was confirmed in only 11 patients of each group. There were no significant differences in bacteriological effects among these patients. Minimum inhibitory concentrations of TAZ/PIPC against β-lactamase producing organisms were distinctly superior to those of PIPC. 4. Side effects occurred in 10% (10/96) of the TAZ/PIPC group and 7% (7/95) of the PIPC group. Abnormal clinical laboratory test values were observed in 22% (20/92) of the TAZ/PIPC group and 18% (17/93) of the PIPC group. Thus, there were no significant differences between the two administration groups. 5. The usefulness rate in the TAZ/PIPC group was 87% (75/86) and it was 85% (67/79) in the PIPC group, showing no significant difference between them. The results suggest that TAZ/PIPC administered at a dose of 2.5 g (titer) twice a day is more useful than PIPC administered at a dose of 2.0g (titer) twice a day in the treatment of bacterial pneumonia. |
| doi_str_mv | 10.11553/antibiotics1968b.48.449 |
| format | Article |
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KAWAHARA, MASAO ; SAISHO, MASAZUMI ; MITUTAKE, YOSHIYUKI ; SAITO, AKIRA ; TAMURA, TOYOKAZU ; KONISHI, KAZUKI ; KATOH, SAKURA ; TAKEUCHI, KENICHI ; OHARA, AKIHO ; IKEDA, HIDEKI ; SIRATO, KUNIO ; TANNO, YASUO ; TOHNO, MASATO ; ONO, YASUO ; SUZUKI, TAKUYA ; NUKIWA, TOSHIHIRO ; KONNO, KIYOSHI ; SAYAMA, TSUNEO ; SATO, KAZUO ; YOSHIDA, SUSUMU ; KANEKO, KOHTARO ; SHIMADA, KAORU ; AKIYAMA, NORIHISA ; NAKADA, KOICHIRO ; NAKATANI, TATSUO ; TYONABAYASHI, NAOHIKO ; KUDO, KOICHIRO ; ARIOKA, HIROKO ; SHISHIDO, HARUMI ; TAKAHASHI, ATSUSHI ; KATAYAMA, HIROFUMI ; BABA, MOTOO ; KOYAMA, MASARU ; MURABAYASHI, KOHJI ; SHIMADA, JINGORO ; IRIMAJIRI, SHOICHIRO ; MATSUOKA, YASUO ; OBANA, MITSUO ; ODAGIRI, SHIGEKI ; HOSHINO, SHIGEYUKI ; TSUKADA, HIROKI ; AOKI, NOBUKI ; IZUMI, SABURO ; NAKANO, YUTAKA ; NODA, YASUNOBU ; GONDA, HIDEO ; HANAKI, HIDEKAZU ; KAWAKAMI, MAKOTO ; SUZUKI, KANZO ; KUZE, FUMIYUKI ; BANDO, KENJI ; KUSAKA, SHOHEI ; ISHIDA, TADASHI ; MOCHIZUKI, YOSHIRO ; TSUYUGUCHI, KAZUSHIGE ; YASUNAGA, KOJIRO ; 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TANNO, YASUO ; TOHNO, MASATO ; ONO, YASUO ; SUZUKI, TAKUYA ; NUKIWA, TOSHIHIRO ; KONNO, KIYOSHI ; SAYAMA, TSUNEO ; SATO, KAZUO ; YOSHIDA, SUSUMU ; KANEKO, KOHTARO ; SHIMADA, KAORU ; AKIYAMA, NORIHISA ; NAKADA, KOICHIRO ; NAKATANI, TATSUO ; TYONABAYASHI, NAOHIKO ; KUDO, KOICHIRO ; ARIOKA, HIROKO ; SHISHIDO, HARUMI ; TAKAHASHI, ATSUSHI ; KATAYAMA, HIROFUMI ; BABA, MOTOO ; KOYAMA, MASARU ; MURABAYASHI, KOHJI ; SHIMADA, JINGORO ; IRIMAJIRI, SHOICHIRO ; MATSUOKA, YASUO ; OBANA, MITSUO ; ODAGIRI, SHIGEKI ; HOSHINO, SHIGEYUKI ; TSUKADA, HIROKI ; AOKI, NOBUKI ; IZUMI, SABURO ; NAKANO, YUTAKA ; NODA, YASUNOBU ; GONDA, HIDEO ; HANAKI, HIDEKAZU ; KAWAKAMI, MAKOTO ; SUZUKI, KANZO ; KUZE, FUMIYUKI ; BANDO, KENJI ; KUSAKA, SHOHEI ; ISHIDA, TADASHI ; MOCHIZUKI, YOSHIRO ; TSUYUGUCHI, KAZUSHIGE ; YASUNAGA, KOJIRO ; YONEZU, SEIBUN ; YAMANAKA, YOSHITAKA ; NARITA, NOBUHIRO ; MIKASA, KEIICHI ; HIGASHINO, KAZUYA ; NISHIGAKI, TETSUYA ; GOTO, YUMIKO ; SUGIMOTO, HIROSHI ; SOEJIMA, RINZO ; MORIYA, OSAMU ; SHINDO, AKIHISA ; MATSUSHIMA, TOSHIHARU ; YAMAKIDO, MICHIO ; HASEGAWA, KENJI ; KURIMURA, OSAMU ; HIGUCHI, MASANORI ; OHYAMA, TAKAOKI ; FURUUMI, KATSUHIKO ; ISHIBASHI, TSUNEO ; TAKAMOTO, MASAHIRO ; HARADA, YASUKO ; HARADA, SUSUMU ; HARA, KOHEI ; KOGA, HIRONOBU ; RI, YOSHIAKI ; MASUYAMA, TAIJI ; YOSHIMOTO, MASAHIKO ; SHIMOGUCHI, KAZUNORI ; OKUNO, KAZUHIRO ; FUKUSHIMA, KIYOYASU ; NAGATAKE, TSUYOSHI ; HORI, AKIHIRO ; ANDO, MASAYUKI ; SUGA, MORITAKA ; SAITA, NAOKI ; YAMASAKI, TOHRU ; GOTO, JUN ; KITAGAWA, KAZUO ; SAITO, ATSUSHI ; OWAN, ISOKO ; INADOME, JUN ; OGAWA, NOBUYA ; DEGUCHI, KOICHI</creatorcontrib><description>The efficacy, safety and usefulness of tazobactam/piperacillin (TAZ/PIPC), in bacterial pneumonia and lung abscess were determined with PIPC as the control in a multi-institutional comparative study a penicillin antibiotic for injection prepared by combining a newly developed β-lactamase inhibitor, tazobactam (TAZ), with a broad spectrum penicillin antibiotic, piperacillin (PIPC), at a ratio of 1: 4. TAZ/PIPC was intravenously injected at a dose of 2.5 g (titer) twice a day, and PIPC at a dose of 2.0 g (titer) twice a day as a rule for 14 days. The following results were obtained: 1. The efficacy rates for bacterial pneumonia and lung abscess were 94% (80/85) in TAZ/PIPC group and 89% (70/79) in PIPC group, showing no significant difference between the twogroups. 2. In a comparison of degrees of improvement in clinical symptoms, signs and laboratory findings, there were no significant differences between the two groups except for results on thoracic rales after three days of administration. 3. As for bacteriological effects, the elimination rates of causative organisms were 98% (40/41) in the TAZ/PIPC group and 80% (28/35) in the PIPC group. Thus, the TAZ/PIPC group was significantly superior to the PIPC group. The TAZ/PIPC group showed significantly better eradication of bacateria as well. Bacteria considered to be pyogenic were detected in 80 patients (43 administered TAZ/PIPC and 37 administered PIPC), but β-lactamase production was confirmed in only 11 patients of each group. There were no significant differences in bacteriological effects among these patients. Minimum inhibitory concentrations of TAZ/PIPC against β-lactamase producing organisms were distinctly superior to those of PIPC. 4. Side effects occurred in 10% (10/96) of the TAZ/PIPC group and 7% (7/95) of the PIPC group. Abnormal clinical laboratory test values were observed in 22% (20/92) of the TAZ/PIPC group and 18% (17/93) of the PIPC group. Thus, there were no significant differences between the two administration groups. 5. The usefulness rate in the TAZ/PIPC group was 87% (75/86) and it was 85% (67/79) in the PIPC group, showing no significant difference between them. The results suggest that TAZ/PIPC administered at a dose of 2.5 g (titer) twice a day is more useful than PIPC administered at a dose of 2.0g (titer) twice a day in the treatment of bacterial pneumonia.</description><identifier>ISSN: 0368-2781</identifier><identifier>EISSN: 2186-5477</identifier><identifier>DOI: 10.11553/antibiotics1968b.48.449</identifier><identifier>PMID: 7783313</identifier><language>jpn</language><publisher>Japan: Japan Antibiotics Research Association</publisher><subject>Adult ; Aged ; Aged, 80 and over ; beta-Lactamase Inhibitors ; Drug Administration Schedule ; Drug Combinations ; Female ; Humans ; Injections, Intravenous ; Lung Abscess - drug therapy ; Lung Abscess - microbiology ; Male ; Middle Aged ; Penicillanic Acid - administration & dosage ; Penicillanic Acid - analogs & derivatives ; Piperacillin - administration & dosage ; Piperacillin - therapeutic use ; Pneumonia, Bacterial - drug therapy ; Pneumonia, Bacterial - microbiology</subject><ispartof>The Japanese Journal of Antibiotics, 1995/04/25, Vol.48(4), pp.449-481</ispartof><rights>Japan Antibiotics