Fertility in patients with gestational trophoblastic tumors treated with etoposide
The effect of etoposide containing drug combinations on reproductive performance was studied in women successfully treated for gestational trophoblastic disease between 1977 and 1984. Of the 74 women who wished to get pregnant 57 (77.0%) succeeded in having at least one live birth while five (5.8%)...
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| Veröffentlicht in: | European journal of cancer & clinical oncology 1986-12, Vol.22 (12), p.1479-1482 |
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| container_end_page | 1482 |
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| container_issue | 12 |
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| container_title | European journal of cancer & clinical oncology |
| container_volume | 22 |
| creator | Adewole, I.F. Rustin, G.J.S. Newlands, E.S. Dent, J. Bagshawe, K.D. |
| description | The effect of etoposide containing drug combinations on reproductive performance was studied in women successfully treated for gestational trophoblastic disease between 1977 and 1984. Of the 74 women who wished to get pregnant 57 (77.0%) succeeded in having at least one live birth while five (5.8%) have ongoing pregnancies. Of eight (19.8%) women who have not become pregnant two (2.7%) had previous infertility problems antedating the development of gestational trophoblastic disease. The miscarriage rate was
124
1000
. There was only one case of foetal death and one congenital abnormality (microcephaly possibly associated with cytomegalo-virus infection) among 79 live births and stillbirths. This study indicates that etoposide (VP16-213) as is currently used in this unit for the treatment of gestational trophoblastic tumour is unlikely to have any long-term effect on fertility in most women. |
| doi_str_mv | 10.1016/0277-5379(86)90083-0 |
| format | Article |
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124
1000
. There was only one case of foetal death and one congenital abnormality (microcephaly possibly associated with cytomegalo-virus infection) among 79 live births and stillbirths. This study indicates that etoposide (VP16-213) as is currently used in this unit for the treatment of gestational trophoblastic tumour is unlikely to have any long-term effect on fertility in most women.</description><identifier>ISSN: 0277-5379</identifier><identifier>DOI: 10.1016/0277-5379(86)90083-0</identifier><identifier>PMID: 3036533</identifier><identifier>CODEN: EJCODS</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adult ; Antineoplastic Combined Chemotherapy Protocols - administration & dosage ; Biological and medical sciences ; Drug toxicity and drugs side effects treatment ; Etoposide - administration & dosage ; Etoposide - therapeutic use ; Female ; Fertility - drug effects ; Humans ; Medical sciences ; Pharmacology. Drug treatments ; Pregnancy ; Time Factors ; Toxicity: urogenital system ; Trophoblastic Neoplasms - drug therapy ; Trophoblastic Neoplasms - physiopathology ; Uterine Neoplasms - drug therapy ; Uterine Neoplasms - physiopathology</subject><ispartof>European journal of cancer & clinical oncology, 1986-12, Vol.22 (12), p.1479-1482</ispartof><rights>1986</rights><rights>1987 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-9f3315f083bcc7dffb8ad383ce2554a8b962632a01bf1d0fc715d96df63ff093</citedby><cites>FETCH-LOGICAL-c386t-9f3315f083bcc7dffb8ad383ce2554a8b962632a01bf1d0fc715d96df63ff093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8118067$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3036533$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Adewole, I.F.</creatorcontrib><creatorcontrib>Rustin, G.J.S.</creatorcontrib><creatorcontrib>Newlands, E.S.</creatorcontrib><creatorcontrib>Dent, J.</creatorcontrib><creatorcontrib>Bagshawe, K.D.</creatorcontrib><title>Fertility in patients with gestational trophoblastic tumors treated with etoposide</title><title>European journal of cancer & clinical oncology</title><addtitle>Eur J Cancer Clin Oncol</addtitle><description>The effect of etoposide containing drug combinations on reproductive performance was studied in women successfully treated for gestational trophoblastic disease between 1977 and 1984. Of the 74 women who wished to get pregnant 57 (77.0%) succeeded in having at least one live birth while five (5.8%) have ongoing pregnancies. Of eight (19.8%) women who have not become pregnant two (2.7%) had previous infertility problems antedating the development of gestational trophoblastic disease. The miscarriage rate was
124
1000
