Synthesis of enantio-manoyl oxides: Modifiers of the activity of adenylatecyclase enzyme

Cyclization of methyl ent-8 α-hydroxylabd-13(16),14-dien-18-oate with m-chloroperbenzoic acid gave methyl (13 S)- ent-16-hydroxy-8 α,13-epoxylabd-14-en-18-oate and its epimer at C-13. Biotransformation of the former (which exhibits antileishmania activity) with Rhizopus nigricans cultures produced t...

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Veröffentlicht in:	Phytochemistry (Oxford) 1995, Vol.38 (2), p.287-293
Hauptverfasser:	García-Granados, Andrés, Liñán, Emilio, Martínez, Antonio, Onorato, M.Esther, Parra, Andrés, Arias, JoséMaría
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae adenylate cyclase Adenylyl Cyclase Inhibitors Adenylyl Cyclases - drug effects Adenylyl Cyclases - metabolism Animals Benzopyrans - chemical synthesis Benzopyrans - pharmacokinetics Benzopyrans - pharmacology Bioconversions. Hemisynthesis Biological and medical sciences biosynthesis Biotechnology Biotransformation chemical reactions Enzyme Activation enzyme activity Fundamental and applied biological sciences. Psychology inhibitors Leishmania donovani - drug effects Magnetic Resonance Spectroscopy metabolites Methods. Procedures. Technologies molecular conformation Molecular Structure oxides Rhizopus - metabolism Rhizopus nigricans Rhizopus stolonifer spectral analysis Stereoisomerism
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