Research Association</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7783313$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>OIZUMI, KOTARO</creatorcontrib><creatorcontrib>KAWAHARA, MASAO</creatorcontrib><creatorcontrib>SAISHO, MASAZUMI</creatorcontrib><creatorcontrib>MITUTAKE, YOSHIYUKI</creatorcontrib><creatorcontrib>SAITO, AKIRA</creatorcontrib><creatorcontrib>TAMURA, TOYOKAZU</creatorcontrib><creatorcontrib>KONISHI, KAZUKI</creatorcontrib><creatorcontrib>KATOH, SAKURA</creatorcontrib><creatorcontrib>TAKEUCHI, KENICHI</creatorcontrib><creatorcontrib>OHARA, AKIHO</creatorcontrib><creatorcontrib>IKEDA, HIDEKI</creatorcontrib><creatorcontrib>SIRATO, KUNIO</creatorcontrib><creatorcontrib>TANNO, YASUO</creatorcontrib><creatorcontrib>TOHNO, MASATO</creatorcontrib><creatorcontrib>ONO, YASUO</creatorcontrib><creatorcontrib>SUZUKI, TAKUYA</creatorcontrib><creatorcontrib>NUKIWA, TOSHIHIRO</creatorcontrib><creatorcontrib>KONNO, KIYOSHI</creatorcontrib><creatorcontrib>SAYAMA, TSUNEO</creatorcontrib><creatorcontrib>SATO, KAZUO</creatorcontrib><creatorcontrib>YOSHIDA, SUSUMU</creatorcontrib><creatorcontrib>KANEKO, KOHTARO</creatorcontrib><creatorcontrib>SHIMADA, KAORU</creatorcontrib><creatorcontrib>AKIYAMA, NORIHISA</creatorcontrib><creatorcontrib>NAKADA, KOICHIRO</creatorcontrib><creatorcontrib>NAKATANI, TATSUO</creatorcontrib><creatorcontrib>TYONABAYASHI, NAOHIKO</creatorcontrib><creatorcontrib>KUDO, KOICHIRO</creatorcontrib><creatorcontrib>ARIOKA, HIROKO</creatorcontrib><creatorcontrib>SHISHIDO, HARUMI</creatorcontrib><creatorcontrib>TAKAHASHI, ATSUSHI</creatorcontrib><creatorcontrib>KATAYAMA, HIROFUMI</creatorcontrib><creatorcontrib>BABA, MOTOO</creatorcontrib><creatorcontrib>KOYAMA, MASARU</creatorcontrib><creatorcontrib>MURABAYASHI, KOHJI</creatorcontrib><creatorcontrib>SHIMADA, JINGORO</creatorcontrib><creatorcontrib>IRIMAJIRI, SHOICHIRO</creatorcontrib><creatorcontrib>MATSUOKA, YASUO</creatorcontrib><creatorcontrib>OBANA, MITSUO</creatorcontrib><creatorcontrib>ODAGIRI, SHIGEKI</creatorcontrib><creatorcontrib>HOSHINO, SHIGEYUKI</creatorcontrib><creatorcontrib>TSUKADA, HIROKI</creatorcontrib><creatorcontrib>AOKI, NOBUKI</creatorcontrib><creatorcontrib>IZUMI, SABURO</creatorcontrib><creatorcontrib>NAKANO, YUTAKA</creatorcontrib><creatorcontrib>NODA, YASUNOBU</creatorcontrib><creatorcontrib>GONDA, HIDEO</creatorcontrib><creatorcontrib>HANAKI, HIDEKAZU</creatorcontrib><creatorcontrib>KAWAKAMI, MAKOTO</creatorcontrib><creatorcontrib>SUZUKI, KANZO</creatorcontrib><creatorcontrib>KUZE, FUMIYUKI</creatorcontrib><creatorcontrib>BANDO, KENJI</creatorcontrib><creatorcontrib>KUSAKA, SHOHEI</creatorcontrib><creatorcontrib>ISHIDA, TADASHI</creatorcontrib><creatorcontrib>MOCHIZUKI, YOSHIRO</creatorcontrib><creatorcontrib>TSUYUGUCHI, KAZUSHIGE</creatorcontrib><creatorcontrib>YASUNAGA, KOJIRO</creatorcontrib><creatorcontrib>YONEZU, SEIBUN</creatorcontrib><creatorcontrib>YAMANAKA, YOSHITAKA</creatorcontrib><creatorcontrib>NARITA, NOBUHIRO</creatorcontrib><creatorcontrib>MIKASA, KEIICHI</creatorcontrib><creatorcontrib>HIGASHINO, KAZUYA</creatorcontrib><creatorcontrib>NISHIGAKI, TETSUYA</creatorcontrib><creatorcontrib>GOTO, YUMIKO</creatorcontrib><creatorcontrib>SUGIMOTO, HIROSHI</creatorcontrib><creatorcontrib>SOEJIMA, RINZO</creatorcontrib><creatorcontrib>MORIYA, OSAMU</creatorcontrib><creatorcontrib>SHINDO, AKIHISA</creatorcontrib><creatorcontrib>MATSUSHIMA, TOSHIHARU</creatorcontrib><creatorcontrib>YAMAKIDO, MICHIO</creatorcontrib><creatorcontrib>HASEGAWA, KENJI</creatorcontrib><creatorcontrib>KURIMURA, OSAMU</creatorcontrib><creatorcontrib>HIGUCHI, MASANORI</creatorcontrib><creatorcontrib>OHYAMA, TAKAOKI</creatorcontrib><creatorcontrib>FURUUMI, KATSUHIKO</creatorcontrib><creatorcontrib>ISHIBASHI, TSUNEO</creatorcontrib><creatorcontrib>TAKAMOTO, MASAHIRO</creatorcontrib><creatorcontrib>HARADA, YASUKO</creatorcontrib><creatorcontrib>HARADA, SUSUMU</creatorcontrib><creatorcontrib>HARA, KOHEI</creatorcontrib><creatorcontrib>KOGA, HIRONOBU</creatorcontrib><creatorcontrib>RI, YOSHIAKI</creatorcontrib><creatorcontrib>MASUYAMA, TAIJI</creatorcontrib><creatorcontrib>YOSHIMOTO, MASAHIKO</creatorcontrib><creatorcontrib>SHIMOGUCHI, KAZUNORI</creatorcontrib><creatorcontrib>OKUNO, KAZUHIRO</creatorcontrib><creatorcontrib>FUKUSHIMA, KIYOYASU</creatorcontrib><creatorcontrib>NAGATAKE, TSUYOSHI</creatorcontrib><creatorcontrib>HORI, AKIHIRO</creatorcontrib><creatorcontrib>ANDO, MASAYUKI</creatorcontrib><creatorcontrib>SUGA, MORITAKA</creatorcontrib><creatorcontrib>SAITA, NAOKI</creatorcontrib><creatorcontrib>YAMASAKI, TOHRU</creatorcontrib><creatorcontrib>GOTO, JUN</creatorcontrib><creatorcontrib>KITAGAWA, KAZUO</creatorcontrib><creatorcontrib>SAITO, ATSUSHI</creatorcontrib><creatorcontrib>OWAN, ISOKO</creatorcontrib><creatorcontrib>INADOME, JUN</creatorcontrib><creatorcontrib>OGAWA, NOBUYA</creatorcontrib><creatorcontrib>DEGUCHI, KOICHI</creatorcontrib><title>A COMPARATIVE STUDY OF TAZOBACTAM/PIPERACILLIN AND PIPERACILLIN IN BACTERIAL PNEUMONIA</title><title>Japanese journal of antibiotics</title><addtitle>Jpn. J. Antibiotics</addtitle><description>The efficacy, safety and usefulness of tazobactam/piperacillin (TAZ/PIPC), in bacterial pneumonia and lung abscess were determined with PIPC as the control in a multi-institutional comparative study a penicillin antibiotic for injection prepared by combining a newly developed β-lactamase inhibitor, tazobactam (TAZ), with a broad spectrum penicillin antibiotic, piperacillin (PIPC), at a ratio of 1: 4. TAZ/PIPC was intravenously injected at a dose of 2.5 g (titer) twice a day, and PIPC at a dose of 2.0 g (titer) twice a day as a rule for 14 days. The following results were obtained: 1. The efficacy rates for bacterial pneumonia and lung abscess were 94% (80/85) in TAZ/PIPC group and 89% (70/79) in PIPC group, showing no significant difference between the twogroups. 2. In a comparison of degrees of improvement in clinical symptoms, signs and laboratory findings, there were no significant differences between the two groups except for results on thoracic rales after three days of administration. 3. As for bacteriological effects, the elimination rates of causative organisms were 98% (40/41) in the TAZ/PIPC group and 80% (28/35) in the PIPC group. Thus, the TAZ/PIPC group was significantly superior to the PIPC group. The TAZ/PIPC group showed significantly better eradication of bacateria as well. Bacteria considered to be pyogenic were detected in 80 patients (43 administered TAZ/PIPC and 37 administered PIPC), but β-lactamase production was confirmed in only 11 patients of each group. There were no significant differences in bacteriological effects among these patients. Minimum inhibitory concentrations of TAZ/PIPC against β-lactamase producing organisms were distinctly superior to those of PIPC. 4. Side effects occurred in 10% (10/96) of the TAZ/PIPC group and 7% (7/95) of the PIPC group. Abnormal clinical laboratory test values were observed in 22% (20/92) of the TAZ/PIPC group and 18% (17/93) of the PIPC group. Thus, there were no significant differences between the two administration groups. 