Low doses of pulsed ultrasound and chromosomal abnormalities in male mouse germ cells
Male mice were exposed to pulsed ultrasound (intensity
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| Veröffentlicht in: | Human reproduction (Oxford) 1986-11, Vol.1 (7), p.427-431 |
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| container_title | Human reproduction (Oxford) |
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| creator | Moutschen, J. Demoulin, A. Gilot-Delhalle, J. Richelle, M. Lambotte, R. |
| description | Male mice were exposed to pulsed ultrasound (intensity |
| doi_str_mv | 10.1093/oxfordjournals.humrep.a136446 |
| format | Article |
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After 30 h, 11, 12 or 13 days, the testes were cytologically and histologically examined (using squash preparations, air-drying and sections). The resulting damage was studied at diakinesis—metaphase I and II, spermatogonial metaphase and anaphase. The investigation by air-drying did not show any significant increase in chromosome damage, 30 h, 11, 12 and 13 days after treatment (spermatogonial and spermatocytic metaphases). There was, however, a significant increase of the frequency of aneuploid cells detected at metaphase II. Investigations by squash techniques or sections did not reveal adverse effects on the spindles at spermatogonial and spermatocytic anaphases. We suggest that the reduction of fertility previously observed in our clinic could be explained by an increase of aneuploidy if germ cells are exposed to ultrasound during diakinesis of the first meiotic division.</description><identifier>ISSN: 0268-1161</identifier><identifier>EISSN: 1460-2350</identifier><identifier>DOI: 10.1093/oxfordjournals.humrep.a136446</identifier><identifier>PMID: 3571437</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Anaphase ; Animals ; Chromosome Aberrations - etiology ; Chromosome Disorders ; Male ; Metaphase ; Mice ; Spermatogonia - pathology ; Testis - cytology ; Ultrasonics - adverse effects</subject><ispartof>Human reproduction (Oxford), 1986-11, Vol.1 (7), p.427-431</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-21b6a95749dc71a4e8349cfc08fa6c87e107554e454ad2f1bb4e1e0250ed98bd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3571437$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moutschen, J.</creatorcontrib><creatorcontrib>Demoulin, A.</creatorcontrib><creatorcontrib>Gilot-Delhalle, J.</creatorcontrib><creatorcontrib>Richelle, M.</creatorcontrib><creatorcontrib>Lambotte, R.</creatorcontrib><title>Low doses of pulsed ultrasound and chromosomal abnormalities in male mouse germ cells</title><title>Human reproduction (Oxford)</title><addtitle>Hum Reprod</addtitle><description>Male mice were exposed to pulsed ultrasound (intensity <1 mW, frequency 3.5 MHz) for 30 min or to sham treatment. After 30 h, 11, 12 or 13 days, the testes were cytologically and histologically examined (using squash preparations, air-drying and sections). The resulting damage was studied at diakinesis—metaphase I and II, spermatogonial metaphase and anaphase. The investigation by air-drying did not show any significant increase in chromosome damage, 30 h, 11, 12 and 13 days after treatment (spermatogonial and spermatocytic metaphases). There was, however, a significant increase of the frequency of aneuploid cells detected at metaphase II. Investigations by squash techniques or sections did not reveal adverse effects on the spindles at spermatogonial and spermatocytic anaphases. We suggest that the reduction of fertility previously observed in our clinic could be explained by an increase of aneuploidy if germ cells are exposed to ultrasound during diakinesis of the first meiotic division.