Cytokine elevations in infants with bacterial and aseptic meningitis
We sought to determine whether the detection of cytokines, produced during the inflammatory response, would aid in the diagnosis of meningitis in young infants. We measured cerebrospinal fluid (CSF) and plasma levels of interleukin-6 (IL-6) and tumor necrosis factor (TNF) in 62 infants less than 6 m...
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| Veröffentlicht in: | The Journal of pediatrics 1995-06, Vol.126 (6), p.872-876 |
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| container_title | The Journal of pediatrics |
| container_volume | 126 |
| creator | Dulkerian, Susan J. Kilpatrick, Laurie Costarino, Andrew T. McCawley, Lisa Fein, Joel Corcoran, Linda Zirin, Sharon Harris, Mary Catherine |
| description | We sought to determine whether the detection of cytokines, produced during the inflammatory response, would aid in the diagnosis of meningitis in young infants. We measured cerebrospinal fluid (CSF) and plasma levels of interleukin-6 (IL-6) and tumor necrosis factor (TNF) in 62 infants less than 6 months of age whose condition was evaluated for meningitis. Twenty infants had culture-proved meningitis, 22 had aseptic meningitis, and 20 control infants had no evidence of meningitis. The CSF IL-6 levels were elevated in all 20 infants with bacterial meningitis and in 9 of 22 infants with aseptic meningitis but were undetectable in all control subjects. Furthermore, CSF IL-6 levels were 10 times greater in infants with bacterial versus aseptic meningitis (p |
| doi_str_mv | 10.1016/S0022-3476(95)70199-0 |
| format | Article |
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We measured cerebrospinal fluid (CSF) and plasma levels of interleukin-6 (IL-6) and tumor necrosis factor (TNF) in 62 infants less than 6 months of age whose condition was evaluated for meningitis. Twenty infants had culture-proved meningitis, 22 had aseptic meningitis, and 20 control infants had no evidence of meningitis. The CSF IL-6 levels were elevated in all 20 infants with bacterial meningitis and in 9 of 22 infants with aseptic meningitis but were undetectable in all control subjects. Furthermore, CSF IL-6 levels were 10 times greater in infants with bacterial versus aseptic meningitis (p <0.001). Levels of TNF in CSF were detected in 12 of 20 infants with bacterial meningitis and were undetectable in infants with aseptic meningitis and in control infants (p <0.02). Plasma IL-6 and TNF levels were unreliable for the detection of meningitis in this patient population. We conclude that the presence of IL-6 in the CSF reliably identifies infants with meningitis and that the presence of CSF TNF is a highly specific indicator of bacterial meningeal inflammation. (J PEDIATR 1995;126:872-6)</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/S0022-3476(95)70199-0</identifier><identifier>PMID: 7776086</identifier><identifier>CODEN: JOPDAB</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Bacterial diseases ; Bacterial diseases of the nervous system. Bacterial myositis ; Biological and medical sciences ; Human bacterial diseases ; Humans ; Infant ; Infectious diseases ; Interleukin-6 - blood ; Interleukin-6 - cerebrospinal fluid ; Medical sciences ; Meningitis, Aseptic - cerebrospinal fluid ; Meningitis, Aseptic - diagnosis ; Meningitis, Bacterial - cerebrospinal fluid ; Meningitis, Bacterial - diagnosis ; Tumor Necrosis Factor-alpha - analysis ; Tumor Necrosis Factor-alpha - cerebrospinal fluid</subject><ispartof>The Journal of pediatrics, 1995-06, Vol.126 (6), p.872-876</ispartof><rights>1995 Mosby, Inc.</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-df652713fe0e20ce1d0612d08c858ce1a2fd6bb572fed1bfd372756b93753b853</citedby><cites>FETCH-LOGICAL-c389t-df652713fe0e20ce1d0612d08c858ce1a2fd6bb572fed1bfd372756b93753b853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0022347695701990$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,23909,23910,25118,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3574895$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7776086$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dulkerian, Susan J.