Stimulation of rat striatal tyrosine hydroxylase activity following intranigral administration of σ receptor ligands
The effects of σ ligands on turning behavior and striatal tyrosine hydroxylase activity were determined following microinjection of two chemically dissimilar σ ligands into the rat substantia nigra. Striatal tyrosine hydroxylase activty was monitored by measuring the amount of 3,4-dihydroxyphenylala...
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| Veröffentlicht in: | European journal of pharmacology 1995-02, Vol.275 (1), p.1-7 |
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| creator | Weiser, Sheri D. Patrick, Saundra L. Mascarella, S.Wayne Downing-Park, Jeannette Bai, Xu Carroll, F.Ivy Walker, J.Michael Patrick, Robert L. |
| description | The effects of σ ligands on turning behavior and striatal tyrosine hydroxylase activity were determined following microinjection of two chemically dissimilar σ ligands into the rat substantia nigra. Striatal tyrosine hydroxylase activty was monitored by measuring the amount of 3,4-dihydroxyphenylalanine (DOPA) formed following inhibition of DOPA decarboxylase activity with
m-hydroxybenzylhydrazine (NSD-1015). The σ ligands, 1,3-di-
o-tolylguanidine (DTG) and (−)-deoxy-
N-benzylnormetazocine, produced a significant increase both in contralateral turning and in tyrosine hydroxylase activity. The DTG-induced increase in tyrosine hydroxylase activity was not antagonized by intranigral injection of the NMDA receptor antagonist, 3-(2-carboxypiperazine-4-yl)-propyl-1-phosphonic acid (CPP). CPP alone produced significant contralateral turning that was not accompanied by an increase in striatal tyrosine hydroxylase activity, indicating that turning per se is not sufficient to activate striatal tyrosine hydroxylase. The DTG-induced increase in tyrosine hydroxylase activity was antagonized by general anesthetics such as halothane and chloral hydrate. These results indicate that occupancy of σ receptors in the substantia nigra is associated with an activation of dopamine formation in dopaminergic terminals in the striatum and support the concept that σ activity in the substantia nigra produces an activation of dopamine-mediated responses in the striatum. |
| doi_str_mv | 10.1016/0014-2999(94)00718-M |
| format | Article |
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m-hydroxybenzylhydrazine (NSD-1015). The σ ligands, 1,3-di-
o-tolylguanidine (DTG) and (−)-deoxy-
N-benzylnormetazocine, produced a significant increase both in contralateral turning and in tyrosine hydroxylase activity. The DTG-induced increase in tyrosine hydroxylase activity was not antagonized by intranigral injection of the NMDA receptor antagonist, 3-(2-carboxypiperazine-4-yl)-propyl-1-phosphonic acid (CPP). CPP alone produced significant contralateral turning that was not accompanied by an increase in striatal tyrosine hydroxylase activity, indicating that turning per se is not sufficient to activate striatal tyrosine hydroxylase. The DTG-induced increase in tyrosine hydroxylase activity was antagonized by general anesthetics such as halothane and chloral hydrate. These results indicate that occupancy of σ receptors in the substantia nigra is associated with an activation of dopamine formation in dopaminergic terminals in the striatum and support the concept that σ activity in the substantia nigra produces an activation of dopamine-mediated responses in the striatum.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/0014-2999(94)00718-M</identifier><identifier>PMID: 7774655</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Anticonvulsants - pharmacology ; Aromatic Amino Acid Decarboxylase Inhibitors ; Behavior, Animal - drug effects ; Biological and medical sciences ; Central nervous system ; Central neurotransmission. Neuromudulation. Pathways and receptors ; Chromatography, High Pressure Liquid ; Corpus Striatum - drug effects ; Corpus Striatum - enzymology ; Cyclazocine - analogs & derivatives ; Cyclazocine - pharmacology ; Dihydroxyphenylalanine - metabolism ; Dopamine ; DTG (1,3-di- o-tolylguanidine) ; Fundamental and applied biological sciences. Psychology ; Guanidines - administration & dosage ; Guanidines - pharmacology ; Hydrazines - pharmacology ; Male ; Microinjections ; Piperazines - pharmacology ; Rats ; Rats, Sprague-Dawley ; Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors ; Receptors, sigma - drug effects ; Receptors, sigma - metabolism ; Substantia Nigra - drug effects ; Substantia Nigra - metabolism ; Turning ; Tyrosine 3-Monooxygenase - metabolism ; Tyrosine hydroxylase ; Vertebrates: nervous system and sense organs ; σ Receptor ligand</subject><ispartof>European journal of pharmacology, 1995-02, Vol.275 (1), p.1-7</ispartof><rights>1995</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-83b68469124e2ee1cbaae662d889ddabfd1abba9a3a59c4af9ef70677c6bbca63</citedby><cites>FETCH-LOGICAL-c417t-83b68469124e2ee1cbaae662d889ddabfd1abba9a3a59c4af9ef70677c6bbca63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0014-2999(94)00718-M$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3554,27933,27934,46004</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3426769$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7774655$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Weiser, Sheri D.