Hyperosmolar non-ketotic diabetic coma as a cause of emergency hyperglycaemic admission to Baragwanath hospital
There were 136 emergency hyperglycaemic admissions to Baragwanath Hospital over a 6-month period during 1992-1993, representing 1.2% of the total number of medical admissions; 24 (18%) patients died. Diabetic keto-acidosis (DKA) accounted for 88 (65%) admissions (mortality rate 9%) while 16 admissio...
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| Veröffentlicht in: | South African medical journal 1995-03, Vol.85 (3), p.173-176 |
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| container_title | South African medical journal |
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| creator | ROLFE, M EPHRAIM, G. G LINCOLN, D. C HUDDLE, K. R. L |
| description | There were 136 emergency hyperglycaemic admissions to Baragwanath Hospital over a 6-month period during 1992-1993, representing 1.2% of the total number of medical admissions; 24 (18%) patients died. Diabetic keto-acidosis (DKA) accounted for 88 (65%) admissions (mortality rate 9%) while 16 admissions (12%) were as a result of hyperosmolar non-ketotic coma (HNKC), defined as hyperglycaemia, dehydration and an altered level of consciousness with a plasma osmolality > or = 330 and an arterial pH > or = 7.30, with absent or minimal ketonuria. Of these 16 patients, 9 (56%) were known to have diabetes mellitus. Patients with HNKC were significantly older than those with DKA (P < 0.001) and other patients with nonketotic hyperglycaemia (P < 0.05). The overall mortality rate was 44%; prophylactic low-molecular-weight heparin appeared of benefit (P < 0.05). |
| format | Article |
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The overall mortality rate was 44%; prophylactic low-molecular-weight heparin appeared of benefit (P < 0.05).</description><identifier>ISSN: 0256-9574</identifier><identifier>PMID: 7777971</identifier><identifier>CODEN: SAMJAF</identifier><language>eng</language><publisher>Pinelands: Medical Association of South Africa</publisher><subject>Adult ; Age Factors ; Aged ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Blood Glucose - analysis ; Diabetes Complications ; Diabetic Ketoacidosis - blood ; Diabetic Ketoacidosis - diagnosis ; Diabetic Ketoacidosis - mortality ; Emergencies ; Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition ; Female ; Hospitalization ; Humans ; Hyperglycemic Hyperosmolar Nonketotic Coma - blood ; Hyperglycemic Hyperosmolar Nonketotic Coma - diagnosis ; Hyperglycemic Hyperosmolar Nonketotic Coma - mortality ; Intensive care medicine ; Male ; Medical sciences ; Potassium - blood ; Sodium - blood ; Tropical medicine ; Urea - blood</subject><ispartof>South African medical journal, 1995-03, Vol.85 (3), p.173-176</ispartof><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3484124$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7777971$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ROLFE, M</creatorcontrib><creatorcontrib>EPHRAIM, G. G</creatorcontrib><creatorcontrib>LINCOLN, D. C</creatorcontrib><creatorcontrib>HUDDLE, K. R. L</creatorcontrib><title>Hyperosmolar non-ketotic diabetic coma as a cause of emergency hyperglycaemic admission to Baragwanath hospital</title><title>South African medical journal</title><addtitle>S Afr Med J</addtitle><description>There were 136 emergency hyperglycaemic admissions to Baragwanath Hospital over a 6-month period during 1992-1993, representing 1.2% of the total number of medical admissions; 24 (18%) patients died. Diabetic keto-acidosis (DKA) accounted for 88 (65%) admissions (mortality rate 9%) while 16 admissions (12%) were as a result of hyperosmolar non-ketotic coma (HNKC), defined as hyperglycaemia, dehydration and an altered level of consciousness with a plasma osmolality > or = 330 and an arterial pH > or = 7.30, with absent or minimal ketonuria. Of these 16 patients, 9 (56%) were known to have diabetes mellitus. Patients with HNKC were significantly older than those with DKA (P < 0.001) and other patients with nonketotic hyperglycaemia (P < 0.05). The overall mortality rate was 44%; prophylactic low-molecular-weight heparin appeared of benefit (P < 0.05).