</creatorcontrib><creatorcontrib>Kilpatrick, Laurie</creatorcontrib><creatorcontrib>Costarino, Andrew T.</creatorcontrib><creatorcontrib>McCawley, Lisa</creatorcontrib><creatorcontrib>Fein, Joel</creatorcontrib><creatorcontrib>Corcoran, Linda</creatorcontrib><creatorcontrib>Zirin, Sharon</creatorcontrib><creatorcontrib>Harris, Mary Catherine</creatorcontrib><title>Cytokine elevations in infants with bacterial and aseptic meningitis</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>We sought to determine whether the detection of cytokines, produced during the inflammatory response, would aid in the diagnosis of meningitis in young infants. We measured cerebrospinal fluid (CSF) and plasma levels of interleukin-6 (IL-6) and tumor necrosis factor (TNF) in 62 infants less than 6 months of age whose condition was evaluated for meningitis. Twenty infants had culture-proved meningitis, 22 had aseptic meningitis, and 20 control infants had no evidence of meningitis. The CSF IL-6 levels were elevated in all 20 infants with bacterial meningitis and in 9 of 22 infants with aseptic meningitis but were undetectable in all control subjects. Furthermore, CSF IL-6 levels were 10 times greater in infants with bacterial versus aseptic meningitis (p <0.001). Levels of TNF in CSF were detected in 12 of 20 infants with bacterial meningitis and were undetectable in infants with aseptic meningitis and in control infants (p <0.02). Plasma IL-6 and TNF levels were unreliable for the detection of meningitis in this patient population. We conclude that the presence of IL-6 in the CSF reliably identifies infants with meningitis and that the presence of CSF TNF is a highly specific indicator of bacterial meningeal inflammation. (J PEDIATR 1995;126:872-6)</description><subject>Bacterial diseases</subject><subject>Bacterial diseases of the nervous system. Bacterial myositis</subject><subject>Biological and medical sciences</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infant</subject><subject>Infectious diseases</subject><subject>Interleukin-6 - blood</subject><subject>Interleukin-6 - cerebrospinal fluid</subject><subject>Medical sciences</subject><subject>Meningitis, Aseptic - cerebrospinal fluid</subject><subject>Meningitis, Aseptic - diagnosis</subject><subject>Meningitis, Bacterial - cerebrospinal fluid</subject><subject>Meningitis, Bacterial - diagnosis</subject><subject>Tumor Necrosis Factor-alpha - analysis</subject><subject>Tumor Necrosis Factor-alpha - cerebrospinal fluid</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1rGzEQQEVJSZy0PyGwhxCawyaj1UpanUJwkzZg6KHtWWilUatmrXUkOcH_vuvY-BoYGIZ588Ej5JzCNQUqbn4CNE3NWim-KH4lgSpVwwcyo6BkLTrGjsjsgJyQ05z_AYBqAY7JsZRSQCdm5Ot8U8anELHCAV9MCWPMVYhTeBNLrl5D-Vv1xhZMwQyVia4yGVcl2GqJMcQ_oYT8iXz0Zsj4eZ_PyO-H-1_z7_Xix7fH-d2itqxTpXZe8EZS5hGwAYvUgaCNg852vJtK03gn-p7LxqOjvXdMNpKLXjHJWd9xdkYud3tXaXxeYy56GbLFYTARx3XWUjLaKtlOIN-BNo05J_R6lcLSpI2moLf29Js9vVWjFddv9jRMc-f7A-t-ie4wtdc19S_2fZOtGXwy0YZ8wBiXbae2f97uMJxkvARMOtuA0aILCW3RbgzvPPIf8DWL2w</recordid><startdate>19950601</startdate><enddate>19950601</enddate><creator>Dulkerian, Susan J.</creator><creator>Kilpatrick, Laurie</creator><creator>Costarino, Andrew T.