</creatorcontrib><creatorcontrib>Patrick, Saundra L.</creatorcontrib><creatorcontrib>Mascarella, S.Wayne</creatorcontrib><creatorcontrib>Downing-Park, Jeannette</creatorcontrib><creatorcontrib>Bai, Xu</creatorcontrib><creatorcontrib>Carroll, F.Ivy</creatorcontrib><creatorcontrib>Walker, J.Michael</creatorcontrib><creatorcontrib>Patrick, Robert L.</creatorcontrib><title>Stimulation of rat striatal tyrosine hydroxylase activity following intranigral administration of σ receptor ligands</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>The effects of σ ligands on turning behavior and striatal tyrosine hydroxylase activity were determined following microinjection of two chemically dissimilar σ ligands into the rat substantia nigra. Striatal tyrosine hydroxylase activty was monitored by measuring the amount of 3,4-dihydroxyphenylalanine (DOPA) formed following inhibition of DOPA decarboxylase activity with
m-hydroxybenzylhydrazine (NSD-1015). The σ ligands, 1,3-di-
o-tolylguanidine (DTG) and (−)-deoxy-
N-benzylnormetazocine, produced a significant increase both in contralateral turning and in tyrosine hydroxylase activity. The DTG-induced increase in tyrosine hydroxylase activity was not antagonized by intranigral injection of the NMDA receptor antagonist, 3-(2-carboxypiperazine-4-yl)-propyl-1-phosphonic acid (CPP). CPP alone produced significant contralateral turning that was not accompanied by an increase in striatal tyrosine hydroxylase activity, indicating that turning per se is not sufficient to activate striatal tyrosine hydroxylase. The DTG-induced increase in tyrosine hydroxylase activity was antagonized by general anesthetics such as halothane and chloral hydrate. These results indicate that occupancy of σ receptors in the substantia nigra is associated with an activation of dopamine formation in dopaminergic terminals in the striatum and support the concept that σ activity in the substantia nigra produces an activation of dopamine-mediated responses in the striatum.</description><subject>Animals</subject><subject>Anticonvulsants - pharmacology</subject><subject>Aromatic Amino Acid Decarboxylase Inhibitors</subject><subject>Behavior, Animal - drug effects</subject><subject>Biological and medical sciences</subject><subject>Central nervous system</subject><subject>Central neurotransmission. Neuromudulation. Pathways and receptors</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Corpus Striatum - drug effects</subject><subject>Corpus Striatum - enzymology</subject><subject>Cyclazocine - analogs & derivatives</subject><subject>Cyclazocine - pharmacology</subject><subject>Dihydroxyphenylalanine - metabolism</subject><subject>Dopamine</subject><subject>DTG (1,3-di- o-tolylguanidine)</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Guanidines - administration & dosage</subject><subject>Guanidines - pharmacology</subject><subject>Hydrazines - pharmacology</subject><subject>Male</subject><subject>Microinjections</subject><subject>Piperazines - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors</subject><subject>Receptors, sigma - drug effects</subject><subject>Receptors, sigma - metabolism</subject><subject>Substantia Nigra - drug effects</subject><subject>Substantia Nigra - metabolism</subject><subject>Turning</subject><subject>Tyrosine 3-Monooxygenase - metabolism</subject><subject>Tyrosine hydroxylase</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>σ Receptor ligand</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2OFCEURonRjD2jb6AJC2PGRSlUUVBsJjET_5KZuFDX5BZQLYaCFqjRWvuAvpK03emlrgi55365OR9CTyh5SQnlrwihrGmllJeSvSBE0KG5vYc2dBCyqb_2PtqckIfoPOdvhJBetv0ZOhNCMN73G7R8Km5ePBQXA44TTlBwLslBAY_LmmJ2weKvq0nx5-ohWwy6uDtXVjxF7-MPF7bYhZIguG2qO2BmF1yNOEX-_oWT1XZXYsLebSGY_Ag9mMBn-_j4XqAvb998vn7f3Hx89-H69U2jGRWlGbqRD4xL2jLbWkv1CGA5b80wSGNgnAyFcQQJHfRSM5iknQThQmg-jhp4d4GeH3J3KX5fbC5qdllb7yHYuGQlREcZkfK_IOVDP3SSVZAdQF3V5GQntUtuhrQqStS-FrV3rvbOlWTqby3qtq49PeYv42zNaenYQ50_O84ha_BT1aldPmEda7ng-zOvDpit0u6cTSprZ4O2xlXFRZno_n3HH93hrjg</recordid><startdate>19950224</startdate><enddate>19950224</enddate><creator>Weiser, Sheri D.</creator><creator>Patrick, Saundra L.</creator><creator>Mascarella, S.Wayne</creator><creator>Downing-Park, Jeannette</creator><creator>Bai, Xu</creator><creator>Carroll, F.Ivy</creator><creator>Walker, J.Michael</creator><creator>Patrick, Robert L.