Selective induction of interleukin‐1 receptor antagonist and interleukin‐8 in human monocytes by normal polyspecific IgG (intravenous immunoglobulin)

We have investigated the effects of intravenous immunoglobulin (IVIg), a therapeutic preparation of normal human polyspecific IgG, on the synthesis and release of cytokines by peripheral blood monocytes. IVIg was found to selectively induce gene transcription and secretion of interleukin‐1 receptor...

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Veröffentlicht in:	European journal of immunology 1995-05, Vol.25 (5), p.1267-1273
Hauptverfasser:	de Souza, Valéria Ruiz, Carreno, Marie‐Paule, Kaveri, Srinivas V., Ledur, Annick, Sadeghi, Hoss, Cavaillon, Jean‐Marc, Kazatchkine, Michel D., Haeffner‐Cavaillon, Nicole
Format:	Artikel
Sprache:	eng
Schlagworte:	Antagonist Cell Communication Cells, Cultured Cytokines - biosynthesis Cytokines - genetics Dose-Response Relationship, Immunologic Gene Expression Regulation - drug effects Humans Immunoglobulin Fab Fragments - pharmacology Immunoglobulin Fc Fragments - pharmacology Immunoglobulins, Intravenous - pharmacology Interleukin 1 Receptor Antagonist Protein Interleukin-8 - biosynthesis Interleukin-8 - genetics Interleukin-8 - secretion Interleukin‐1 receptor antagonist Interleukin‐8 Intravenous immunoglobulins Lipopolysaccharides - pharmacology Monocytes - drug effects Monocytes - metabolism Monocytes - secretion RNA, Messenger - biosynthesis RNA, Messenger - genetics Sialoglycoproteins - biosynthesis Sialoglycoproteins - genetics Sialoglycoproteins - secretion Signal Transduction T-Lymphocytes - immunology
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