Nicotinic Acid Decreases Serum Thyroid Hormone Levels While Maintaining a Euthyroid State
To evaluate the effects of nicotinic acid on serum thyroid hormone levels in the absence of systemic illness or hepatic dysfunction. We determined the effect of treatment with nicotinic acid on serum thyroid hormone levels in one female and four male patients (mean age, 44.4 years) with hyperlipidem...
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Veröffentlicht in: | Mayo Clinic proceedings 1995-06, Vol.70 (6), p.556-558 |
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Zusammenfassung: | To evaluate the effects of nicotinic acid on serum thyroid hormone levels in the absence of systemic illness or hepatic dysfunction.
We determined the effect of treatment with nicotinic acid on serum thyroid hormone levels in one female and four male patients (mean age, 44.4 years) with hyperlipidemia.
In the five study patients, we measured serum lipids in conjunction with serum thyroxine (T4), triiodothyronine (T3) resin uptake, T3, free T4, thyroid-stimulating hormone (TSH), and thyroxine-binding globulin before, during, and after treatment with nicotinic acid.
Serum lipid levels responded appropriately to nicotinic acid treatment. Thyroid function studies done a mean of 1.3 years (range, 0.5 to 3.5) after initiation of nicotinic acid therapy (mean daily dose, 2.6 ± 0.7 g) revealed significant decreases in serum levels of total T4 (21 %), free T4 index (16%), T3 (13 %), and thyroxine-binding globulin (23 %) (P |
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ISSN: | 0025-6196 1942-5546 |
DOI: | 10.4065/70.6.556 |