Nicotinic Acid Decreases Serum Thyroid Hormone Levels While Maintaining a Euthyroid State
To evaluate the effects of nicotinic acid on serum thyroid hormone levels in the absence of systemic illness or hepatic dysfunction. We determined the effect of treatment with nicotinic acid on serum thyroid hormone levels in one female and four male patients (mean age, 44.4 years) with hyperlipidem...
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| Veröffentlicht in: | Mayo Clinic proceedings 1995-06, Vol.70 (6), p.556-558 |
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| creator | Mohamed Shakir, K.M. Kroll, Sherry Aprill, Brian S. Drake, Almond J. Eisold, John F. |
| description | To evaluate the effects of nicotinic acid on serum thyroid hormone levels in the absence of systemic illness or hepatic dysfunction.
We determined the effect of treatment with nicotinic acid on serum thyroid hormone levels in one female and four male patients (mean age, 44.4 years) with hyperlipidemia.
In the five study patients, we measured serum lipids in conjunction with serum thyroxine (T4), triiodothyronine (T3) resin uptake, T3, free T4, thyroid-stimulating hormone (TSH), and thyroxine-binding globulin before, during, and after treatment with nicotinic acid.
Serum lipid levels responded appropriately to nicotinic acid treatment. Thyroid function studies done a mean of 1.3 years (range, 0.5 to 3.5) after initiation of nicotinic acid therapy (mean daily dose, 2.6 ± 0.7 g) revealed significant decreases in serum levels of total T4 (21 %), free T4 index (16%), T3 (13 %), and thyroxine-binding globulin (23 %) (P |
| doi_str_mv | 10.4065/70.6.556 |
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We determined the effect of treatment with nicotinic acid on serum thyroid hormone levels in one female and four male patients (mean age, 44.4 years) with hyperlipidemia.
In the five study patients, we measured serum lipids in conjunction with serum thyroxine (T4), triiodothyronine (T3) resin uptake, T3, free T4, thyroid-stimulating hormone (TSH), and thyroxine-binding globulin before, during, and after treatment with nicotinic acid.
Serum lipid levels responded appropriately to nicotinic acid treatment. Thyroid function studies done a mean of 1.3 years (range, 0.5 to 3.5) after initiation of nicotinic acid therapy (mean daily dose, 2.6 ± 0.7 g) revealed significant decreases in serum levels of total T4 (21 %), free T4 index (16%), T3 (13 %), and thyroxine-binding globulin (23 %) (P<0.02) whereas no significant changes were noted in free T4, T3 resin uptake, and TSH levels. During the course of treatment, the patients, who were carefully questioned, had no symptoms of hypothyroidism. Hypothyroidism was further excluded in three patients who had a normal serum TSH response to administration of thyrotropin-releasing hormone. In two patients, measurements of thyroid function returned to pretreatment levels after discontinuation of nicotinic acid therapy. No patient had significant abnormalities in liver-associated enzymes or evidence of systemic illness during the course of treatment.
These results suggest that nicotinic acid decreases serum thyroid hormone concentrations while maintaining a euthyroid state. This effect may be mediated through reduction in thyroxine-binding globulin, but other mechanisms may also be involved.</description><identifier>ISSN: 0025-6196</identifier><identifier>EISSN: 1942-5546</identifier><identifier>DOI: 10.4065/70.6.556</identifier><identifier>PMID: 7776715</identifier><identifier>CODEN: MACPAJ</identifier><language>eng</language><publisher>Rochester, MN: Elsevier Inc</publisher><subject>Adult ; Analgesics ; Biological and medical sciences ; Female ; Humans ; Hyperlipidemias - blood ; Hyperlipidemias - drug therapy ; Liver - drug effects ; Liver - physiology ; Liver Function Tests ; Male ; Medical sciences ; Middle Aged ; Neuropharmacology ; Niacin - pharmacology ; Niacin - therapeutic use ; Pharmacology. Drug treatments ; Thyroid Function Tests ; Thyroid Gland - drug effects ; Thyroid Gland - physiology ; Thyrotropin - blood ; Thyrotropin - drug effects ; Thyroxine - blood ; Thyroxine - drug effects ; Thyroxine-Binding Proteins - drug effects ; Triiodothyronine - blood ; Triiodothyronine - drug effects</subject><ispartof>Mayo Clinic proceedings, 1995-06, Vol.70 (6), p.556-558</ispartof><rights>1995 Mayo Foundation for Medical Education and Research</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c350t-d4adba86843d753bebbf0e4e011c16d2189e980266985999ac4d10cf518da6b63</citedby><cites>FETCH-LOGICAL-c350t-d4adba86843d753bebbf0e4e011c16d2189e980266985999ac4d10cf518da6b63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3565740$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7776715$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mohamed Shakir, K.M.</creatorcontrib><creatorcontrib>Kroll, Sherry</creatorcontrib><creatorcontrib>Aprill, Brian S.</creatorcontrib><creatorcontrib>Drake, Almond J.</creatorcontrib><creatorcontrib>Eisold, John F.</creatorcontrib><title>Nicotinic Acid Decreases Serum Thyroid Hormone Levels While Maintaining a Euthyroid State</title><title>Mayo Clinic proceedings</title><addtitle>Mayo Clin Proc</addtitle><description>To evaluate the effects of nicotinic acid on serum thyroid hormone levels in the absence of systemic illness or hepatic dysfunction.