. There was only one case of foetal death and one congenital abnormality (microcephaly possibly associated with cytomegalo-virus infection) among 79 live births and stillbirths. This study indicates that etoposide (VP16-213) as is currently used in this unit for the treatment of gestational trophoblastic tumour is unlikely to have any long-term effect on fertility in most women.</description><subject>Adult</subject><subject>Antineoplastic Combined Chemotherapy Protocols - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Etoposide - administration & dosage</subject><subject>Etoposide - therapeutic use</subject><subject>Female</subject><subject>Fertility - drug effects</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Pregnancy</subject><subject>Time Factors</subject><subject>Toxicity: urogenital system</subject><subject>Trophoblastic Neoplasms - drug therapy</subject><subject>Trophoblastic Neoplasms - physiopathology</subject><subject>Uterine Neoplasms - drug therapy</subject><subject>Uterine Neoplasms - physiopathology</subject><issn>0277-5379</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhnNQ_Fj9Bwo9iOihmnS2aXoRZPELFgTxHtJkopFuU5Os4r836y579DTwzjPDy0PICaNXjDJ-TaumKWto2gvBL1tKBZR0hxxs431yGOMHpZWY1rBH9oACrwEOyMs9huR6l34KNxSjSg6HFItvl96LN4wpB35QfZGCH99916uYnC7ScuFDzCGqhGZNY_Kjj87gEdm1qo94vJkT8np_9zp7LOfPD0-z23mpQfBUthaA1TZX7bRujLWdUAYEaKzqeqpE1_KKQ6Uo6ywz1OqG1ablxnKwlrYwIefrt2Pwn8tcVS5c1Nj3akC_jLJpoKqgWoHTNaiDjzGglWNwCxV-JKNyZU-uNMmVJim4_LMnaT473fxfdgs026ONurw_2-xV1Kq3QQ3axS0mGBOUNxm7WWOYVXw5DDLq7FijcQF1ksa7_3v8At6wjx4</recordid><startdate>19861201</startdate><enddate>19861201</enddate><creator>Adewole, I.F.</creator><creator>Rustin, G.J.S.</creator><creator>Newlands, E.S.</creator><creator>Dent, J.</creator><creator>Bagshawe, K.D.</creator><general>Elsevier Ltd</general><general>Pergamon Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19861201</creationdate><title>Fertility in patients with gestational trophoblastic tumors treated with etoposide</title><author>Adewole, I.F. ; Rustin, G.J.S. ; Newlands, E.S. ; Dent, J. ; Bagshawe, K.D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-9f3315f083bcc7dffb8ad383ce2554a8b962632a01bf1d0fc715d96df63ff093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Adult</topic><topic>Antineoplastic Combined Chemotherapy Protocols - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Etoposide - administration & dosage</topic><topic>Etoposide - therapeutic use</topic><topic>Female</topic><topic>Fertility - drug effects</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Pregnancy</topic><topic>Time Factors</topic><topic>Toxicity: urogenital system</topic><topic>Trophoblastic Neoplasms - drug therapy</topic><topic>Trophoblastic Neoplasms - physiopathology</topic><topic>Uterine Neoplasms - drug therapy</topic><topic>Uterine Neoplasms - physiopathology</topic><toplevel>online_resources</toplevel><creatorcontrib>Adewole, I.F.</creatorcontrib><creatorcontrib>Rustin, G.J.S.</creatorcontrib><creatorcontrib>Newlands, E.S.</creatorcontrib><creatorcontrib>Dent, J.</creatorcontrib><creatorcontrib>Bagshawe, K.D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of cancer & clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adewole, I.F.</au><au>Rustin, G.J.S.</au><au>Newlands, E.S.</au><au>Dent, J.</au><au>Bagshawe, K.D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fertility in patients with gestational trophoblastic tumors treated with etoposide</atitle><jtitle>European journal of cancer & clinical oncology</jtitle><addtitle>Eur J Cancer Clin Oncol</addtitle><date>1986-12-01</date><risdate>1986</risdate><volume>22</volume><issue>12</issue><spage>1479</spage><epage>1482</epage><pages>1479-1482</pages><issn>0277-5379</issn><coden>EJCODS</coden><abstract>The effect of etoposide containing drug combinations on reproductive performance was studied in women successfully treated for gestational trophoblastic disease between 1977 and 1984. Of the 74 women who wished to get pregnant 57 (77.0%) succeeded in having at least one live birth while five (5.8%) have ongoing pregnancies. Of eight (19.8%) women who have not become pregnant two (2.7%) had previous infertility problems antedating the development of gestational trophoblastic disease. The miscarriage rate was
124
1000
. There was only one case of foetal death and one congenital abnormality (microcephaly possibly associated with cytomegalo-virus infection) among 79 live births and stillbirths. This study indicates that etoposide (VP16-213) as is currently used in this unit for the treatment of gestational trophoblastic tumour is unlikely to have any long-term effect on fertility in most women.</abstract><cop>Oxford</cop><cop>New York, NY</cop><pub>Elsevier Ltd</pub><pmid>3036533</pmid><doi>10.1016/0277-5379(86)90083-0</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0277-5379 |
| ispartof | European journal of cancer & clinical oncology, 1986-12, Vol.22 (12), p.1479-1482 |
| issn | 0277-5379 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Antineoplastic Combined Chemotherapy Protocols - administration & dosage Biological and medical sciences Drug toxicity and drugs side effects treatment Etoposide - administration & dosage Etoposide - therapeutic use Female Fertility - drug effects Humans Medical sciences Pharmacology. Drug treatments Pregnancy Time Factors Toxicity: urogenital system Trophoblastic Neoplasms - drug therapy Trophoblastic Neoplasms - physiopathology Uterine Neoplasms - drug therapy Uterine Neoplasms - physiopathology |
| title | Fertility in patients with gestational trophoblastic tumors treated with etoposide |
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