Localization of new genes and markers to the distal part of the human major histocompatibility complex (MHC) region and comparison with the mouse: new insights into the evolution of mammalian genomes
We have refined and extended the map of the distal half of the human major histocompatibility complex. The map is continuous from HLA-E to 1000 kb telomeric of HLA-F and includes six new markers and genes. In addition, the corresponding sequences that were not previously mapped in the mouse genome h...
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| Veröffentlicht in: | Genomics 1995-03, Vol.26 (1), p.9-20 |
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| container_title | Genomics |
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| creator | Amadou, C. Ribouchon, M.T. Mattei, M.G. Jenkins, N.A. Gilbert, D.J. Copeland, N.G. Avoustin, P. Pontarotti, P. |
| description | We have refined and extended the map of the distal half of the human major histocompatibility complex. The map is continuous from
HLA-E to 1000 kb telomeric of
HLA-F and includes six new markers and genes. In addition, the corresponding sequences that were not previously mapped in the mouse genome have been located. The human and the mouse organizations have therefore been compared. This comparison allows us to demonstrate that the structure of the distal part of the MHC is similar in the two species. In addition, this comparison shows the presence of a breakpoint of synteny telomeric of the distal part of the
H-2 region. Indeed, the region telomeric of HLA in human is found on a chromosome different from that carrying
H-2 in mouse. The mapping analysis of paralogous genes (structurally related genes) around the breakpoint shows that the human organization probably represents the putative human/mouse ancestral one. This evolutionary breakpoint was precisely mapped in human, and the surrounding region was cloned into yeast artificial chromosomes. Finally, we show that the region found around the breakpoint was involved several times in chromosome recombinations in the mouse lineage, as it seems to correspond also to the
t-complex distal inversion point. |
| doi_str_mv | 10.1016/0888-7543(95)80077-Y |
| format | Article |
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HLA-E to 1000 kb telomeric of
HLA-F and includes six new markers and genes. In addition, the corresponding sequences that were not previously mapped in the mouse genome have been located. The human and the mouse organizations have therefore been compared. This comparison allows us to demonstrate that the structure of the distal part of the MHC is similar in the two species. In addition, this comparison shows the presence of a breakpoint of synteny telomeric of the distal part of the
H-2 region. Indeed, the region telomeric of HLA in human is found on a chromosome different from that carrying
H-2 in mouse. The mapping analysis of paralogous genes (structurally related genes) around the breakpoint shows that the human organization probably represents the putative human/mouse ancestral one. This evolutionary breakpoint was precisely mapped in human, and the surrounding region was cloned into yeast artificial chromosomes. Finally, we show that the region found around the breakpoint was involved several times in chromosome recombinations in the mouse lineage, as it seems to correspond also to the
t-complex distal inversion point.</description><identifier>ISSN: 0888-7543</identifier><identifier>EISSN: 1089-8646</identifier><identifier>DOI: 10.1016/0888-7543(95)80077-Y</identifier><identifier>PMID: 7782091</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Animals ; Base Sequence ; Biological and medical sciences ; BIOLOGICAL EVOLUTION ; BIOLOGY AND MEDICINE, BASIC STUDIES ; Blotting, Southern ; Chromosome Mapping - methods ; Chromosomes, Artificial, Yeast ; Chromosomes, Human, Pair 6 - genetics ; Classical genetics, quantitative genetics, hybrids ; Crosses, Genetic ; DETECTION ; DNA HYBRIDIZATION ; DNA-CLONING ; Electrophoresis, Gel, Pulsed-Field ; Fundamental and applied biological sciences. Psychology ; GENES ; Genes, MHC Class I ; GENETIC MAPPING ; Genetic Markers ; Genetics of eukaryotes. Biological and molecular evolution ; HISTOCOMPATIBILITY COMPLEX ; Human ; Humans ; In Situ Hybridization ; Mice ; Molecular Sequence Data ; POLYMERASE CHAIN REACTION ; Translocation, Genetic</subject><ispartof>Genomics, 1995-03, Vol.26 (1), p.9-20</ispartof><rights>1995</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-90f13a63051189827b7e5f81e30bb188153816f9c8751d5c21244ff8c2b7a20c3</citedby><cites>FETCH-LOGICAL-c412t-90f13a63051189827b7e5f81e30bb188153816f9c8751d5c21244ff8c2b7a20c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0888-7543(95)80077-Y$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,885,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3480885$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7782091$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/249961$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Amadou, C.