We determined the effect of treatment with nicotinic acid on serum thyroid hormone levels in one female and four male patients (mean age, 44.4 years) with hyperlipidemia.
In the five study patients, we measured serum lipids in conjunction with serum thyroxine (T4), triiodothyronine (T3) resin uptake, T3, free T4, thyroid-stimulating hormone (TSH), and thyroxine-binding globulin before, during, and after treatment with nicotinic acid.
Serum lipid levels responded appropriately to nicotinic acid treatment. Thyroid function studies done a mean of 1.3 years (range, 0.5 to 3.5) after initiation of nicotinic acid therapy (mean daily dose, 2.6 ± 0.7 g) revealed significant decreases in serum levels of total T4 (21 %), free T4 index (16%), T3 (13 %), and thyroxine-binding globulin (23 %) (P<0.02) whereas no significant changes were noted in free T4, T3 resin uptake, and TSH levels. During the course of treatment, the patients, who were carefully questioned, had no symptoms of hypothyroidism. Hypothyroidism was further excluded in three patients who had a normal serum TSH response to administration of thyrotropin-releasing hormone. In two patients, measurements of thyroid function returned to pretreatment levels after discontinuation of nicotinic acid therapy. No patient had significant abnormalities in liver-associated enzymes or evidence of systemic illness during the course of treatment.
These results suggest that nicotinic acid decreases serum thyroid hormone concentrations while maintaining a euthyroid state. This effect may be mediated through reduction in thyroxine-binding globulin, but other mechanisms may also be involved.</description><subject>Adult</subject><subject>Analgesics</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Humans</subject><subject>Hyperlipidemias - blood</subject><subject>Hyperlipidemias - drug therapy</subject><subject>Liver - drug effects</subject><subject>Liver - physiology</subject><subject>Liver Function Tests</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neuropharmacology</subject><subject>Niacin - pharmacology</subject><subject>Niacin - therapeutic use</subject><subject>Pharmacology. Drug treatments</subject><subject>Thyroid Function Tests</subject><subject>Thyroid Gland - drug effects</subject><subject>Thyroid Gland - physiology</subject><subject>Thyrotropin - blood</subject><subject>Thyrotropin - drug effects</subject><subject>Thyroxine - blood</subject><subject>Thyroxine - drug effects</subject><subject>Thyroxine-Binding Proteins - drug effects</subject><subject>Triiodothyronine - blood</subject><subject>Triiodothyronine - drug effects</subject><issn>0025-6196</issn><issn>1942-5546</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkMtKxDAUhoMo43gBX0DIQsRNx6TNpVnKOF5g1MUo4iqkyalGetGkHfDtrUyZjYvDgfN__Ac-hE4omTEi-KUkMzHjXOygKVUsTThnYhdNCUl5IqgS--ggxk9CiFSKTdBESikk5VP09uht2_nGW3xlvcPXYAOYCBGvIPQ1fv74Ce1wv2tD3TaAl7CGKuLXD18BfjC-6YbxzTs2eNF3I7zqTAdHaK80VYTjcR-il5vF8_wuWT7d3s-vlonNOOkSx4wrTC5yljnJswKKoiTAgFBqqXApzRWonKRCqJwrpYxljhJbcpo7IwqRHaLzTe9XaL97iJ2ufbRQVaaBto9ayixlitEBvNiANrQxBij1V_C1CT-aEv1nUUuihR4sDujp2NkXNbgtOGob8rMxN9GaqgymsT5usYwLLhkZsHSDDcpg7SHoaD00FpwPYDvtWv__9y839Ymd</recordid><startdate>19950601</startdate><enddate>19950601</enddate><creator>Mohamed Shakir, K.M.</creator><creator>Kroll, Sherry</creator><creator>Aprill, Brian S.</creator><creator>Drake, Almond J.</creator><creator>Eisold, John F.</creator><general>Elsevier Inc</general><general>Mayo Medical Ventures</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19950601</creationdate><title>Nicotinic Acid Decreases Serum Thyroid Hormone Levels While Maintaining a Euthyroid State</title><author>Mohamed Shakir, K.M. ; Kroll, Sherry ; Aprill, Brian S. ; Drake, Almond J. ; Eisold, John F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c350t-d4adba86843d753bebbf0e4e011c16d2189e980266985999ac4d10cf518da6b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adult</topic><topic>Analgesics</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Humans</topic><topic>Hyperlipidemias - blood</topic><topic>Hyperlipidemias - drug therapy</topic><topic>Liver - drug effects</topic><topic>Liver - physiology</topic><topic>Liver Function Tests</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neuropharmacology</topic><topic>Niacin - pharmacology</topic><topic>Niacin - therapeutic use</topic><topic>Pharmacology. Drug treatments</topic><topic>Thyroid Function Tests</topic><topic>Thyroid Gland - drug effects</topic><topic>Thyroid Gland - physiology</topic><topic>Thyrotropin - blood</topic><topic>Thyrotropin - drug effects</topic><topic>Thyroxine - blood</topic><topic>Thyroxine - drug effects</topic><topic>Thyroxine-Binding Proteins - drug effects</topic><topic>Triiodothyronine - blood</topic><topic>Triiodothyronine - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mohamed Shakir, K.M.