5. The usefulness rate in the TAZ/PIPC group was 87% (75/86) and it was 85% (67/79) in the PIPC group, showing no significant difference between them. The results suggest that TAZ/PIPC administered at a dose of 2.5 g (titer) twice a day is more useful than PIPC administered at a dose of 2.0g (titer) twice a day in the treatment of bacterial pneumonia.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>beta-Lactamase Inhibitors</subject><subject>Drug Administration Schedule</subject><subject>Drug Combinations</subject><subject>Female</subject><subject>Humans</subject><subject>Injections, Intravenous</subject><subject>Lung Abscess - drug therapy</subject><subject>Lung Abscess - microbiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Penicillanic Acid - administration & dosage</subject><subject>Penicillanic Acid - analogs & derivatives</subject><subject>Piperacillin - administration & dosage</subject><subject>Piperacillin - therapeutic use</subject><subject>Pneumonia, Bacterial - drug therapy</subject><subject>Pneumonia, Bacterial - microbiology</subject><issn>0368-2781</issn><issn>2186-5477</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkF9LwzAUxYMoc8x9BCFPvnVrmrRJH2PttNK1ZXYDfQlpm2pH98eme_DbG90YKFzuhXN-XO49AEBkTxByXTyV274pml3flBr5HismhE0I8S_A0EHMs1xC6SUY2thjlkMZugZjrZvCxogyx2wYgAGlDGOEh2DFYZDOM77gebQK4Uu-fHiF6Qzm_C2950HO59MsysIFD6I4jhLIkwf4RzD1w4WLiMcwS8LlPE0ifgOuatlqNT7NEVjOwjx4suL0MQp4bK0RY73l2j6uVU2xZIiWfmmOqggubc9jhGLlla6DibSVkRmTsvIrVUlUE0zroqZ1jUfg7rh33-0-D0r3YtPoUrWt3KrdQQtKsfmT-ga8PYGHYqMqse-ajey-xCkI4z8f_bXu5bs6-7IzKbdK_I9cECbIbyP-GSo_ZCfUFn8DVvR38w</recordid><startdate>199504</startdate><enddate>199504</enddate><creator>OIZUMI, KOTARO</creator><creator>KAWAHARA, MASAO</creator><creator>SAISHO, MASAZUMI</creator><creator>MITUTAKE, YOSHIYUKI</creator><creator>SAITO, AKIRA</creator><creator>TAMURA, TOYOKAZU</creator><creator>KONISHI, KAZUKI</creator><creator>KATOH, 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RINZO</creator><creator>MORIYA, OSAMU</creator><creator>SHINDO, AKIHISA</creator><creator>MATSUSHIMA, TOSHIHARU</creator><creator>YAMAKIDO, MICHIO</creator><creator>HASEGAWA, KENJI</creator><creator>KURIMURA, OSAMU</creator><creator>HIGUCHI, MASANORI</creator><creator>OHYAMA, TAKAOKI</creator><creator>FURUUMI, KATSUHIKO</creator><creator>ISHIBASHI, TSUNEO</creator><creator>TAKAMOTO, MASAHIRO</creator><creator>HARADA, YASUKO</creator><creator>HARADA, SUSUMU</creator><creator>HARA, KOHEI</creator><creator>KOGA, HIRONOBU</creator><creator>RI, YOSHIAKI</creator><creator>MASUYAMA, TAIJI</creator><creator>YOSHIMOTO, MASAHIKO</creator><creator>SHIMOGUCHI, KAZUNORI</creator><creator>OKUNO, KAZUHIRO</creator><creator>FUKUSHIMA, KIYOYASU</creator><creator>NAGATAKE, TSUYOSHI</creator><creator>HORI, AKIHIRO</creator><creator>ANDO, MASAYUKI</creator><creator>SUGA, MORITAKA</creator><creator>SAITA, NAOKI</creator><creator>YAMASAKI, TOHRU</creator><creator>GOTO, JUN</creator><creator>KITAGAWA, KAZUO</creator><creator>SAITO, ATSUSHI</creator><creator>OWAN, ISOKO</creator><creator>INADOME, JUN</creator><creator>OGAWA, NOBUYA</creator><creator>DEGUCHI, KOICHI</creator><general>Japan Antibiotics Research Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199504</creationdate><title>A COMPARATIVE STUDY OF TAZOBACTAM/PIPERACILLIN AND PIPERACILLIN IN BACTERIAL