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19950224</creationdate><title>Stimulation of rat striatal tyrosine hydroxylase activity following intranigral administration of σ receptor ligands</title><author>Weiser, Sheri D. ; Patrick, Saundra L. ; Mascarella, S.Wayne ; Downing-Park, Jeannette ; Bai, Xu ; Carroll, F.Ivy ; Walker, J.Michael ; Patrick, Robert L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-83b68469124e2ee1cbaae662d889ddabfd1abba9a3a59c4af9ef70677c6bbca63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Anticonvulsants - pharmacology</topic><topic>Aromatic Amino Acid Decarboxylase Inhibitors</topic><topic>Behavior, Animal - drug effects</topic><topic>Biological and medical sciences</topic><topic>Central nervous system</topic><topic>Central neurotransmission. Neuromudulation. Pathways and receptors</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Corpus Striatum - drug effects</topic><topic>Corpus Striatum - enzymology</topic><topic>Cyclazocine - analogs & derivatives</topic><topic>Cyclazocine - pharmacology</topic><topic>Dihydroxyphenylalanine - metabolism</topic><topic>Dopamine</topic><topic>DTG (1,3-di- o-tolylguanidine)</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Guanidines - administration & dosage</topic><topic>Guanidines - pharmacology</topic><topic>Hydrazines - pharmacology</topic><topic>Male</topic><topic>Microinjections</topic><topic>Piperazines - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors</topic><topic>Receptors, sigma - drug effects</topic><topic>Receptors, sigma - metabolism</topic><topic>Substantia Nigra - drug effects</topic><topic>Substantia Nigra - metabolism</topic><topic>Turning</topic><topic>Tyrosine 3-Monooxygenase - metabolism</topic><topic>Tyrosine hydroxylase</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>σ Receptor ligand</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Weiser, Sheri D.</creatorcontrib><creatorcontrib>Patrick, Saundra L.</creatorcontrib><creatorcontrib>Mascarella, S.Wayne</creatorcontrib><creatorcontrib>Downing-Park, Jeannette</creatorcontrib><creatorcontrib>Bai, Xu</creatorcontrib><creatorcontrib>Carroll, F.Ivy</creatorcontrib><creatorcontrib>Walker, J.Michael</creatorcontrib><creatorcontrib>Patrick, Robert L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Weiser, Sheri D.</au><au>Patrick, Saundra L.</au><au>Mascarella, S.Wayne</au><au>Downing-Park, Jeannette</au><au>Bai, Xu</au><au>Carroll, F.Ivy</au><au>Walker, J.Michael</au><au>Patrick, Robert L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stimulation of rat striatal tyrosine hydroxylase activity following intranigral administration of σ receptor ligands</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1995-02-24</date><risdate>1995</risdate><volume>275</volume><issue>1</issue><spage>1</spage><epage>7</epage><pages>1-7</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>The effects of σ ligands on turning behavior and striatal tyrosine hydroxylase activity were determined following microinjection of two chemically dissimilar σ ligands into the rat substantia nigra. Striatal tyrosine hydroxylase activty was monitored by measuring the amount of 3,4-dihydroxyphenylalanine (DOPA) formed following inhibition of DOPA decarboxylase activity with
m-hydroxybenzylhydrazine (NSD-1015). The σ ligands, 1,3-di-
o-tolylguanidine (DTG) and (−)-deoxy-
N-benzylnormetazocine, produced a significant increase both in contralateral turning and in tyrosine hydroxylase activity. The DTG-induced increase in tyrosine hydroxylase activity was not antagonized by intranigral injection of the NMDA receptor antagonist, 3-(2-carboxypiperazine-4-yl)-propyl-1-phosphonic acid (CPP). CPP alone produced significant contralateral turning that was not accompanied by an increase in striatal tyrosine hydroxylase activity, indicating that turning per se is not sufficient to activate striatal tyrosine hydroxylase. The DTG-induced increase in tyrosine hydroxylase activity was antagonized by general anesthetics such as halothane and chloral hydrate. These results indicate that occupancy of σ receptors in the substantia nigra is associated with an activation of dopamine formation in dopaminergic terminals in the striatum and support the concept that σ activity in the substantia nigra produces an activation of dopamine-mediated responses in the striatum.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>7774655</pmid><doi>10.1016/0014-2999(94)00718-M</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Anticonvulsants - pharmacology Aromatic Amino Acid Decarboxylase Inhibitors Behavior, Animal - drug effects Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Chromatography, High Pressure Liquid Corpus Striatum - drug effects Corpus Striatum - enzymology Cyclazocine - analogs & derivatives Cyclazocine - pharmacology Dihydroxyphenylalanine - metabolism Dopamine DTG (1,3-di- o-tolylguanidine) Fundamental and applied biological sciences. Psychology Guanidines - administration & dosage Guanidines - pharmacology Hydrazines - pharmacology Male Microinjections Piperazines - pharmacology Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, sigma - drug effects Receptors, sigma - metabolism Substantia Nigra - drug effects Substantia Nigra - metabolism Turning Tyrosine 3-Monooxygenase - metabolism Tyrosine hydroxylase Vertebrates: nervous system and sense organs σ Receptor ligand |
| title | Stimulation of rat striatal tyrosine hydroxylase activity following intranigral administration of σ receptor ligands |
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