</creatorcontrib><creatorcontrib>Kroll, Sherry</creatorcontrib><creatorcontrib>Aprill, Brian S.</creatorcontrib><creatorcontrib>Drake, Almond J.</creatorcontrib><creatorcontrib>Eisold, John F.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Mayo Clinic proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mohamed Shakir, K.M.</au><au>Kroll, Sherry</au><au>Aprill, Brian S.</au><au>Drake, Almond J.</au><au>Eisold, John F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nicotinic Acid Decreases Serum Thyroid Hormone Levels While Maintaining a Euthyroid State</atitle><jtitle>Mayo Clinic proceedings</jtitle><addtitle>Mayo Clin Proc</addtitle><date>1995-06-01</date><risdate>1995</risdate><volume>70</volume><issue>6</issue><spage>556</spage><epage>558</epage><pages>556-558</pages><issn>0025-6196</issn><eissn>1942-5546</eissn><coden>MACPAJ</coden><abstract>To evaluate the effects of nicotinic acid on serum thyroid hormone levels in the absence of systemic illness or hepatic dysfunction.
We determined the effect of treatment with nicotinic acid on serum thyroid hormone levels in one female and four male patients (mean age, 44.4 years) with hyperlipidemia.
In the five study patients, we measured serum lipids in conjunction with serum thyroxine (T4), triiodothyronine (T3) resin uptake, T3, free T4, thyroid-stimulating hormone (TSH), and thyroxine-binding globulin before, during, and after treatment with nicotinic acid.
Serum lipid levels responded appropriately to nicotinic acid treatment. Thyroid function studies done a mean of 1.3 years (range, 0.5 to 3.5) after initiation of nicotinic acid therapy (mean daily dose, 2.6 ± 0.7 g) revealed significant decreases in serum levels of total T4 (21 %), free T4 index (16%), T3 (13 %), and thyroxine-binding globulin (23 %) (P<0.02) whereas no significant changes were noted in free T4, T3 resin uptake, and TSH levels. During the course of treatment, the patients, who were carefully questioned, had no symptoms of hypothyroidism. Hypothyroidism was further excluded in three patients who had a normal serum TSH response to administration of thyrotropin-releasing hormone. In two patients, measurements of thyroid function returned to pretreatment levels after discontinuation of nicotinic acid therapy. No patient had significant abnormalities in liver-associated enzymes or evidence of systemic illness during the course of treatment.
These results suggest that nicotinic acid decreases serum thyroid hormone concentrations while maintaining a euthyroid state. This effect may be mediated through reduction in thyroxine-binding globulin, but other mechanisms may also be involved.</abstract><cop>Rochester, MN</cop><pub>Elsevier Inc</pub><pmid>7776715</pmid><doi>10.4065/70.6.556</doi><tpages>3</tpages></addata></record> |
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| ispartof | Mayo Clinic proceedings, 1995-06, Vol.70 (6), p.556-558 |
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| subjects | Adult Analgesics Biological and medical sciences Female Humans Hyperlipidemias - blood Hyperlipidemias - drug therapy Liver - drug effects Liver - physiology Liver Function Tests Male Medical sciences Middle Aged Neuropharmacology Niacin - pharmacology Niacin - therapeutic use Pharmacology. Drug treatments Thyroid Function Tests Thyroid Gland - drug effects Thyroid Gland - physiology Thyrotropin - blood Thyrotropin - drug effects Thyroxine - blood Thyroxine - drug effects Thyroxine-Binding Proteins - drug effects Triiodothyronine - blood Triiodothyronine - drug effects |
| title | Nicotinic Acid Decreases Serum Thyroid Hormone Levels While Maintaining a Euthyroid State |
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