</creator><creator>McCawley, Lisa</creator><creator>Fein, Joel</creator><creator>Corcoran, Linda</creator><creator>Zirin, Sharon</creator><creator>Harris, Mary Catherine</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19950601</creationdate><title>Cytokine elevations in infants with bacterial and aseptic meningitis</title><author>Dulkerian, Susan J. ; Kilpatrick, Laurie ; Costarino, Andrew T. ; McCawley, Lisa ; Fein, Joel ; Corcoran, Linda ; Zirin, Sharon ; Harris, Mary Catherine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-df652713fe0e20ce1d0612d08c858ce1a2fd6bb572fed1bfd372756b93753b853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Bacterial diseases</topic><topic>Bacterial diseases of the nervous system. Bacterial myositis</topic><topic>Biological and medical sciences</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infant</topic><topic>Infectious diseases</topic><topic>Interleukin-6 - blood</topic><topic>Interleukin-6 - cerebrospinal fluid</topic><topic>Medical sciences</topic><topic>Meningitis, Aseptic - cerebrospinal fluid</topic><topic>Meningitis, Aseptic - diagnosis</topic><topic>Meningitis, Bacterial - cerebrospinal fluid</topic><topic>Meningitis, Bacterial - diagnosis</topic><topic>Tumor Necrosis Factor-alpha - analysis</topic><topic>Tumor Necrosis Factor-alpha - cerebrospinal fluid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dulkerian, Susan J.</creatorcontrib><creatorcontrib>Kilpatrick, Laurie</creatorcontrib><creatorcontrib>Costarino, Andrew T.</creatorcontrib><creatorcontrib>McCawley, Lisa</creatorcontrib><creatorcontrib>Fein, Joel</creatorcontrib><creatorcontrib>Corcoran, Linda</creatorcontrib><creatorcontrib>Zirin, Sharon</creatorcontrib><creatorcontrib>Harris, Mary Catherine</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dulkerian, Susan J.</au><au>Kilpatrick, Laurie</au><au>Costarino, Andrew T.</au><au>McCawley, Lisa</au><au>Fein, Joel</au><au>Corcoran, Linda</au><au>Zirin, Sharon</au><au>Harris, Mary Catherine</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytokine elevations in infants with bacterial and aseptic meningitis</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>1995-06-01</date><risdate>1995</risdate><volume>126</volume><issue>6</issue><spage>872</spage><epage>876</epage><pages>872-876</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><coden>JOPDAB</coden><abstract>We sought to determine whether the detection of cytokines, produced during the inflammatory response, would aid in the diagnosis of meningitis in young infants. We measured cerebrospinal fluid (CSF) and plasma levels of interleukin-6 (IL-6) and tumor necrosis factor (TNF) in 62 infants less than 6 months of age whose condition was evaluated for meningitis. Twenty infants had culture-proved meningitis, 22 had aseptic meningitis, and 20 control infants had no evidence of meningitis. The CSF IL-6 levels were elevated in all 20 infants with bacterial meningitis and in 9 of 22 infants with aseptic meningitis but were undetectable in all control subjects. Furthermore, CSF IL-6 levels were 10 times greater in infants with bacterial versus aseptic meningitis (p <0.001). Levels of TNF in CSF were detected in 12 of 20 infants with bacterial meningitis and were undetectable in infants with aseptic meningitis and in control infants (p <0.02). Plasma IL-6 and TNF levels were unreliable for the detection of meningitis in this patient population. We conclude that the presence of IL-6 in the CSF reliably identifies infants with meningitis and that the presence of CSF TNF is a highly specific indicator of bacterial meningeal inflammation. (J PEDIATR 1995;126:872-6)</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>7776086</pmid><doi>10.1016/S0022-3476(95)70199-0</doi><tpages>5</tpages></addata></record> |
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| subjects | Bacterial diseases Bacterial diseases of the nervous system. Bacterial myositis Biological and medical sciences Human bacterial diseases Humans Infant Infectious diseases Interleukin-6 - blood Interleukin-6 - cerebrospinal fluid Medical sciences Meningitis, Aseptic - cerebrospinal fluid Meningitis, Aseptic - diagnosis Meningitis, Bacterial - cerebrospinal fluid Meningitis, Bacterial - diagnosis Tumor Necrosis Factor-alpha - analysis Tumor Necrosis Factor-alpha - cerebrospinal fluid |
| title | Cytokine elevations in infants with bacterial and aseptic meningitis |
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