PNEUMONIA</title><author>OIZUMI, KOTARO ; KAWAHARA, MASAO ; SAISHO, MASAZUMI ; MITUTAKE, YOSHIYUKI ; SAITO, AKIRA ; TAMURA, TOYOKAZU ; KONISHI, KAZUKI ; KATOH, SAKURA ; TAKEUCHI, KENICHI ; OHARA, AKIHO ; IKEDA, HIDEKI ; SIRATO, KUNIO ; TANNO, YASUO ; TOHNO, MASATO ; ONO, YASUO ; SUZUKI, TAKUYA ; NUKIWA, TOSHIHIRO ; KONNO, KIYOSHI ; SAYAMA, TSUNEO ; SATO, KAZUO ; YOSHIDA, SUSUMU ; KANEKO, KOHTARO ; SHIMADA, KAORU ; AKIYAMA, NORIHISA ; NAKADA, KOICHIRO ; NAKATANI, TATSUO ; TYONABAYASHI, NAOHIKO ; KUDO, KOICHIRO ; ARIOKA, HIROKO ; SHISHIDO, HARUMI ; TAKAHASHI, ATSUSHI ; KATAYAMA, HIROFUMI ; BABA, MOTOO ; KOYAMA, MASARU ; MURABAYASHI, KOHJI ; SHIMADA, JINGORO ; IRIMAJIRI, SHOICHIRO ; MATSUOKA, YASUO ; OBANA, MITSUO ; ODAGIRI, SHIGEKI ; HOSHINO, SHIGEYUKI ; TSUKADA, HIROKI ; AOKI, NOBUKI ; IZUMI, SABURO ; NAKANO, YUTAKA ; NODA, YASUNOBU ; GONDA, HIDEO ; HANAKI, HIDEKAZU ; KAWAKAMI, MAKOTO ; SUZUKI, KANZO ; KUZE, FUMIYUKI ; BANDO, KENJI ; KUSAKA, SHOHEI ; ISHIDA, TADASHI ; MOCHIZUKI, YOSHIRO ; TSUYUGUCHI, KAZUSHIGE ; YASUNAGA, KOJIRO ; YONEZU, SEIBUN ; YAMANAKA, YOSHITAKA ; NARITA, NOBUHIRO ; MIKASA, KEIICHI ; HIGASHINO, KAZUYA ; NISHIGAKI, TETSUYA ; GOTO, YUMIKO ; SUGIMOTO, HIROSHI ; SOEJIMA, RINZO ; MORIYA, OSAMU ; SHINDO, AKIHISA ; MATSUSHIMA, TOSHIHARU ; YAMAKIDO, MICHIO ; HASEGAWA, KENJI ; KURIMURA, OSAMU ; HIGUCHI, MASANORI ; OHYAMA, TAKAOKI ; FURUUMI, KATSUHIKO ; ISHIBASHI, TSUNEO ; TAKAMOTO, MASAHIRO ; HARADA, YASUKO ; HARADA, SUSUMU ; HARA, KOHEI ; KOGA, HIRONOBU ; RI, YOSHIAKI ; MASUYAMA, TAIJI ; YOSHIMOTO, MASAHIKO ; SHIMOGUCHI, KAZUNORI ; OKUNO, KAZUHIRO ; FUKUSHIMA, KIYOYASU ; NAGATAKE, TSUYOSHI ; HORI, AKIHIRO ; ANDO, MASAYUKI ; SUGA, MORITAKA ; SAITA, NAOKI ; YAMASAKI, TOHRU ; GOTO, JUN ; KITAGAWA, KAZUO ; SAITO, ATSUSHI ; OWAN, ISOKO ; INADOME, JUN ; OGAWA, NOBUYA ; DEGUCHI, KOICHI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j188t-5093fef73a817c9c833d43c0668473e6c5234a0e33d88aad9deda1f437fbf7ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>jpn</language><creationdate>1995</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>beta-Lactamase Inhibitors</topic><topic>Drug Administration Schedule</topic><topic>Drug Combinations</topic><topic>Female</topic><topic>Humans</topic><topic>Injections, Intravenous</topic><topic>Lung Abscess - drug therapy</topic><topic>Lung Abscess - microbiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Penicillanic Acid - administration & dosage</topic><topic>Penicillanic Acid - analogs & derivatives</topic><topic>Piperacillin - administration & dosage</topic><topic>Piperacillin - therapeutic use</topic><topic>Pneumonia, Bacterial - drug therapy</topic><topic>Pneumonia, Bacterial - microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>OIZUMI, KOTARO</creatorcontrib><creatorcontrib>KAWAHARA, MASAO</creatorcontrib><creatorcontrib>SAISHO, MASAZUMI</creatorcontrib><creatorcontrib>MITUTAKE, YOSHIYUKI</creatorcontrib><creatorcontrib>SAITO, AKIRA</creatorcontrib><creatorcontrib>TAMURA, TOYOKAZU</creatorcontrib><creatorcontrib>KONISHI, KAZUKI</creatorcontrib><creatorcontrib>KATOH, SAKURA</creatorcontrib><creatorcontrib>TAKEUCHI, KENICHI</creatorcontrib><creatorcontrib>OHARA, AKIHO</creatorcontrib><creatorcontrib>IKEDA, HIDEKI</creatorcontrib><creatorcontrib>SIRATO, KUNIO</creatorcontrib><creatorcontrib>TANNO, 