</creatorcontrib><creatorcontrib>Ribouchon, M.T.</creatorcontrib><creatorcontrib>Mattei, M.G.</creatorcontrib><creatorcontrib>Jenkins, N.A.</creatorcontrib><creatorcontrib>Gilbert, D.J.</creatorcontrib><creatorcontrib>Copeland, N.G.</creatorcontrib><creatorcontrib>Avoustin, P.</creatorcontrib><creatorcontrib>Pontarotti, P.</creatorcontrib><title>Localization of new genes and markers to the distal part of the human major histocompatibility complex (MHC) region and comparison with the mouse: new insights into the evolution of mammalian genomes</title><title>Genomics</title><addtitle>Genomics</addtitle><description>We have refined and extended the map of the distal half of the human major histocompatibility complex. The map is continuous from
HLA-E to 1000 kb telomeric of
HLA-F and includes six new markers and genes. In addition, the corresponding sequences that were not previously mapped in the mouse genome have been located. The human and the mouse organizations have therefore been compared. This comparison allows us to demonstrate that the structure of the distal part of the MHC is similar in the two species. In addition, this comparison shows the presence of a breakpoint of synteny telomeric of the distal part of the
H-2 region. Indeed, the region telomeric of HLA in human is found on a chromosome different from that carrying
H-2 in mouse. The mapping analysis of paralogous genes (structurally related genes) around the breakpoint shows that the human organization probably represents the putative human/mouse ancestral one. This evolutionary breakpoint was precisely mapped in human, and the surrounding region was cloned into yeast artificial chromosomes. Finally, we show that the region found around the breakpoint was involved several times in chromosome recombinations in the mouse lineage, as it seems to correspond also to the
t-complex distal inversion point.</description><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>BIOLOGICAL EVOLUTION</subject><subject>BIOLOGY AND MEDICINE, BASIC STUDIES</subject><subject>Blotting, Southern</subject><subject>Chromosome Mapping - methods</subject><subject>Chromosomes, Artificial, Yeast</subject><subject>Chromosomes, Human, Pair 6 - genetics</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>Crosses, Genetic</subject><subject>DETECTION</subject><subject>DNA HYBRIDIZATION</subject><subject>DNA-CLONING</subject><subject>Electrophoresis, Gel, Pulsed-Field</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GENES</subject><subject>Genes, MHC Class I</subject><subject>GENETIC MAPPING</subject><subject>Genetic Markers</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>HISTOCOMPATIBILITY COMPLEX</subject><subject>Human</subject><subject>Humans</subject><subject>In Situ Hybridization</subject><subject>Mice</subject><subject>Molecular Sequence Data</subject><subject>POLYMERASE CHAIN REACTION</subject><subject>Translocation, Genetic</subject><issn>0888-7543</issn><issn>1089-8646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUhS0EKtPCG4BkJFS1i4CdP9sskNAIKNIgNrDoynKcm4lLYk9tp6W8IK-FMxNmyco_9_O55_og9IKSN5TQ-i3hnGesKosLUV1yQhjLrh-hFSVcZLwu68dodUSeotMQbgghouD5CTphjOdE0BX6s3FaDea3isZZ7Dps4R5vwULAyrZ4VP4n-ICjw7EH3JoQ1YB3yseZna_6aVQ2cTfO4z6VnXbjLqk1ZjDxAc-nAX7hi69X60vsYTu3mZX3mDchHe9N7Pdao5sCvNtbMDaYbR9D2iy94c4N0z-XoxrHZDt1Tl7dCOEZetKpIcDzZT1DPz59_L6-yjbfPn9Zf9hkuqR5zATpaKHqglSUcsFz1jCoOk6hIE1DOadVwWndCc1ZRdtK5zQvy67jOm-YyokuztCrg64L0cigTQTda2ct6CjzUoiaJub8wOy8u50gRDmaoGEYlIU0oWSsKCgVIoHlAdTeheChkztv0pc_SErknLGcA5RzgFJUcp-xvE7PXi76UzNCe3y0hJrqr5e6CincziurTThiRcmTbJWw9wcM0n_dGfDzOGA1tMbP07TO_N_HX-wexfg</recordid><startdate>19950301</startdate><enddate>19950301</enddate><creator>Amadou, C.</creator><creator>Ribouchon, M.T.</creator><creator>Mattei, M.G.</creator><creator>Jenkins, N.A.</creator><creator>Gilbert, D.J.</creator><creator>Copeland, N.G.</creator><creator>Avoustin, P.</creator><creator>Pontarotti, P.