Antibiotic Prophylaxis in High-Risk Head and Neck Surgery: One-Day vs. Five-Day Therapy
Patients who undergo major contaminated surgery of the head and neck benefit from perioperative antibiotic prophylaxis. This study was developed to determine if 5 days of antibiotic administration would be more effective than 1 day. A multi-institutional prospective randomized double-blind study was...
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| Veröffentlicht in: | Otolaryngology-head and neck surgery 1986-12, Vol.95 (5), p.554-557 |
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| container_title | Otolaryngology-head and neck surgery |
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| creator | Johnson, Jonas T. Schuller, David E. Silver, Fred Gluckman, Jack L. Newman, Richard K. Shagets, Frank W. Snyderman, Nancy L. Leipzig, Bruce Wagner, Robin L. |
| description | Patients who undergo major contaminated surgery of the head and neck benefit from perioperative antibiotic prophylaxis. This study was developed to determine if 5 days of antibiotic administration would be more effective than 1 day. A multi-institutional prospective randomized double-blind study was designed. Patients who were identified as requiring pedicled flap reconstruction were potential candidates for the study. Later, patients were randomly assigned to receive cefoperazone sodium for either 24 hours or 120 hours. In each case, the drug was administered intravenously, beginning 1 to 2 hours preoperatively and continued for the prescribed period. One hundred nine patients were evaluable. Fifty-three patients were assigned to 1 day of perioperative prophylaxis. Wound Infection developed in ten patients (18.9%). Fifty-six patients were assigned to 5 days of perioperative antibiotic prophylaxis. Wound infection developed in 14 (25%) of these patients (P >.05). These data suggest that no beneficial effect from administration of antibiotics for longer than 24 hours postoperatively can be achieved in patients who undergo myocutaneous flap reconstruction. |
| doi_str_mv | 10.1177/019459988609500506 |
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This study was developed to determine if 5 days of antibiotic administration would be more effective than 1 day. A multi-institutional prospective randomized double-blind study was designed. Patients who were identified as requiring pedicled flap reconstruction were potential candidates for the study. Later, patients were randomly assigned to receive cefoperazone sodium for either 24 hours or 120 hours. In each case, the drug was administered intravenously, beginning 1 to 2 hours preoperatively and continued for the prescribed period. One hundred nine patients were evaluable. Fifty-three patients were assigned to 1 day of perioperative prophylaxis. Wound Infection developed in ten patients (18.9%). Fifty-six patients were assigned to 5 days of perioperative antibiotic prophylaxis. Wound infection developed in 14 (25%) of these patients (P >.05). These data suggest that no beneficial effect from administration of antibiotics for longer than 24 hours postoperatively can be achieved in patients who undergo myocutaneous flap reconstruction.</description><identifier>ISSN: 0194-5998</identifier><identifier>EISSN: 1097-6817</identifier><identifier>DOI: 10.1177/019459988609500506</identifier><identifier>PMID: 3108794</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Cefoperazone - administration & dosage ; Cefoperazone - therapeutic use ; Clinical Trials as Topic ; Double-Blind Method ; Drug Administration Schedule ; Humans ; Otorhinolaryngologic Diseases - surgery ; Premedication ; Prospective Studies ; Random Allocation ; Surgical Flaps ; Surgical Wound Infection - prevention & control ; Time Factors</subject><ispartof>Otolaryngology-head and neck surgery, 1986-12, Vol.95 (5), p.554-557</ispartof><rights>1986 SAGE Publications</rights><rights>1986 American Association of Otolaryngology‐Head and Neck Surgery Foundation (AAO‐HNSF)</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3049-9748ad170e70aa10a05433bac35e870dfc0222ef9d99d0a182ab6020553c89253</citedby><cites>FETCH-LOGICAL-c3049-9748ad170e70aa10a05433bac35e870dfc0222ef9d99d0a182ab6020553c89253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1177%2F019459988609500506$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1177%2F019459988609500506$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3108794$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Johnson, Jonas T.