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JUN</creatorcontrib><creatorcontrib>KITAGAWA, KAZUO</creatorcontrib><creatorcontrib>SAITO, ATSUSHI</creatorcontrib><creatorcontrib>OWAN, ISOKO</creatorcontrib><creatorcontrib>INADOME, JUN</creatorcontrib><creatorcontrib>OGAWA, NOBUYA</creatorcontrib><creatorcontrib>DEGUCHI, KOICHI</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>OIZUMI, KOTARO</au><au>KAWAHARA, MASAO</au><au>SAISHO, MASAZUMI</au><au>MITUTAKE, YOSHIYUKI</au><au>SAITO, AKIRA</au><au>TAMURA, TOYOKAZU</au><au>KONISHI, KAZUKI</au><au>KATOH, SAKURA</au><au>TAKEUCHI, KENICHI</au><au>OHARA, AKIHO</au><au>IKEDA, HIDEKI</au><au>SIRATO, KUNIO</au><au>TANNO, YASUO</au><au>TOHNO, MASATO</au><au>ONO, YASUO</au><au>SUZUKI, TAKUYA</au><au>NUKIWA, TOSHIHIRO</au><au>KONNO, KIYOSHI</au><au>SAYAMA, TSUNEO</au><au>SATO, KAZUO</au><au>YOSHIDA, SUSUMU</au><au>KANEKO, KOHTARO</au><au>SHIMADA, KAORU</au><au>AKIYAMA, NORIHISA</au><au>NAKADA, KOICHIRO</au><au>NAKATANI, TATSUO</au><au>TYONABAYASHI, NAOHIKO</au><au>KUDO, KOICHIRO</au><au>ARIOKA, HIROKO</au><au>SHISHIDO, HARUMI</au><au>TAKAHASHI, ATSUSHI</au><au>KATAYAMA, HIROFUMI</au><au>BABA, MOTOO</au><au>KOYAMA, MASARU</au><au>MURABAYASHI, KOHJI</au><au>SHIMADA, JINGORO</au><au>IRIMAJIRI, SHOICHIRO</au><au>MATSUOKA, YASUO</au><au>OBANA, MITSUO</au><au>ODAGIRI, SHIGEKI</au><au>HOSHINO, SHIGEYUKI</au><au>TSUKADA, HIROKI</au><au>AOKI, NOBUKI</au><au>IZUMI, SABURO</au><au>NAKANO, YUTAKA</au><au>NODA, YASUNOBU</au><au>GONDA, HIDEO</au><au>HANAKI, HIDEKAZU</au><au>KAWAKAMI, MAKOTO</au><au>SUZUKI, KANZO</au><au>KUZE, FUMIYUKI</au><au>BANDO, KENJI</au><au>KUSAKA, SHOHEI</au><au>ISHIDA, TADASHI</au><au>MOCHIZUKI, YOSHIRO</au><au>TSUYUGUCHI, KAZUSHIGE</au><au>YASUNAGA, KOJIRO</au><au>YONEZU, SEIBUN</au><au>YAMANAKA, YOSHITAKA</au><au>NARITA, NOBUHIRO</au><au>MIKASA, KEIICHI</au><au>HIGASHINO, KAZUYA</au><au>NISHIGAKI, TETSUYA</au><au>GOTO, YUMIKO</au><au>SUGIMOTO, HIROSHI</au><au>SOEJIMA, RINZO</au><au>MORIYA, OSAMU</au><au>SHINDO, AKIHISA</au><au>MATSUSHIMA, TOSHIHARU</au><au>YAMAKIDO, MICHIO</au><au>HASEGAWA, KENJI</au><au>KURIMURA, OSAMU</au><au>HIGUCHI, MASANORI</au><au>OHYAMA, TAKAOKI</au><au>FURUUMI, KATSUHIKO</au><au>ISHIBASHI, TSUNEO</au><au>TAKAMOTO, MASAHIRO</au><au>HARADA, YASUKO</au><au>HARADA, SUSUMU</au><au>HARA, KOHEI</au><au>KOGA, HIRONOBU</au><au>RI, YOSHIAKI</au><au>MASUYAMA, TAIJI</au><au>YOSHIMOTO, MASAHIKO</au><au>SHIMOGUCHI, KAZUNORI</au><au>OKUNO, KAZUHIRO</au><au>FUKUSHIMA, KIYOYASU</au><au>NAGATAKE, TSUYOSHI</au><au>HORI, AKIHIRO</au><au>ANDO, MASAYUKI</au><au>SUGA, MORITAKA</au><au>SAITA, NAOKI</au><au>YAMASAKI, TOHRU</au><au>GOTO, JUN</au><au>KITAGAWA, KAZUO</au><au>SAITO, ATSUSHI</au><au>OWAN, ISOKO</au><au>INADOME, JUN</au><au>OGAWA, NOBUYA</au><au>DEGUCHI, KOICHI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A COMPARATIVE STUDY OF TAZOBACTAM/PIPERACILLIN AND PIPERACILLIN IN BACTERIAL PNEUMONIA</atitle><jtitle>Japanese journal of antibiotics</jtitle><addtitle>Jpn. J. Antibiotics</addtitle><date>1995-04</date><risdate>1995</risdate><volume>48</volume><issue>4</issue><spage>449</spage><epage>481</epage><pages>449-481</pages><issn>0368-2781</issn><eissn>2186-5477</eissn><abstract>The efficacy, safety and usefulness of tazobactam/piperacillin (TAZ/PIPC), in bacterial pneumonia and lung abscess were determined with PIPC as the control in a multi-institutional comparative study a penicillin antibiotic for injection prepared by combining a newly developed β-lactamase inhibitor, tazobactam (TAZ), with a broad spectrum penicillin antibiotic, piperacillin (PIPC), at a ratio of 1: 4. TAZ/PIPC was intravenously injected at a dose of 2.5 g (titer) twice a day, and PIPC at a dose of 2.0 g (titer) twice a day as a rule for 14 days. The following results were obtained: 1. The efficacy rates for bacterial pneumonia and lung abscess were 94% (80/85) in TAZ/PIPC group and 89% (70/79) in PIPC group, showing no significant difference between the twogroups. 