A novel electrophilic high affinity irreversible probe for the cannabinoid receptor

In order to explore the structural requirements for cannabinoid activity we have been involved in the design and synthesis of stereochemically defined high affinity probes for the cannabinoid receptor This effort has involved the development of irreversible ligands which will allow us to obtain deta...

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Veröffentlicht in:	Life sciences (1973) 1995, Vol.56 (23), p.1957-1962
Hauptverfasser:	Morse, Kelley L., Fournier, Donna J., Li, Xiuyan, Grzybowska, Jolanta, Makriyannis, Alexandros
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Labels Animals Binding, Competitive cannabinoid receptor covalent ligand Cannabinoids - agonists Cannabinoids - metabolism Cyclohexanols - metabolism Dronabinol - analogs & derivatives Dronabinol - chemistry Dronabinol - metabolism Dronabinol - pharmacology electrophilic affinity label In Vitro Techniques isothiocyanate Ligands Protein Binding Rats Receptors, Cannabinoid Receptors, Drug - chemistry Receptors, Drug - metabolism Synaptosomes - metabolism
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