</creatorcontrib><creatorcontrib>Schuller, David E.</creatorcontrib><creatorcontrib>Silver, Fred</creatorcontrib><creatorcontrib>Gluckman, Jack L.</creatorcontrib><creatorcontrib>Newman, Richard K.</creatorcontrib><creatorcontrib>Shagets, Frank W.</creatorcontrib><creatorcontrib>Snyderman, Nancy L.</creatorcontrib><creatorcontrib>Leipzig, Bruce</creatorcontrib><creatorcontrib>Wagner, Robin L.</creatorcontrib><title>Antibiotic Prophylaxis in High-Risk Head and Neck Surgery: One-Day vs. Five-Day Therapy</title><title>Otolaryngology-head and neck surgery</title><addtitle>Otolaryngol Head Neck Surg</addtitle><description>Patients who undergo major contaminated surgery of the head and neck benefit from perioperative antibiotic prophylaxis. This study was developed to determine if 5 days of antibiotic administration would be more effective than 1 day. A multi-institutional prospective randomized double-blind study was designed. Patients who were identified as requiring pedicled flap reconstruction were potential candidates for the study. Later, patients were randomly assigned to receive cefoperazone sodium for either 24 hours or 120 hours. In each case, the drug was administered intravenously, beginning 1 to 2 hours preoperatively and continued for the prescribed period. One hundred nine patients were evaluable. Fifty-three patients were assigned to 1 day of perioperative prophylaxis. Wound Infection developed in ten patients (18.9%). Fifty-six patients were assigned to 5 days of perioperative antibiotic prophylaxis. Wound infection developed in 14 (25%) of these patients (P >.05). These data suggest that no beneficial effect from administration of antibiotics for longer than 24 hours postoperatively can be achieved in patients who undergo myocutaneous flap reconstruction.</description><subject>Cefoperazone - administration & dosage</subject><subject>Cefoperazone - therapeutic use</subject><subject>Clinical Trials as Topic</subject><subject>Double-Blind Method</subject><subject>Drug Administration Schedule</subject><subject>Humans</subject><subject>Otorhinolaryngologic Diseases - surgery</subject><subject>Premedication</subject><subject>Prospective Studies</subject><subject>Random Allocation</subject><subject>Surgical Flaps</subject><subject>Surgical Wound Infection - prevention & control</subject><subject>Time Factors</subject><issn>0194-5998</issn><issn>1097-6817</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEFPwkAQhTdGg4j-AROTPXkrzLbdbpcbolgTAkYxHpttu4WF0tZdivbfW1LixcR4mszMey8zH0LXBPqEMDYAwl3Kue97wCkABe8EdQlwZnk-YaeoexBYB8U5ujBmDQCex1gHdRwCPuNuF72P8p2KVLFTMX7WRbmqM_GlDFY5DtRyZb0os8GBFAkWeYJnMt7g10ovpa6HeJ5L617UeG_6eKL2bbNYSS3K-hKdpSIz8upYe-ht8rAYB9Z0_vg0Hk2t2AGXW5y5vkgIA8lACAICqOs4kYgdKn0GSRqDbdsy5QnnCQji2yLywAZKndjnNnV66LbNLXXxUUmzC7fKxDLLRC6LyoSMOc2v1GuEdiuMdWGMlmlYarUVug4JhAea4W-ajenmmF5FW5n8WI74mv2w3X-qTNb_SAznwexu0sxt3pgHrdmIpQzXRaXzhtRf53wDfN-K5Q</recordid><startdate>198612</startdate><enddate>198612</enddate><creator>Johnson, Jonas T.</creator><creator>Schuller, David E.</creator><creator>Silver, Fred</creator><creator>Gluckman, Jack L.</creator><creator>Newman, Richard K.</creator><creator>Shagets, Frank W.</creator><creator>Snyderman, Nancy L.</creator><creator>Leipzig, Bruce</creator><creator>Wagner, Robin L.