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>19950301</creationdate><title>Localization of new genes and markers to the distal part of the human major histocompatibility complex (MHC) region and comparison with the mouse: new insights into the evolution of mammalian genomes</title><author>Amadou, C. ; Ribouchon, M.T. ; Mattei, M.G. ; Jenkins, N.A. ; Gilbert, D.J. ; Copeland, N.G. ; Avoustin, P. ; Pontarotti, P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-90f13a63051189827b7e5f81e30bb188153816f9c8751d5c21244ff8c2b7a20c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>BIOLOGICAL EVOLUTION</topic><topic>BIOLOGY AND MEDICINE, BASIC STUDIES</topic><topic>Blotting, Southern</topic><topic>Chromosome Mapping - methods</topic><topic>Chromosomes, Artificial, Yeast</topic><topic>Chromosomes, Human, Pair 6 - genetics</topic><topic>Classical genetics, quantitative genetics, hybrids</topic><topic>Crosses, Genetic</topic><topic>DETECTION</topic><topic>DNA HYBRIDIZATION</topic><topic>DNA-CLONING</topic><topic>Electrophoresis, Gel, Pulsed-Field</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GENES</topic><topic>Genes, MHC Class I</topic><topic>GENETIC MAPPING</topic><topic>Genetic Markers</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>HISTOCOMPATIBILITY COMPLEX</topic><topic>Human</topic><topic>Humans</topic><topic>In Situ Hybridization</topic><topic>Mice</topic><topic>Molecular Sequence Data</topic><topic>POLYMERASE CHAIN REACTION</topic><topic>Translocation, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Amadou, C.</creatorcontrib><creatorcontrib>Ribouchon, M.T.</creatorcontrib><creatorcontrib>Mattei, M.G.</creatorcontrib><creatorcontrib>Jenkins, N.A.</creatorcontrib><creatorcontrib>Gilbert, D.J.</creatorcontrib><creatorcontrib>Copeland, N.G.</creatorcontrib><creatorcontrib>Avoustin, P.</creatorcontrib><creatorcontrib>Pontarotti, P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Genomics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Amadou, C.</au><au>Ribouchon, M.T.</au><au>Mattei, M.G.</au><au>Jenkins, N.A.</au><au>Gilbert, D.J.</au><au>Copeland, N.G.</au><au>Avoustin, P.</au><au>Pontarotti, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Localization of new genes and markers to the distal part of the human major histocompatibility complex (MHC) region and comparison with the mouse: new insights into the evolution of mammalian genomes</atitle><jtitle>Genomics</jtitle><addtitle>Genomics</addtitle><date>1995-03-01</date><risdate>1995</risdate><volume>26</volume><issue>1</issue><spage>9</spage><epage>20</epage><pages>9-20</pages><issn>0888-7543</issn><eissn>1089-8646</eissn><abstract>We have refined and extended the map of the distal half of the human major histocompatibility complex. The map is continuous from
HLA-E to 1000 kb telomeric of
HLA-F and includes six new markers and genes. In addition, the corresponding sequences that were not previously mapped in the mouse genome have been located. The human and the mouse organizations have therefore been compared. This comparison allows us to demonstrate that the structure of the distal part of the MHC is similar in the two species. In addition, this comparison shows the presence of a breakpoint of synteny telomeric of the distal part of the
H-2 region. Indeed, the region telomeric of HLA in human is found on a chromosome different from that carrying
H-2 in mouse. The mapping analysis of paralogous genes (structurally related genes) around the breakpoint shows that the human organization probably represents the putative human/mouse ancestral one. This evolutionary breakpoint was precisely mapped in human, and the surrounding region was cloned into yeast artificial chromosomes. Finally, we show that the region found around the breakpoint was involved several times in chromosome recombinations in the mouse lineage, as it seems to correspond also to the
t-complex distal inversion point.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>7782091</pmid><doi>10.1016/0888-7543(95)80077-Y</doi><tpages>12</tpages></addata></record> |
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| ispartof | Genomics, 1995-03, Vol.26 (1), p.9-20 |
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| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Animals Base Sequence Biological and medical sciences BIOLOGICAL EVOLUTION BIOLOGY AND MEDICINE, BASIC STUDIES Blotting, Southern Chromosome Mapping - methods Chromosomes, Artificial, Yeast Chromosomes, Human, Pair 6 - genetics Classical genetics, quantitative genetics, hybrids Crosses, Genetic DETECTION DNA HYBRIDIZATION DNA-CLONING Electrophoresis, Gel, Pulsed-Field Fundamental and applied biological sciences. Psychology GENES Genes, MHC Class I GENETIC MAPPING Genetic Markers Genetics of eukaryotes. Biological and molecular evolution HISTOCOMPATIBILITY COMPLEX Human Humans In Situ Hybridization Mice Molecular Sequence Data POLYMERASE CHAIN REACTION Translocation, Genetic |
| title | Localization of new genes and markers to the distal part of the human major histocompatibility complex (MHC) region and comparison with the mouse: new insights into the evolution of mammalian genomes |
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