Effects of chronic activation of dopamine D-2 receptors in cultures of rat fetal dopaminergic neurons: indications for alterations in functional activity

In Parkinsonian patients, previously subjected to neuronal grafting therapy, the survival and functional status of dopaminergic grafts might be impaired by the concurrent pharmacotherapy with l-DOPA and/or dopamine (DA) D-2 receptor agonists. To test this hypothesis in vitro, we studied the effects...

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Veröffentlicht in:	Brain research. Developmental brain research 1995-03, Vol.85 (1), p.128-136
Hauptverfasser:	Van Muiswinkel, Freek L., Jongenelen, Cornells A.M., Schepens, Hendrikus T.W.J., Stoof, Johannes C., Drukarch, Benjamin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured - physiology Chromatography, High Pressure Liquid Dopamine - analysis Dopamine - biosynthesis Dopamine D-2 receptor Dopamine synthesis High-performance liquid chromatography Mesencephalon Mesencephalon - cytology Neurons - physiology Parkinson's disease Potassium Channels - physiology Rats Receptors, Dopamine D2 - agonists Time Factors Tritium Tyrosine 3-Monooxygenase - analysis Tyrosine hydroxylase
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