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>198612</creationdate><title>Antibiotic Prophylaxis in High-Risk Head and Neck Surgery: One-Day vs. Five-Day Therapy</title><author>Johnson, Jonas T. ; Schuller, David E. ; Silver, Fred ; Gluckman, Jack L. ; Newman, Richard K. ; Shagets, Frank W. ; Snyderman, Nancy L. ; Leipzig, Bruce ; Wagner, Robin L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3049-9748ad170e70aa10a05433bac35e870dfc0222ef9d99d0a182ab6020553c89253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Cefoperazone - administration & dosage</topic><topic>Cefoperazone - therapeutic use</topic><topic>Clinical Trials as Topic</topic><topic>Double-Blind Method</topic><topic>Drug Administration Schedule</topic><topic>Humans</topic><topic>Otorhinolaryngologic Diseases - surgery</topic><topic>Premedication</topic><topic>Prospective Studies</topic><topic>Random Allocation</topic><topic>Surgical Flaps</topic><topic>Surgical Wound Infection - prevention & control</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Johnson, Jonas T.</creatorcontrib><creatorcontrib>Schuller, David E.</creatorcontrib><creatorcontrib>Silver, Fred</creatorcontrib><creatorcontrib>Gluckman, Jack L.</creatorcontrib><creatorcontrib>Newman, Richard K.</creatorcontrib><creatorcontrib>Shagets, Frank W.</creatorcontrib><creatorcontrib>Snyderman, Nancy L.</creatorcontrib><creatorcontrib>Leipzig, Bruce</creatorcontrib><creatorcontrib>Wagner, Robin L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Otolaryngology-head and neck surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Johnson, Jonas T.</au><au>Schuller, David E.</au><au>Silver, Fred</au><au>Gluckman, Jack L.</au><au>Newman, Richard K.</au><au>Shagets, Frank W.</au><au>Snyderman, Nancy L.</au><au>Leipzig, Bruce</au><au>Wagner, Robin L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antibiotic Prophylaxis in High-Risk Head and Neck Surgery: One-Day vs. Five-Day Therapy</atitle><jtitle>Otolaryngology-head and neck surgery</jtitle><addtitle>Otolaryngol Head Neck Surg</addtitle><date>1986-12</date><risdate>1986</risdate><volume>95</volume><issue>5</issue><spage>554</spage><epage>557</epage><pages>554-557</pages><issn>0194-5998</issn><eissn>1097-6817</eissn><abstract>Patients who undergo major contaminated surgery of the head and neck benefit from perioperative antibiotic prophylaxis. This study was developed to determine if 5 days of antibiotic administration would be more effective than 1 day. A multi-institutional prospective randomized double-blind study was designed. Patients who were identified as requiring pedicled flap reconstruction were potential candidates for the study. Later, patients were randomly assigned to receive cefoperazone sodium for either 24 hours or 120 hours. In each case, the drug was administered intravenously, beginning 1 to 2 hours preoperatively and continued for the prescribed period. One hundred nine patients were evaluable. Fifty-three patients were assigned to 1 day of perioperative prophylaxis. Wound Infection developed in ten patients (18.9%). Fifty-six patients were assigned to 5 days of perioperative antibiotic prophylaxis. Wound infection developed in 14 (25%) of these patients (P >.05). These data suggest that no beneficial effect from administration of antibiotics for longer than 24 hours postoperatively can be achieved in patients who undergo myocutaneous flap reconstruction.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>3108794</pmid><doi>10.1177/019459988609500506</doi><tpages>4</tpages></addata></record> |
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| ispartof | Otolaryngology-head and neck surgery, 1986-12, Vol.95 (5), p.554-557 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Cefoperazone - administration & dosage Cefoperazone - therapeutic use Clinical Trials as Topic Double-Blind Method Drug Administration Schedule Humans Otorhinolaryngologic Diseases - surgery Premedication Prospective Studies Random Allocation Surgical Flaps Surgical Wound Infection - prevention & control Time Factors |
| title | Antibiotic Prophylaxis in High-Risk Head and Neck Surgery: One-Day vs. Five-Day Therapy |
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