</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - analysis</subject><subject>Diabetes Complications</subject><subject>Diabetic Ketoacidosis - blood</subject><subject>Diabetic Ketoacidosis - diagnosis</subject><subject>Diabetic Ketoacidosis - mortality</subject><subject>Emergencies</subject><subject>Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition</subject><subject>Female</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Hyperglycemic Hyperosmolar Nonketotic Coma - blood</subject><subject>Hyperglycemic Hyperosmolar Nonketotic Coma - diagnosis</subject><subject>Hyperglycemic Hyperosmolar Nonketotic Coma - mortality</subject><subject>Intensive care medicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Potassium - blood</subject><subject>Sodium - blood</subject><subject>Tropical medicine</subject><subject>Urea - blood</subject><issn>0256-9574</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEFLxDAQhXtQ1nX1Jwg5iLdC2jRNetRFXWHBi57LJJnuRtumJinSf2-XLc7lzfC-eQxzkaxpzsu04qK4Sq5D-KLzzKtylazEXJXI1onbTQN6FzrXgie969NvjC5aTYwFhadGuw4IBAJEwxiQuIZgh_6AvZ7I8bR-aCcN2M0smM6GYF1PoiNP4OHwCz3EIzm6MNgI7U1y2UAb8HbRTfL58vyx3aX799e37eM-HTJOYwpSS8oYoOJVoygVMpN5LhhVIEsBMpcStTKlLgyX2jSmUpBljBeqAjRGsk3ycM4dvPsZMcR6Pkxj20KPbgy1ECwvKeUzeLeAo-rQ1IO3HfipXj40-_eLD0FD23jotQ3_GCtkkeUF-wNtbHB6</recordid><startdate>199503</startdate><enddate>199503</enddate><creator>ROLFE, M</creator><creator>EPHRAIM, G. 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Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - analysis</topic><topic>Diabetes Complications</topic><topic>Diabetic Ketoacidosis - blood</topic><topic>Diabetic Ketoacidosis - diagnosis</topic><topic>Diabetic Ketoacidosis - mortality</topic><topic>Emergencies</topic><topic>Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition</topic><topic>Female</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Hyperglycemic Hyperosmolar Nonketotic Coma - blood</topic><topic>Hyperglycemic Hyperosmolar Nonketotic Coma - diagnosis</topic><topic>Hyperglycemic Hyperosmolar Nonketotic Coma - mortality</topic><topic>Intensive care medicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Potassium - blood</topic><topic>Sodium - blood</topic><topic>Tropical medicine</topic><topic>Urea - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ROLFE, M</creatorcontrib><creatorcontrib>EPHRAIM, G. G</creatorcontrib><creatorcontrib>LINCOLN, D. C</creatorcontrib><creatorcontrib>HUDDLE, K. R. 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L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hyperosmolar non-ketotic diabetic coma as a cause of emergency hyperglycaemic admission to Baragwanath hospital</atitle><jtitle>South African medical journal</jtitle><addtitle>S Afr Med J</addtitle><date>1995-03</date><risdate>1995</risdate><volume>85</volume><issue>3</issue><spage>173</spage><epage>176</epage><pages>173-176</pages><issn>0256-9574</issn><coden>SAMJAF</coden><abstract>There were 136 emergency hyperglycaemic admissions to Baragwanath Hospital over a 6-month period during 1992-1993, representing 1.2% of the total number of medical admissions; 24 (18%) patients died. Diabetic keto-acidosis (DKA) accounted for 88 (65%) admissions (mortality rate 9%) while 16 admissions (12%) were as a result of hyperosmolar non-ketotic coma (HNKC), defined as hyperglycaemia, dehydration and an altered level of consciousness with a plasma osmolality > or = 330 and an arterial pH > or = 7.30, with absent or minimal ketonuria. Of these 16 patients, 9 (56%) were known to have diabetes mellitus. Patients with HNKC were significantly older than those with DKA (P < 0.001) and other patients with nonketotic hyperglycaemia (P < 0.05). The overall mortality rate was 44%; prophylactic low-molecular-weight heparin appeared of benefit (P < 0.05).</abstract><cop>Pinelands</cop><pub>Medical Association of South Africa</pub><pmid>7777971</pmid><tpages>4</tpages></addata></record> |
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| ispartof | South African medical journal, 1995-03, Vol.85 (3), p.173-176 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Age Factors Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Blood Glucose - analysis Diabetes Complications Diabetic Ketoacidosis - blood Diabetic Ketoacidosis - diagnosis Diabetic Ketoacidosis - mortality Emergencies Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition Female Hospitalization Humans Hyperglycemic Hyperosmolar Nonketotic Coma - blood Hyperglycemic Hyperosmolar Nonketotic Coma - diagnosis Hyperglycemic Hyperosmolar Nonketotic Coma - mortality Intensive care medicine Male Medical sciences Potassium - blood Sodium - blood Tropical medicine Urea - blood |
| title | Hyperosmolar non-ketotic diabetic coma as a cause of emergency hyperglycaemic admission to Baragwanath hospital |
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