Steroids and related products. LIII: The synthesis of 11-OXa steroids. V: The synthesis of 17-ethynyl-11-oxatestosterone
The synthesis of 17-ethynyl-11-oxatestosterone, both from 11-oxa-5 alpha-pregnane-3,20-dione and, via a 3,17-dioxygenated 9-oxo 9,12-seco 11-nor 5 alpha-androstane-12-oic ester, from 3 beta-acetoxy-17-hydroxy-5 alpha-pregnan-12-one--two products available from hecogenin--is reported. The new hormone...
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| Veröffentlicht in: | Steroids 1986-06, Vol.47 (6), p.381-399 |
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| container_issue | 6 |
| container_start_page | 381 |
| container_title | Steroids |
| container_volume | 47 |
| creator | ENGEL, C. R MUKHERJEE, D ROY CHOWDHURY, M. N SALVI, V. S |
| description | The synthesis of 17-ethynyl-11-oxatestosterone, both from 11-oxa-5 alpha-pregnane-3,20-dione and, via a 3,17-dioxygenated 9-oxo 9,12-seco 11-nor 5 alpha-androstane-12-oic ester, from 3 beta-acetoxy-17-hydroxy-5 alpha-pregnan-12-one--two products available from hecogenin--is reported. The new hormone analogue shows significant progestational activity in the Clauberg test and relatively weak activity in a post-coital antifertility assay. |
| doi_str_mv | 10.1016/0039-128X(86)90054-1 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0039-128X |
| ispartof | Steroids, 1986-06, Vol.47 (6), p.381-399 |
| issn | 0039-128X 1878-5867 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77332658 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Alicyclic compounds, terpenoids, prostaglandins, steroids Chemistry Exact sciences and technology Organic chemistry Preparations and properties Progesterone Congeners - chemical synthesis Steroids Steroids, Heterocyclic - chemical synthesis Testosterone - analogs & derivatives Testosterone - chemical synthesis |
| title | Steroids and related products. LIII: The synthesis of 11-OXa steroids. V: The synthesis of 17-ethynyl-11-oxatestosterone |
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