2. In a comparison of degrees of improvement in clinical symptoms, signs and laboratory findings, there were no significant differences between the two groups except for results on thoracic rales after three days of administration. 3. As for bacteriological effects, the elimination rates of causative organisms were 98% (40/41) in the TAZ/PIPC group and 80% (28/35) in the PIPC group. Thus, the TAZ/PIPC group was significantly superior to the PIPC group. The TAZ/PIPC group showed significantly better eradication of bacateria as well. Bacteria considered to be pyogenic were detected in 80 patients (43 administered TAZ/PIPC and 37 administered PIPC), but β-lactamase production was confirmed in only 11 patients of each group. There were no significant differences in bacteriological effects among these patients. Minimum inhibitory concentrations of TAZ/PIPC against β-lactamase producing organisms were distinctly superior to those of PIPC. 4. Side effects occurred in 10% (10/96) of the TAZ/PIPC group and 7% (7/95) of the PIPC group. Abnormal clinical laboratory test values were observed in 22% (20/92) of the TAZ/PIPC group and 18% (17/93) of the PIPC group. Thus, there were no significant differences between the two administration groups. 5. The usefulness rate in the TAZ/PIPC group was 87% (75/86) and it was 85% (67/79) in the PIPC group, showing no significant difference between them. The results suggest that TAZ/PIPC administered at a dose of 2.5 g (titer) twice a day is more useful than PIPC administered at a dose of 2.0g (titer) twice a day in the treatment of bacterial pneumonia.</abstract><cop>Japan</cop><pub>Japan Antibiotics Research Association</pub><pmid>7783313</pmid><doi>10.11553/antibiotics1968b.48.449</doi><tpages>33</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0368-2781 |
| ispartof | The Japanese Journal of Antibiotics, 1995/04/25, Vol.48(4), pp.449-481 |
| issn | 0368-2781 2186-5477 |
| language | jpn |
| recordid | cdi_proquest_miscellaneous_77333179 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Aged Aged, 80 and over beta-Lactamase Inhibitors Drug Administration Schedule Drug Combinations Female Humans Injections, Intravenous Lung Abscess - drug therapy Lung Abscess - microbiology Male Middle Aged Penicillanic Acid - administration & dosage Penicillanic Acid - analogs & derivatives Piperacillin - administration & dosage Piperacillin - therapeutic use Pneumonia, Bacterial - drug therapy Pneumonia, Bacterial - microbiology |
| title | A COMPARATIVE STUDY OF TAZOBACTAM/PIPERACILLIN AND PIPERACILLIN IN BACTERIAL PNEUMONIA |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T09%3A21%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20COMPARATIVE%20STUDY%20OF%20TAZOBACTAM/PIPERACILLIN%20AND%20PIPERACILLIN%20IN%20BACTERIAL%20PNEUMONIA&rft.jtitle=Japanese%20journal%20of%20antibiotics&rft.au=OIZUMI,%20KOTARO&rft.date=1995-04&rft.volume=48&rft.issue=4&rft.spage=449&rft.epage=481&rft.pages=449-481&rft.issn=0368-2781&rft.eissn=2186-5477&rft_id=info:doi/10.11553/antibiotics1968b.48.449&rft_dat=%3Cproquest_pubme%3E77333179%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=77333179&rft_id=info:pmid/7783313&rfr_iscdi=true |