</description><subject>Anaphase</subject><subject>Animals</subject><subject>Chromosome Aberrations - etiology</subject><subject>Chromosome Disorders</subject><subject>Male</subject><subject>Metaphase</subject><subject>Mice</subject><subject>Spermatogonia - pathology</subject><subject>Testis - cytology</subject><subject>Ultrasonics - adverse effects</subject><issn>0268-1161</issn><issn>1460-2350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAYhIMouq7-BCEXvXVNms8ePPi9yoIXBfES0uatVttmTVrUf29kF8GTh5CBmUmGB6FDSmaUFOzYf9Y-uFc_ht62cfYydgGWM0uZ5FxuoAnlkmQ5E2QTTUgudUappDtoN8ZXQpLUchttM6EoZ2qCHhb-AzsfIWJf4-XYRnB4bIdgox97h2061UvwnY--sy22Ze9DEs3QpErT46QBd36MgJ8hdLiCto17aKtO42B_fU_Rw9Xl_fk8W9xd35yfLrKK6WLIclpKWwjFC1cpajloxouqroiuray0AkqUEBy44NblNS1LDhRILgi4QpeOTdHR6t1l8O8jxMF0TfxZYHtIk4xSjHKt8n-DCRpTMhcpeLIKVsHHGKA2y9B0NnwZSswPf_OXv1nxN2v-qX-w_mgsO3C_7TXw5Gcrv4kDfP7aNrwZqZgSZv74ZC6ulCqezm6NZt8f1Jnb</recordid><startdate>19861101</startdate><enddate>19861101</enddate><creator>Moutschen, J.</creator><creator>Demoulin, A.</creator><creator>Gilot-Delhalle, J.</creator><creator>Richelle, M.</creator><creator>Lambotte, R.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19861101</creationdate><title>Low doses of pulsed ultrasound and chromosomal abnormalities in male mouse germ cells</title><author>Moutschen, J. ; Demoulin, A. ; Gilot-Delhalle, J. ; Richelle, M. ; Lambotte, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-21b6a95749dc71a4e8349cfc08fa6c87e107554e454ad2f1bb4e1e0250ed98bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Anaphase</topic><topic>Animals</topic><topic>Chromosome Aberrations - etiology</topic><topic>Chromosome Disorders</topic><topic>Male</topic><topic>Metaphase</topic><topic>Mice</topic><topic>Spermatogonia - pathology</topic><topic>Testis - cytology</topic><topic>Ultrasonics - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moutschen, J.</creatorcontrib><creatorcontrib>Demoulin, A.</creatorcontrib><creatorcontrib>Gilot-Delhalle, J.</creatorcontrib><creatorcontrib>Richelle, M.</creatorcontrib><creatorcontrib>Lambotte, R.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Human reproduction (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moutschen, J.</au><au>Demoulin, A.</au><au>Gilot-Delhalle, J.</au><au>Richelle, M.</au><au>Lambotte, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low doses of pulsed ultrasound and chromosomal abnormalities in male mouse germ cells</atitle><jtitle>Human reproduction (Oxford)</jtitle><addtitle>Hum Reprod</addtitle><date>1986-11-01</date><risdate>1986</risdate><volume>1</volume><issue>7</issue><spage>427</spage><epage>431</epage><pages>427-431</pages><issn>0268-1161</issn><eissn>1460-2350</eissn><abstract>Male mice were exposed to pulsed ultrasound (intensity <1 mW, frequency 3.5 MHz) for 30 min or to sham treatment. After 30 h, 11, 12 or 13 days, the testes were cytologically and histologically examined (using squash preparations, air-drying and sections). The resulting damage was studied at diakinesis—metaphase I and II, spermatogonial metaphase and anaphase. The investigation by air-drying did not show any significant increase in chromosome damage, 30 h, 11, 12 and 13 days after treatment (spermatogonial and spermatocytic metaphases). There was, however, a significant increase of the frequency of aneuploid cells detected at metaphase II. Investigations by squash techniques or sections did not reveal adverse effects on the spindles at spermatogonial and spermatocytic anaphases. We suggest that the reduction of fertility previously observed in our clinic could be explained by an increase of aneuploidy if germ cells are exposed to ultrasound during diakinesis of the first meiotic division.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>3571437</pmid><doi>10.1093/oxfordjournals.humrep.a136446</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0268-1161 |
| ispartof | Human reproduction (Oxford), 1986-11, Vol.1 (7), p.427-431 |
| issn | 0268-1161 1460-2350 |
| language | eng |
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| source | MEDLINE; Oxford University Press Archive |
| subjects | Anaphase Animals Chromosome Aberrations - etiology Chromosome Disorders Male Metaphase Mice Spermatogonia - pathology Testis - cytology Ultrasonics - adverse effects |
| title | Low doses of pulsed ultrasound and chromosomal abnormalities in male mouse germ cells |
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