Thrombin-Receptor Occupancy Initiates a Transient Increase in CAMP Levels in Mitogenically Responsive Hamster (NIL) Fibroblasts

Previous studies from our laboratory have shown that thrombin mitogenesis requires both high-affinity receptor occupancy and enzymic activity. Combined addition of DIP-inactivated-thrombin, which retains the ability to bind to thrombin receptors, and enzymically active gamma-thrombin generates a com...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 1986, Vol.485 (1), p.249-263
Hauptverfasser:	GORDON, ERIC A, II, JOHN W. FENTON, CARNEY, DARRELL H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Division Cell Line Cricetinae Cyclic AMP - analogs & derivatives Cyclic AMP - metabolism Kinetics Receptors, Cell Surface - physiology Receptors, Mitogen - physiology Receptors, Thrombin Thrombin - antagonists & inhibitors Thrombin - physiology
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