Impact on Empiric Treatment of Group A Streptococcal Pharyngitis Using an Optical Immunoassay

The potential impact of using a rapid diagnostic test (Strep A OIA) on detection and treatment of group A β-hemolytic streptococcal (GABHS) pharyngitis in a large-volume pediatric and adolescent clinic was examined. Of 519 swabs processed for both culture and the OIA test, 114 were culture-positive...

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Veröffentlicht in:	Clinical pediatrics 1995-03, Vol.34 (3), p.122-127
Hauptverfasser:	Harris, Richard, Paine, Donald, Wittler, Robert, Bruhn, Frederic
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Sprache:	eng
Schlagworte:	Adolescent Anti-Bacterial Agents - therapeutic use Bacteriological Techniques Child Child, Preschool Costs and Cost Analysis Culture Media Humans Immunoassay - methods Pharyngitis - drug therapy Pharyngitis - economics Pharyngitis - microbiology Sensitivity and Specificity Streptococcal Infections Streptococcus pyogenes - isolation & purification
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container_title	Clinical pediatrics
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creator	Harris, Richard Paine, Donald Wittler, Robert Bruhn, Frederic
description	The potential impact of using a rapid diagnostic test (Strep A OIA) on detection and treatment of group A β-hemolytic streptococcal (GABHS) pharyngitis in a large-volume pediatric and adolescent clinic was examined. Of 519 swabs processed for both culture and the OIA test, 114 were culture-positive for GABHS compared with 133 positive by the OIA test, for an agreement of 94%. OIA test sensitivity compared with culture was 96%, and specificity was 94%. Forty-seven percent of all study patients were empirically placed on antibiotics. In-clinic OIA testing could have reduced inappropriate therapy and been a cost-effective alternative to culture.
doi_str_mv	10.1177/000992289503400301
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subjects	Adolescent Anti-Bacterial Agents - therapeutic use Bacteriological Techniques Child Child, Preschool Costs and Cost Analysis Culture Media Humans Immunoassay - methods Pharyngitis - drug therapy Pharyngitis - economics Pharyngitis - microbiology Sensitivity and Specificity Streptococcal Infections Streptococcus pyogenes - isolation & purification
title	Impact on Empiric Treatment of Group A Streptococcal Pharyngitis Using an Optical Immunoassay
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